دورية أكاديمية
أعرض في EDS

PEERNaija-a mobile health platform incentivizing medication adherence among youth living with HIV in Nigeria: study protocol for a randomized controlled trial.

التفاصيل البيبلوغرافية
العنوان: PEERNaija-a mobile health platform incentivizing medication adherence among youth living with HIV in Nigeria: study protocol for a randomized controlled trial.
المؤلفون: Pierce LJ; Vanderbilt Institute for Global Health, Vanderbilt University Medical Center, Nashville, TN, USA., Were MC; Vanderbilt Institute for Global Health, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA., Amaral S; Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA, USA., Aliyu MH; Vanderbilt Institute for Global Health, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Health Policy, Vanderbilt University Medical Center, Nashville, TN, USA., Ezechi O; Nigerian Institute of Medical Research, Lagos, Nigeria., David A; Nigerian Institute of Medical Research, Lagos, Nigeria., Idigbe I; Nigerian Institute of Medical Research, Lagos, Nigeria., Musa AZ; Nigerian Institute of Medical Research, Lagos, Nigeria., Okonkwo P; APIN Public Health Initiatives (APIN), Abuja, Nigeria., Dowshen N; Craig-Dalsimer Division of Adolescent Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Ahonkhai AA; Vanderbilt Institute for Global Health, Vanderbilt University Medical Center, Nashville, TN, USA. aimalohi.a.ahonkhai@vumc.org.; Department of Medicine, Infectious Diseases, Vanderbilt University Medical Center, Nashville, TN, USA. aimalohi.a.ahonkhai@vumc.org.; Massachusetts General Hospital, Division of Infectious Diseases, Boston, MA, USA. aimalohi.a.ahonkhai@vumc.org.; Harvard University Center for AIDS Research, Boston, MA, USA. aimalohi.a.ahonkhai@vumc.org.
المصدر: Pilot and feasibility studies [Pilot Feasibility Stud] 2023 Oct 27; Vol. 9 (1), pp. 179. Date of Electronic Publication: 2023 Oct 27.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101676536 Publication Model: Electronic Cited Medium: Print ISSN: 2055-5784 (Print) Linking ISSN: 20555784 NLM ISO Abbreviation: Pilot Feasibility Stud Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: London : BioMed Central, [2015]-
مستخلص: Background: Poor medication adherence is a major barrier to HIV control among youth living with HIV (Y-PLWH). The PEERNaija application (app) is an adapted smartphone app grounded in social cognitive and contigency management theories and designed to harness peer-based social incentives and conditional financial incentives to promote medication adherence. The app delivers a multifaceted medication adherence intervention including (1) peer-based social incentives, (2) financial incentives, (3) virtual peer social support, and (4) early clinic-based outreach for non-adherent Y-PLWH. A pilot trial of the app will be conducted in Nigeria, Africa's most populous country with the 4th largest HIV epidemic, and home to 10% of the world's four million Y-PLWH.
Methods: In this randomized controlled trial, we will compare implementation outcomes (feasibility, acceptability, appropriateness measured via validated scales, enrollment and application installation rates, feedback surveys and focus group discussions with participants, and back-end application data), and preliminary efficacy (in improving medication adherence and viral suppression) of the PEERNaija app at 6 months. Participants in Arm 1 (PEERNaija) will receive daily medication reminders, peer-based social incentives, and virtual peer social support. Participants in Arm 2 (PEERNaija +) will additionally receive a conditional financial incentive based on their adherence performance. Eligibility for Y-PLWH includes (1) being aged 14-29 years, (2) being on ART, (3) owning a smartphone, (4) being willing to download an app, and (5) being able to read simple text in English.
Discussion: This study will serve as the basis for a larger intervention trial evaluating the PEERNaija app (and the integration of mHealth, incentive, and peer-support-based strategies) to improve HIV outcomes in a critically important region of the world for Y-PLWH.
Trial Registration: ClinicalTrials.gov. NCT04930198. First submitted date: May 25, 2021. Study start: August 1, 2021, https://clinicaltrials.gov/ .
Protocol Version: January 21, 2022.
(© 2023. The Author(s).)
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معلومات مُعتمدة: R21 TW011327 United States TW FIC NIH HHS; R25 MH080665 United States MH NIMH NIH HHS; NIH/FIC R21 TW011327 United States TW FIC NIH HHS; R25MH08065 United States MH NIMH NIH HHS
فهرسة مساهمة: Keywords: Adherence; HIV; Mobile health; Young adults
سلسلة جزيئية: ClinicalTrials.gov NCT04930198
تواريخ الأحداث: Date Created: 20231027 Latest Revision: 20231128
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC10605971
DOI: 10.1186/s40814-023-01404-0
PMID: 37891681
قاعدة البيانات: MEDLINE
الوصف
تدمد:2055-5784
DOI:10.1186/s40814-023-01404-0