دورية أكاديمية
أعرض في EDS

Neurolysin Knockout Mice in a Diet-Induced Obesity Model.

التفاصيل البيبلوغرافية
العنوان: Neurolysin Knockout Mice in a Diet-Induced Obesity Model.
المؤلفون: Caprioli B; Pharmacology Department, Biomedical Sciences Institute (ICB), São Paulo 05508-000, SP, Brazil., Eichler RAS; Pharmacology Department, Biomedical Sciences Institute (ICB), São Paulo 05508-000, SP, Brazil., Silva RNO; Pharmacology Department, Biomedical Sciences Institute (ICB), São Paulo 05508-000, SP, Brazil., Martucci LF; Pharmacology Department, Biomedical Sciences Institute (ICB), São Paulo 05508-000, SP, Brazil., Reckziegel P; Department of Clinical and Toxicological Analysis, Faculty of Pharmaceutical Sciences (FCF), University of São Paulo (USP), São Paulo 05508-000, SP, Brazil., Ferro ES; Pharmacology Department, Biomedical Sciences Institute (ICB), São Paulo 05508-000, SP, Brazil.
المصدر: International journal of molecular sciences [Int J Mol Sci] 2023 Oct 14; Vol. 24 (20). Date of Electronic Publication: 2023 Oct 14.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, [2000-
مواضيع طبية MeSH: Obesity*/genetics , Obesity*/metabolism , Diet*/adverse effects, Rats ; Mice ; Animals ; Male ; Female ; Mice, Knockout ; Metalloendopeptidases/genetics
مستخلص: Neurolysin oligopeptidase (E.C.3.4.24.16; Nln), a member of the zinc metallopeptidase M3 family, was first identified in rat brain synaptic membranes hydrolyzing neurotensin at the Pro-Tyr peptide bond. The previous development of C57BL6/N mice with suppression of Nln gene expression (Nln -/- ), demonstrated the biological relevance of this oligopeptidase for insulin signaling and glucose uptake. Here, several metabolic parameters were investigated in Nln -/- and wild-type C57BL6/N animals (WT; n = 5-8), male and female, fed either a standard (SD) or a hypercaloric diet (HD), for seven weeks. Higher food intake and body mass gain was observed for Nln -/- animals fed HD, compared to both male and female WT control animals fed HD. Leptin gene expression was higher in Nln -/- male and female animals fed HD, compared to WT controls. Both WT and Nln -/- females fed HD showed similar gene expression increase of dipeptidyl peptidase 4 (DPP4), a peptidase related to glucagon-like peptide-1 (GLP-1) metabolism. The present data suggest that Nln participates in the physiological mechanisms related to diet-induced obesity. Further studies will be necessary to better understand the molecular mechanism responsible for the higher body mass gain observed in Nln -/- animals fed HD.
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معلومات مُعتمدة: 2016/04000-3 São Paulo Research Foundation
فهرسة مساهمة: Keywords: adipose tissue; diet-induced obesity; glucagon-like peptide-1; intracellular peptides; leptin; neurolysin; neurotensin; obesity
المشرفين على المادة: EC 3.4.24.16 (neurolysin)
EC 3.4.24.- (Metalloendopeptidases)
تواريخ الأحداث: Date Created: 20231028 Date Completed: 20231030 Latest Revision: 20231030
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC10607720
DOI: 10.3390/ijms242015190
PMID: 37894869
قاعدة البيانات: MEDLINE
الوصف
تدمد:1422-0067
DOI:10.3390/ijms242015190