دورية أكاديمية
أعرض في EDS

Cultured Mesenchymal Cells from Nasal Turbinate as a Cellular Model of the Neurodevelopmental Component of Schizophrenia Etiology.

التفاصيل البيبلوغرافية
العنوان: Cultured Mesenchymal Cells from Nasal Turbinate as a Cellular Model of the Neurodevelopmental Component of Schizophrenia Etiology.
المؤلفون: Tung VSK; Department of Cell Biology, State University of New York at Downstate, Brooklyn, NY 11203, USA., Mathews F; Department of Otolaryngology, State University of New York at Downstate, Brooklyn, NY 11203, USA., Boruk M; Department of Otolaryngology, State University of New York at Downstate, Brooklyn, NY 11203, USA., Suppa G; Department of Cell Biology, State University of New York at Downstate, Brooklyn, NY 11203, USA., Foronjy R; Department of Cell Biology, State University of New York at Downstate, Brooklyn, NY 11203, USA., Pato MT; Department of Psychiatry, Rutgers University, Piscataway, NJ 08854, USA., Pato CN; Department of Psychiatry, Rutgers University, Piscataway, NJ 08854, USA., Knowles JA; Human Genetics Institute of New Jersey, Rutgers University, Piscataway, NJ 08854, USA., Evgrafov OV; Department of Cell Biology, State University of New York at Downstate, Brooklyn, NY 11203, USA.; Human Genetics Institute of New Jersey, Rutgers University, Piscataway, NJ 08854, USA.
المصدر: International journal of molecular sciences [Int J Mol Sci] 2023 Oct 19; Vol. 24 (20). Date of Electronic Publication: 2023 Oct 19.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, [2000-
مواضيع طبية MeSH: Schizophrenia*/genetics , Schizophrenia*/metabolism , Neural Stem Cells*/metabolism, Humans ; Turbinates/pathology ; Cells, Cultured ; Neurons/metabolism
مستخلص: The study of neurodevelopmental molecular mechanisms in schizophrenia requires the development of adequate biological models such as patient-derived cells and their derivatives. We previously utilized cell lines with neural progenitor properties (CNON) derived from the superior or middle turbinates of patients with schizophrenia and control groups to study schizophrenia-specific gene expression. In this study, we analyzed single-cell RNA seq data from two CNON cell lines (one derived from an individual with schizophrenia (SCZ) and the other from a control group) and two biopsy samples from the middle turbinate (MT) (also from an individual with SCZ and a control). We compared our data with previously published data regarding the olfactory neuroepithelium and demonstrated that CNON originated from a single cell type present both in middle turbinate and the olfactory neuroepithelium and expressed in multiple markers of mesenchymal cells. To define the relatedness of CNON to the developing human brain, we also compared CNON datasets with scRNA-seq data derived from an embryonic brain and found that the expression profile of the CNON closely matched the expression profile one of the cell types in the embryonic brain. Finally, we evaluated the differences between SCZ and control samples to assess the utility and potential benefits of using CNON single-cell RNA seq to study the etiology of schizophrenia.
التعليقات: Update of: bioRxiv. 2023 Mar 29;:. (PMID: 37034711)
References: Trends Neurosci. 2022 Jan;45(1):8-26. (PMID: 34876311)
Toxicol Pathol. 2007 Jun;35(4):495-516. (PMID: 17562483)
Am J Pathol. 2010 Aug;177(2):598-607. (PMID: 20595636)
AJNR Am J Neuroradiol. 2013 Dec;34(12):2233-40. (PMID: 23493891)
Nat Neurosci. 2020 Mar;23(3):323-326. (PMID: 32066986)
Stem Cells. 2009 Sep;27(9):2196-208. (PMID: 19544421)
Schizophr Bull. 2017 Oct 21;43(6):1190-1196. (PMID: 28981842)
Dev Growth Differ. 2016 Jun;58(5):469-80. (PMID: 27273235)
Transl Psychiatry. 2016 Oct 11;6(10):e915. (PMID: 27727244)
Stem Cell Res Ther. 2021 Jul 13;12(1):402. (PMID: 34256823)
Biomol Ther (Seoul). 2020 Jan 1;28(1):34-44. (PMID: 31649208)
Stem Cells. 2011 Dec;29(12):1915-22. (PMID: 22009633)
Stem Cell Rev Rep. 2012 Sep;8(3):658-71. (PMID: 22170630)
Stem Cells Dev. 2010 Jun;19(6):819-30. (PMID: 20132052)
Cells. 2021 Dec 09;10(12):. (PMID: 34943975)
Nucleic Acids Res. 2002 Jan 1;30(1):207-10. (PMID: 11752295)
Arch Gen Psychiatry. 2001 Sep;58(9):829-35. (PMID: 11545665)
Pediatr Res. 2005 May;57(5 Pt 2):104R-109R. (PMID: 15817497)
Br J Psychiatry. 2015 Jul;207(1):37-45. (PMID: 25858177)
Stem Cells Dev. 2010 Jun;19(6):853-66. (PMID: 19905894)
Front Neurosci. 2022 Mar 29;16:844410. (PMID: 35422684)
BMC Biol. 2015 Nov 23;13:99. (PMID: 26596888)
Lung India. 2016 Mar-Apr;33(2):174-8. (PMID: 27051106)
Curr Opin Psychiatry. 2017 May;30(3):176-183. (PMID: 28333692)
Cell. 2021 Jun 24;184(13):3573-3587.e29. (PMID: 34062119)
Nat Neurosci. 2021 Apr;24(4):584-594. (PMID: 33723434)
Biomed Pharmacother. 2019 Jun;114:108765. (PMID: 30921703)
Cytotherapy. 2006;8(4):315-7. (PMID: 16923606)
J Neurosci Res. 2000 Dec 1;62(5):737-49. (PMID: 11104513)
Biol Psychiatry. 2015 Sep 15;78(6):e29-34. (PMID: 25708228)
J Mol Neurosci. 1992;3(3):137-46. (PMID: 1320921)
Cells. 2012 Dec;1(4):874. (PMID: 23626909)
Cell Transplant. 2011;20(1):5-14. (PMID: 21396235)
J Vis Exp. 2011 Aug 22;(54):. (PMID: 21876529)
Rhinology. 2022 Feb 1;60(1):47-55. (PMID: 34647543)
Exp Neurol. 2004 Apr;186(2):112-23. (PMID: 15026250)
Hum Gene Ther. 2010 Sep;21(9):1045-56. (PMID: 20565251)
Cold Spring Harb Perspect Biol. 2012 Jul 01;4(7):a008094. (PMID: 22621768)
Int Forum Allergy Rhinol. 2013 Feb;3(2):133-8. (PMID: 23192985)
PLoS One. 2011;6(9):e25450. (PMID: 21980461)
Psychiatr Genet. 2011 Oct;21(5):217-28. (PMID: 21451437)
Glia. 2013 Mar;61(3):368-82. (PMID: 23281012)
Cells. 2022 Feb 15;11(4):. (PMID: 35203328)
Biol Psychiatry. 2020 Aug 1;88(3):236-247. (PMID: 32143829)
Cell Stem Cell. 2010 Dec 3;7(6):744-58. (PMID: 21112568)
Stem Cells. 2012 Nov;30(11):2361-5. (PMID: 22961669)
Gene. 2009 Mar 15;433(1-2):1-7. (PMID: 19135507)
معلومات مُعتمدة: R01 MH086874 United States MH NIMH NIH HHS; Grant MH086874 United States MH NIMH NIH HHS
فهرسة مساهمة: Keywords: mesenchymal cells; middle turbinate; neurodevelopment; scRNA-seq; schizophrenia
تواريخ الأحداث: Date Created: 20231028 Date Completed: 20231030 Latest Revision: 20240210
رمز التحديث: 20240210
مُعرف محوري في PubMed: PMC10607243
DOI: 10.3390/ijms242015339
PMID: 37895019
قاعدة البيانات: MEDLINE
الوصف
تدمد:1422-0067
DOI:10.3390/ijms242015339