دورية أكاديمية
أعرض في EDS

Analysis of Epidemiological Factors and SNP rs3804100 of TLR2 for COVID-19 in a Cohort of Professionals Who Worked in the First Pandemic Wave in Belém-PA, Brazil.

التفاصيل البيبلوغرافية
العنوان: Analysis of Epidemiological Factors and SNP rs3804100 of TLR2 for COVID-19 in a Cohort of Professionals Who Worked in the First Pandemic Wave in Belém-PA, Brazil.
المؤلفون: Silva MJA; Master Program in Epidemiology and Health Surveillance (PPGEVS), Evandro Chagas Institute (IEC), Ananindeua 67030-000, PA, Brazil., Silva CS; Master and PhD Program in Parasitic Biology in the Amazon (PPGBPA), University of State of Pará (UEPA), Belém 66087-670, PA, Brazil., Marinho RL; Evandro Chagas Institute (IEC), Ananindeua 67030-000, PA, Brazil., Cabral JG; Evandro Chagas Institute (IEC), Ananindeua 67030-000, PA, Brazil., Gurrão EPDC; Evandro Chagas Institute (IEC), Ananindeua 67030-000, PA, Brazil., Dos Santos PAS; Master and PhD Program in Parasitic Biology in the Amazon (PPGBPA), University of State of Pará (UEPA), Belém 66087-670, PA, Brazil., Casseb SMM; Evandro Chagas Institute (IEC), Ananindeua 67030-000, PA, Brazil., Lima KVB; Evandro Chagas Institute (IEC), Ananindeua 67030-000, PA, Brazil., Lima LNGC; Evandro Chagas Institute (IEC), Ananindeua 67030-000, PA, Brazil.
المصدر: Genes [Genes (Basel)] 2023 Oct 05; Vol. 14 (10). Date of Electronic Publication: 2023 Oct 05.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101551097 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4425 (Electronic) Linking ISSN: 20734425 NLM ISO Abbreviation: Genes (Basel) Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel : MDPI
مواضيع طبية MeSH: Polymorphism, Single Nucleotide* , COVID-19*/epidemiology , COVID-19*/genetics, Humans ; Toll-Like Receptor 2/genetics ; Genetic Predisposition to Disease ; Case-Control Studies ; Pandemics ; Brazil/epidemiology ; SARS-CoV-2/genetics
مستخلص: COVID-19 is an infectious disease caused by coronavirus 2 of the severe acute syndrome (SARS-CoV-2). Single nucleotide polymorphisms (SNPs) in genes, such as TLR2 , responsible for an effective human immune response, can change the course of infection. The objective of this article was to verify associations between epidemiological factors and TLR2 SNP rs3804100 (Thymine [T] > Cytosine [C]) in professionals from Health Institutions (HI) who worked during the first pandemic wave and COVID-19. A case-control study was conducted with Belém-PA HI workers (Northern Brazil), divided into symptomatology groups (Asymptomatic-AS; n = 91; and Symptomatic-SI; n = 123); and severity groups classified by Chest Computerized Tomography data (symptomatic with pulmonary involvement-SCP; n = 35; symptomatic without pulmonary involvement-SSP; n = 8). Genotyping was performed by Sanger sequencing, and Statistical Analysis was conducted through the SPSS program. Bioinformatics servers predicted the biological functions of the TLR2 SNP. There were associations between the presence of comorbidities and poor prognosis of COVID-19 (especially between symptomatology and severity of COVID-19 and overweight and obesity) and between the sickness in family members and kinship (related to blood relatives). The homozygous recessive (C/C) genotype was not found, and the frequency of the mutant allele (C) was less than 10% in the cohort. No significant associations were found for this SNP in this cohort. The presence of SNP was indicated to be benign and causes a decrease in the stability of the TLR2 protein. These data can help the scientific community and medicine find new forms of COVID-19 containment.
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فهرسة مساهمة: Keywords: COVID-19; TLR2; epidemiology; single nucleotide polymorphism
المشرفين على المادة: 0 (Toll-Like Receptor 2)
0 (TLR2 protein, human)
تواريخ الأحداث: Date Created: 20231028 Date Completed: 20231030 Latest Revision: 20231106
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC10606513
DOI: 10.3390/genes14101907
PMID: 37895256
قاعدة البيانات: MEDLINE
الوصف
تدمد:2073-4425
DOI:10.3390/genes14101907