دورية أكاديمية

The Safety of Bacteriophages in Treatment of Diseases Caused by Multidrug-Resistant Bacteria.

التفاصيل البيبلوغرافية
العنوان: The Safety of Bacteriophages in Treatment of Diseases Caused by Multidrug-Resistant Bacteria.
المؤلفون: Chung KM; Division of Microbiology and Molecular Genetics, Institute of Biological Sciences, Faculty of Sciences, University of Malaya, Kuala Lumpur 50603, Malaysia., Nang SC; Department of Microbiology, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia., Tang SS; Division of Microbiology and Molecular Genetics, Institute of Biological Sciences, Faculty of Sciences, University of Malaya, Kuala Lumpur 50603, Malaysia.; Centre for Research in Biotechnology for Agriculture, University of Malaya, Kuala Lumpur 50603, Malaysia.
المصدر: Pharmaceuticals (Basel, Switzerland) [Pharmaceuticals (Basel)] 2023 Sep 24; Vol. 16 (10). Date of Electronic Publication: 2023 Sep 24.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101238453 Publication Model: Electronic Cited Medium: Print ISSN: 1424-8247 (Print) Linking ISSN: 14248247 NLM ISO Abbreviation: Pharmaceuticals (Basel) Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, c2004-
مستخلص: Given the urgency due to the rapid emergence of multidrug-resistant (MDR) bacteria, bacteriophages (phages), which are viruses that specifically target and kill bacteria, are rising as a potential alternative to antibiotics. In recent years, researchers have begun to elucidate the safety aspects of phage therapy with the aim of ensuring safe and effective clinical applications. While phage therapy has generally been demonstrated to be safe and tolerable among animals and humans, the current research on phage safety monitoring lacks sufficient and consistent data. This emphasizes the critical need for a standardized phage safety assessment to ensure a more reliable evaluation of its safety profile. Therefore, this review aims to bridge the knowledge gap concerning phage safety for treating MDR bacterial infections by covering various aspects involving phage applications, including phage preparation, administration, and the implications for human health and the environment.
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معلومات مُعتمدة: FP023-2019A & IIRG002A-2021IISS Ministry of Higher Education
فهرسة مساهمة: Keywords: animal studies; antibiotic-resistant bacteria; clinical trials; endotoxin; human health; phage safety; phage-resistant bacteria
تواريخ الأحداث: Date Created: 20231028 Latest Revision: 20231030
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC10610463
DOI: 10.3390/ph16101347
PMID: 37895818
قاعدة البيانات: MEDLINE
الوصف
تدمد:1424-8247
DOI:10.3390/ph16101347