دورية أكاديمية
أعرض في EDS

Long-term risk of carotid stenosis and cerebrovascular disease after radiation therapy for head and neck cancer.

التفاصيل البيبلوغرافية
العنوان: Long-term risk of carotid stenosis and cerebrovascular disease after radiation therapy for head and neck cancer.
المؤلفون: Carpenter DJ; Department of Radiation Oncology, Duke Cancer Institute, Durham, North Carolina, USA., Patel P; Department of Radiation Oncology, Duke Cancer Institute, Durham, North Carolina, USA., Niedzwiecki D; Department of Biostatistics & Bioinformatics, Duke University Medical Center, Durham, North Carolina, USA.; Duke Cancer Institute Biostatistics, Duke University Medical Center, Durham, North Carolina, USA., Dillon M; Department of Biostatistics & Bioinformatics, Duke University Medical Center, Durham, North Carolina, USA.; Duke Cancer Institute Biostatistics, Duke University Medical Center, Durham, North Carolina, USA., Diaz AK; Department of Radiation Oncology, Duke Cancer Institute, Durham, North Carolina, USA., Kumar A; Department of Radiation Oncology, Duke Cancer Institute, Durham, North Carolina, USA., Mowery YM; Department of Radiation Oncology, Duke Cancer Institute, Durham, North Carolina, USA.; Department of Head and Neck Surgery and Communication Sciences, Duke University Medical Center, Durham, North Carolina, USA., Crowell KA; Department of Biostatistics & Bioinformatics, Duke University Medical Center, Durham, North Carolina, USA.; Duke Cancer Institute Biostatistics, Duke University Medical Center, Durham, North Carolina, USA., D'Anna R; Department of Biostatistics & Bioinformatics, Duke University Medical Center, Durham, North Carolina, USA., Wu Q; Department of Radiation Oncology, Duke Cancer Institute, Durham, North Carolina, USA., Rodrigues A; Department of Radiation Oncology, Duke Cancer Institute, Durham, North Carolina, USA., Wisdom AJ; Department of Radiation Oncology, Dana-Farber/Brigham and Women's Cancer Center, Harvard Medical School, Boston, Massachusetts, USA., Dorth JA; Department of Radiation Oncology, Case Western Reserve University, Cleveland, Ohio, USA., Patel PR; Department of Radiation Oncology, Winship Cancer Institute of Emory University, Atlanta, Georgia, USA., Shortell CK; Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA., Brizel DM; Department of Radiation Oncology, Duke Cancer Institute, Durham, North Carolina, USA.; Department of Head and Neck Surgery and Communication Sciences, Duke University Medical Center, Durham, North Carolina, USA.; Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA.
المصدر: Cancer [Cancer] 2023 Oct 28. Date of Electronic Publication: 2023 Oct 28.
Publication Model: Ahead of Print
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Wiley Country of Publication: United States NLM ID: 0374236 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-0142 (Electronic) Linking ISSN: 0008543X NLM ISO Abbreviation: Cancer Subsets: MEDLINE
أسماء مطبوعة: Publication: <2005- >: Hoboken, NJ : Wiley
Original Publication: New York [etc.] Published for the American Cancer Society by J. Wiley [etc.]
مستخلص: Background: Recipients of radiation therapy (RT) for head and neck cancer (HNC) are at significantly increased risk for carotid artery stenosis (CAS) and cerebrovascular disease (CVD). We sought to determine (1) cumulative incidences of CAS and CVD among HNC survivors after RT and (2) whether CAS is associated with a RT dose response effect.
Methods: This single-institution retrospective cohort study examined patients with nonmetastatic HNC who completed (chemo)RT from January 2000 through October 2020 and subsequently received carotid imaging surveillance ≤2 years following RT completion and, in the absence of CAS, every 3 years thereafter. Exclusion criteria included history of known CAS/CVD. Asymptomatic CAS was defined as ≥50% reduction of luminal diameter, symptomatic CAS as stroke or transient ischemic attack, and composite CAS as asymptomatic or symptomatic CAS.
Results: Of 628 patients undergoing curative intent RT for HNC, median follow-up was 4.8 years (interquartile range, 2.6-8.3), with 97 patients followed ≥10 years. Median age was 61 years and 69% of patients received concurrent chemotherapy and 28% were treated postoperatively. Actuarial 10-year incidences of asymptomatic, symptomatic, and composite CAS were 29.6% (95% CI, 23.9-35.5), 10.1% (95% CI, 7.0-13.9), and 27.2% (95% CI, 22.5-32.1), respectively. Multivariable Cox models significant association between asymptomatic CAS and absolute carotid artery volume receiving ≥10 Gy (per mL: hazard ratio, 1.09; 95% CI, 1.02-1.16).
Conclusions: HNC survivors are at high risk for post-RT CAS. A dose response effect was observed for asymptomatic CAS at doses as low as 10 Gy.
Plain Language Summary: Recipients of radiation therapy for head and neck cancer are at significantly increased risk for carotid artery stenosis and cerebrovascular disease. However, carotid artery screening is not routinely performed among head and neck survivors following radiation therapy. In this single-institution retrospective cohort study, patients with head and neck cancer were initially screened for carotid artery stenosis ≤2 years following radiation therapy completion, then every 3 years thereafter. The 10-year actuarial incidence of carotid artery stenosis was >25% and stroke/transient ischemic attack >10%. Multivariable analysis demonstrated significant associations between asymptomatic carotid artery stenosis and artery volumes receiving ≥10 Gy.
(© 2023 American Cancer Society.)
References: Heart disease and stroke statistics-2022 update: a report from the American Heart Association. Circulation. Published online 2022. Accessed October 19, 2023. https://www.ahajournals.org/doi/abs/10.1161/CIR.0000000000001052.
Naylor R, Rantner B, Ancetti S, et al. European Society for Vascular Surgery (ESVS) 2023 Clinical Practice Guidelines on the management of atherosclerotic carotid and vertebral artery disease. Eur J Vasc Endovasc Surg. 2022;65(1):7-111. doi:10.1016/j.ejvs.2022.04.011.
J Davies K, Thapar A, Kasivisvanathan V, Shalhoub J, Davies H. Review of trans-atlantic cardiovascular best medical therapy guidelines-recommendations for asymptomatic carotid atherosclerosis. Curr Vasc Pharmacol. 2013;11(4):514-523. doi:10.2174/1570161111311040015.
Inzitari D, Eliasziw M, Gates P, et al. The causes and risk of stroke in patients with asymptomatic internal-carotid-artery stenosis. N Engl J Med. 2000;342(23):1693-1701. doi:10.1056/nejm200006083422302.
Piegza M, Więckiewicz G, Wierzba D, Piegza J. Cognitive functions in patients after carotid artery revascularization-a narrative review. Brain Sci. 2021;11(10):1307. doi:10.3390/brainsci11101307.
Lattanzi S, Carbonari L, Pagliariccio G, et al. Neurocognitive functioning and cerebrovascular reactivity after carotid endarterectomy. Neurology. 2018;90(4):e307-e315. doi:10.1212/wnl.0000000000004862.
US Preventive Services Task Force, Krist AH, Davidson KW, et al. Screening for asymptomatic carotid artery stenosis: US Preventive Services Task Force Recommendation Statement. JAMA. 2021;325(5):476-481.
de Weerd M, Greving JP, de Jong AWF, Buskens E, Bots ML. Prevalence of asymptomatic carotid artery stenosis according to age and sex: systematic review and metaregression analysis. Stroke. 2009;40(4):1105-1113. doi:10.1161/strokeaha.108.532218.
AbuRahma AF, Avgerinos ED, Chang RW, et al. Society for Vascular Surgery clinical practice guidelines for management of extracranial cerebrovascular disease. J Vasc Surg. 2022;75(1S):4S-22S. doi:10.1016/j.jvs.2021.04.073.
Caudell JJ, Gillison ML, Maghami E, et al. NCCN Guidelines® Insights: head and neck cancers, version 1.2022: featured updates to the NCCN Guidelines. J Natl Compr Cancer Netw. 2022;20(3):224-234. doi:10.6004/jnccn.2022.0016.
Haddy N, Diallo S, El-Fayech C, et al. Cardiac diseases following childhood cancer treatment: cohort study. Circulation. 2016;133(1):31-38. doi:10.1161/circulationaha.115.016686.
Van Der Pal HJ, Van Dalen EC, Van Delden E, et al. High risk of symptomatic cardiac events in childhood cancer survivors. J Clin Oncol. 2012;30(13):1429-1437. doi:10.1200/jco.2010.33.4730.
Bhakta N, Liu Q, Ness KK, et al. The cumulative burden of surviving childhood cancer: an initial report from the St Jude Lifetime Cohort Study (SJLIFE). Lancet. 2017;390(10112):2569-2582. doi:10.1016/s0140-6736(17)31610-0.
Darby SC, Ewertz M, McGale P, et al. Risk of ischemic heart disease in women after radiotherapy for breast cancer. N Engl J Med. 2013;368(11):987-998. doi:10.1056/nejmoa1209825.
van Aken ESM, van der Laan HP, Bijl HP, et al. Risk of ischaemic cerebrovascular events in head and neck cancer patients is associated with carotid artery radiation dose. Radiother Oncol. 2021;157:182-187. doi:10.1016/j.radonc.2021.01.026.
Lin PY, Cheng PC, Hsu WL, Hsieh CH, Shueng PW, Liao LJ. Risk of CVD following radiotherapy for head and neck cancer: an updated systematic review and meta-analysis. Front Oncol. 2022;12:820808. doi:10.3389/fonc.2022.820808.
Dorth JA, Patel PR, Broadwater G, Brizel DM. Incidence and risk factors of significant carotid artery stenosis in asymptomatic survivors of head and neck cancer after radiotherapy. Head Neck. 2014;36(2):215-219. doi:10.1002/hed.23280.
Carpenter DJ, Mowery YM, Broadwater G, et al. The risk of carotid stenosis in head and neck cancer patients after radiation therapy. Oral Oncol. 2018;80(5):9-15. doi:10.1016/j.ijrobp.2017.12.226.
Lloyd-Jones DM, Wilson PWF, Larson MG, et al. Framingham risk score and prediction of lifetime risk for coronary heart disease. Am J Cardiol. 2004;94(1):20-24. doi:10.1016/j.amjcard.2004.03.023.
Grant EG, Benson CB, Moneta GL, et al. Carotid artery stenosis: Gray-Scale and Doppler US diagnosis-Society of Radiologists in Ultrasound Consensus Conference. Radiology. 2003;229(2):340-346. doi:10.1148/radiol.2292030516.
Hulthe J, Wikstrand J, Emanuelsson H, Wiklund O, de Feyter PJ, Wendelhag I. Atherosclerotic changes in the carotid artery bulb as measured by B-mode ultrasound are associated with the extent of coronary atherosclerosis. Stroke. 1997;28(6):1189-1194. doi:10.1161/01.str.28.6.1189.
de Weerd M, Greving JP, Hedblad B, et al. Prevalence of asymptomatic carotid artery stenosis in the general population: an individual participant data meta-analysis. Stroke. 2010;41(6):1294-1297. doi:10.1161/strokeaha.110.581058.
de Weerd M, Greving JP, Hedblad B, et al. Prediction of asymptomatic carotid artery stenosis in the general population: identification of high-risk groups. Stroke. 2014;45(8):2366-2371. doi:10.1161/strokeaha.114.005145.
Lee JY, Kim YA, Kim HS, et al. Radiotherapy can increase the risk of ischemic cerebrovascular disease in head and neck cancer patients: a Korean population-based cohort study. Radiother Oncol. 2020;142:85-91. doi:10.1016/j.radonc.2019.09.025.
He QS, Wang ZP, Li ZJ, et al. Increased risk of cerebrovascular mortality in head and neck cancer survivors aged ≥ 65 years treated with definitive radiotherapy: a population-based cohort study. Radiat Oncol. 2021;16(1):185. doi:10.1186/s13014-021-01913-3.
Arthurs E, Hanna TP, Zaza K, Peng Y, Hall SF. Stroke after radiation therapy for head and neck cancer: what is the risk? Int J Radiat Oncol Biol Phys. 2016;96(3):589-596. doi:10.1016/j.ijrobp.2016.07.007.
Smith GL, Smith BD, Buchholz TA, et al. Cerebrovascular disease risk in older head and neck cancer patients after radiotherapy. J Clin Oncol. 2008;26(31):5119-5125. doi:10.1200/jco.2008.16.6546.
Sun L, Brody R, Candelieri D, et al. Association between up-front surgery and risk of stroke in US veterans with oropharyngeal carcinoma. JAMA Otolaryngol Head Neck Surg. 2022;148(8):740-747. doi:10.1001/jamaoto.2022.1327.
Nichols AC, Theurer J, Prisman E, et al. Randomized trial of radiotherapy versus transoral robotic surgery for oropharyngeal squamous cell carcinoma: long-term results of the ORATOR Trial. J Clin Oncol. 2022;40(8):866-875. doi:10.1200/jco.21.01961.
Natesan D, Cramer CK, Oyekunle T, Niedzwiecki D, Brizel DM, Mowery YM. Ipsilateral versus bilateral neck radiation therapy for tonsillar squamous cell carcinoma. Int J Radiat Oncol Biol Phys. 2020;108(3):e803-e804. doi:10.1016/j.ijrobp.2020.07.292.
Mehanna H, Rischin D, Wong SJ, et al. De-escalation after DE-ESCALATE and RTOG 1016: A Head and Neck Cancer InterGroup Framework for Future De-Escalation Studies. J Clin Oncol. 2020;38(22):2552-2557. doi:10.1200/jco.20.00056.
فهرسة مساهمة: Keywords: Carotid stenosis; head and neck neoplasms; survivorship
تواريخ الأحداث: Date Created: 20231028 Latest Revision: 20231106
رمز التحديث: 20231215
DOI: 10.1002/cncr.35089
PMID: 37897711
قاعدة البيانات: MEDLINE
الوصف
تدمد:1097-0142
DOI:10.1002/cncr.35089