دورية أكاديمية
The Yin Yang of Complement and Cancer.
| العنوان: | The Yin Yang of Complement and Cancer. |
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| المؤلفون: | Meri S; Department of Bacteriology and Immunology and Translational Immunology Research Program, University and University Hospital of Helsinki, Helsinki, Finland., Magrini E; IRCCS-Humanitas Research Hospital, Milan, Italy., Mantovani A; IRCCS-Humanitas Research Hospital, Milan, Italy.; Department of Biomedical Sciences, Humanitas University, Milan, Italy.; The William Harvey Research Institute, Queen Mary University of London, London, United Kingdom., Garlanda C; IRCCS-Humanitas Research Hospital, Milan, Italy.; Department of Biomedical Sciences, Humanitas University, Milan, Italy. |
| المصدر: | Cancer immunology research [Cancer Immunol Res] 2023 Dec 01; Vol. 11 (12), pp. 1578-1588. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 101614637 Publication Model: Print Cited Medium: Internet ISSN: 2326-6074 (Electronic) Linking ISSN: 23266066 NLM ISO Abbreviation: Cancer Immunol Res Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Philadelphia, PA : American Association for Cancer Research, [2013]- |
| مواضيع طبية MeSH: | Yin-Yang* , Neoplasms*, Humans ; Complement System Proteins ; Complement Activation ; Inflammation ; Tumor Microenvironment |
| مستخلص: | Cancer-related inflammation is a crucial component of the tumor microenvironment (TME). Complement activation occurs in cancer and supports the development of an inflammatory microenvironment. Complement has traditionally been considered a mechanism of immune resistance against cancer, and its activation is known to contribute to the cytolytic effects of antibody-based immunotherapeutic treatments. However, several studies have recently revealed that complement activation may exert protumoral functions by sustaining cancer-related inflammation and immunosuppression through different molecular mechanisms, targeting both the TME and cancer cells. These new discoveries have revealed that complement manipulation can be considered a new strategy for cancer therapies. Here we summarize our current understanding of the mechanisms by which the different elements of the complement system exert antitumor or protumor functions, both in preclinical studies and in human tumorigenesis. Complement components can serve as disease biomarkers for cancer stratification and prognosis and be exploited for tumor treatment. (©2023 American Association for Cancer Research.) |
| معلومات مُعتمدة: | AIRC IG-21714 Associazione Italiana per la Ricerca sul Cancro (AIRC); Finnish Cancer Foundation; Sigrid Jusélius Foundation; RF-2013-02355470 Ministero della Salute (Italy Ministry of Health); 20174T7NXL Ministero dell'Istruzione, dell'Università e della Ricerca (MIUR) |
| المشرفين على المادة: | 9007-36-7 (Complement System Proteins) |
| تواريخ الأحداث: | Date Created: 20231030 Date Completed: 20231204 Latest Revision: 20240313 |
| رمز التحديث: | 20240314 |
| DOI: | 10.1158/2326-6066.CIR-23-0399 |
| PMID: | 37902610 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2326-6074 |
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| DOI: | 10.1158/2326-6066.CIR-23-0399 |