دورية أكاديمية
Associations of ITPA gene polymorphisms with outcomes among chronic hepatitis C patients treated with Peg-interferon/ribavirin: A 5-year follow-up study.
العنوان: | Associations of ITPA gene polymorphisms with outcomes among chronic hepatitis C patients treated with Peg-interferon/ribavirin: A 5-year follow-up study. |
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المؤلفون: | Liu Z; Department of Cardiovascular Medicine, The Third Affiliated Hospital of Changchun University of Chinese Medicine, Changchun, China., Wang Y; Department of Cardiovascular Medicine, The Third Affiliated Hospital of Changchun University of Chinese Medicine, Changchun, China., Li H; Department of Cardiovascular Medicine, The Third Affiliated Hospital of Changchun University of Chinese Medicine, Changchun, China., Wang X; Jilin Institute for Drug Control, Changchun, China., Wang X; College of Food Science and Engineering, Northwest A&F University, Yangling, Shanxi, PR China., Xu X; Huanan Agricultural Technology Extension Center, Huarong, China., Ma C; Sichuan Tianzow Breeding Co., Ltd, Chongqing, China., Wang J; Department of Digestive, China-Japan Union Hospital Affiliated to Jilin University, Changchun, China. |
المصدر: | Medicine [Medicine (Baltimore)] 2023 Oct 27; Vol. 102 (43), pp. e35508. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 2985248R Publication Model: Print Cited Medium: Internet ISSN: 1536-5964 (Electronic) Linking ISSN: 00257974 NLM ISO Abbreviation: Medicine (Baltimore) Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Hagerstown, Md : Lippincott Williams & Wilkins |
مواضيع طبية MeSH: | Ribavirin*/therapeutic use , Hepatitis C, Chronic*/drug therapy , Hepatitis C, Chronic*/genetics, Humans ; Antiviral Agents/therapeutic use ; Follow-Up Studies ; Treatment Outcome ; Pyrophosphatases/genetics ; Interferons/therapeutic use ; Polymorphism, Single Nucleotide ; Genotype ; Hepacivirus/genetics ; Liver Cirrhosis/drug therapy ; Liver Cirrhosis/genetics ; Liver Cirrhosis/chemically induced ; Interleukins/genetics ; Inosine Triphosphatase |
مستخلص: | To investigate associations between inosine triphosphatase (ITPA) gene polymorphisms and long-term outcomes among chronic hepatitis C (CHC) patients in Northeast China treated with Peg-interferon (IFN)/ribavirin (RBV). CHC patients who received Peg-IFN-2a/RBV treatment during between 2011 and 2013 at 5 hepatitis centers in Northeast China were enrolled. ITPA single nucleotide polymorphisms rs1127354 and rs7270101 from all patients were detected and their associations with 5-year outcomes were analyzed. A total of 635 patients, including 421 infected with hepatitis C virus (HCV) genotype 1 and 214 infected with non-genotype 1 were included. No significant differences were observed in the distribution frequencies of ITPA rs1127354 variants and ITPase activity between patients with HCV genotype 1 and non-genotype 1. In patients who received more than 80% of the planned RBV dose, the 5-year virological response rate and the improvement in liver fibrosis were higher in those with ITPA rs1127354 non-CC with ITPase activity <25% compared with these outcomes in patients with ITPA rs1127354 CC with 100% ITPase activity. Multiple regression analysis revealed that HCV genotype non-1, low baseline HCV ribose nucleic acid (RNA) levels (≤4 × 105 IU/mL), interleukin-28B rs12979860 CC genotype, low baseline liver fibrosis (Fibroscan 0-2), and ITPA rs1127354 non-CC genotype were independent predictors for a high long-term virological response rate, whereas interleukin-28B rs12979860 CC genotype, ITPA rs1127354 non-CC genotype, and low baseline liver fibrosis were independent predictors for improvement of liver fibrosis. ITPA rs1127354 polymorphisms is predictors of long-term outcomes in CHC patients treated with Peg-IFN/RBV. Competing Interests: The authors have no funding and conflicts of interest to disclose. (Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.) |
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المشرفين على المادة: | 49717AWG6K (Ribavirin) 0 (Antiviral Agents) EC 3.6.1.- (Pyrophosphatases) 9008-11-1 (Interferons) 0 (Interleukins) EC 3.6.1.9 (ITPA protein, human) |
تواريخ الأحداث: | Date Created: 20231031 Date Completed: 20231102 Latest Revision: 20240208 |
رمز التحديث: | 20240208 |
مُعرف محوري في PubMed: | PMC10615403 |
DOI: | 10.1097/MD.0000000000035508 |
PMID: | 37904484 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1536-5964 |
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DOI: | 10.1097/MD.0000000000035508 |