دورية أكاديمية
أعرض في EDS

Alterations in glutamate, arginine, and energy metabolism characterize cerebrospinal fluid and plasma metabolome of persons with HIV-associated dementia.

التفاصيل البيبلوغرافية
العنوان: Alterations in glutamate, arginine, and energy metabolism characterize cerebrospinal fluid and plasma metabolome of persons with HIV-associated dementia.
المؤلفون: Mastrangelo A; Vita-Salute San Raffaele University.; Centre Hopitalier Universitaire Vaudoise (CHUV), Lausanne, Switzerland., Scotti GM; Center for Omics Sciences, IRCCS Ospedale San Raffaele, Milan, Italy., Manteiga JG; Center for Omics Sciences, IRCCS Ospedale San Raffaele, Milan, Italy., Gisslén M; Department of Infectious Diseases, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg.; Department of Infectious Diseases, Region Västra Götaland, Sahlgrenska University Hospital, Gothenburg, Sweden., Price RW; Department of Neurology, University of California San Francisco, San Francisco, CA, USA., Bestetti A; Unit of Neurovirology, IRCCS San Raffaele Scientific Institute.; Unit of Infectious Diseases, IRCCS San Raffaele Scientific Institute., Turrini F; Unit of Neurovirology, IRCCS San Raffaele Scientific Institute., Caccia R; Unit of Neurovirology, IRCCS San Raffaele Scientific Institute.; Division of Genetics and Cell Biology, IRCCS San Raffaele University, Milan, Italy., Gorelik L; Fortress Biotech, Waltham, MA, USA., Morelli MJ; Center for Omics Sciences, IRCCS Ospedale San Raffaele, Milan, Italy., Castagna A; Vita-Salute San Raffaele University.; Unit of Infectious Diseases, IRCCS San Raffaele Scientific Institute., Cinque P; Unit of Neurovirology, IRCCS San Raffaele Scientific Institute.; Unit of Infectious Diseases, IRCCS San Raffaele Scientific Institute.
المصدر: AIDS (London, England) [AIDS] 2024 Mar 01; Vol. 38 (3), pp. 299-308. Date of Electronic Publication: 2023 Oct 27.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Lippincott Williams & Wilkins Country of Publication: England NLM ID: 8710219 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1473-5571 (Electronic) Linking ISSN: 02699370 NLM ISO Abbreviation: AIDS Subsets: MEDLINE
أسماء مطبوعة: Publication: 1998- : London, England : Lippincott Williams & Wilkins
Original Publication: London : Gower Academic Journals, c1987-
مواضيع طبية MeSH: HIV Infections*/complications , HIV Infections*/drug therapy , AIDS Dementia Complex*, Humans ; Arginine/metabolism ; Glutamic Acid/metabolism ; Glutamic Acid/therapeutic use ; Cross-Sectional Studies ; Metabolome ; Metabolomics/methods ; Energy Metabolism ; Biomarkers
مستخلص: Objectives: HIV-associated dementia (HAD) is the most severe clinical expression of HIV-mediated neuropathology, and the processes underlying its development remain poorly understood. We aimed to exploit high-dimensional metabolic profiling to gain insights into the pathological mechanisms associated to HAD.
Design: In this cross-sectional study, we utilized metabolomics to profile matched cerebrospinal fluid (CSF) and plasma samples of HAD individuals ( n  = 20) compared with neurologically asymptomatic people with HIV (ASYM, n  = 20) and healthy controls (NEG, n  = 20).
Methods: Identification of plasma and CSF metabolites was performed by liquid-chromatography or gas-chromatography following a validated experimental pipeline. The resulting metabolic profiles were analyzed by machine-learning algorithms, and altered pathways were identified by comparison with KEGG pathway database.
Results: In CSF, HAD patients displayed an imbalance in glutamine/glutamate ratio, decreased levels of isocitrate and arginine, and increased oxidative stress when compared with ASYM or NEG. These changes were confirmed in matched plasma samples, which in addition revealed an accumulation of eicosanoids and unsaturated fatty acids in HAD individuals. Pathway analysis in both biological fluids suggested that alterations in several metabolic processes, including protein biosynthesis, glutamate and arginine metabolism, and energy metabolism, in association to a perturbed eicosanoid metabolism in plasma, may represent the metabolic signature associated to HAD.
Conclusion: These findings show that HAD may be associated with metabolic modifications in CSF and plasma. These preliminary data may be useful to identify novel metabolic biomarkers and therapeutic targets in HIV-associated neurological impairment.
(Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.)
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المشرفين على المادة: 94ZLA3W45F (Arginine)
3KX376GY7L (Glutamic Acid)
0 (Biomarkers)
تواريخ الأحداث: Date Created: 20231031 Date Completed: 20240202 Latest Revision: 20240705
رمز التحديث: 20240706
DOI: 10.1097/QAD.0000000000003773
PMID: 37905996
قاعدة البيانات: MEDLINE
الوصف
تدمد:1473-5571
DOI:10.1097/QAD.0000000000003773