دورية أكاديمية
Folic acid grafted mixed polymeric micelles as a targeted delivery strategy for tamoxifen citrate in treatment of breast cancer.
| العنوان: | Folic acid grafted mixed polymeric micelles as a targeted delivery strategy for tamoxifen citrate in treatment of breast cancer. |
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| المؤلفون: | Nasr M; Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Helwan University, Cairo, 11790, Egypt. m2nasr@yahoo.com.; Department of Pharmaceutics, Faculty of Pharmacy, Delta University for Science and Technology, Gamasa, 11152, Egypt. m2nasr@yahoo.com., Hashem F; Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Helwan University, Cairo, 11790, Egypt., Teiama M; Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Helwan University, Cairo, 11790, Egypt.; Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Galala University, Attaka, 43713, Suez, Egypt., Tantawy N; Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Helwan University, Cairo, 11790, Egypt., Abdelmoniem R; Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Helwan University, Cairo, 11790, Egypt. |
| المصدر: | Drug delivery and translational research [Drug Deliv Transl Res] 2024 Apr; Vol. 14 (4), pp. 945-958. Date of Electronic Publication: 2023 Oct 31. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer Country of Publication: United States NLM ID: 101540061 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2190-3948 (Electronic) Linking ISSN: 2190393X NLM ISO Abbreviation: Drug Deliv Transl Res Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: New York : Springer |
| مواضيع طبية MeSH: | Micelles* , Neoplasms*, Mice ; Animals ; Tamoxifen ; Folic Acid/chemistry ; Poloxalene/chemistry ; Cell Line, Tumor ; Polymers/chemistry ; Drug Carriers/chemistry |
| مستخلص: | The objective of this study was to develop folic acid (FA) grafted mixed polymeric micelles loaded with Tamoxifen citrate (TMXC) to enhance its antitumor activity in breast tissues. The conjugated folic acid Pluronic 123 (FA-P123) was prepared using carbonyl diimidazole cross-linker chemistry and confirmed using FTIR and 1 HNMR. TMXC-loaded P123/P84 (unconjugated) and TMXC-loaded FA-P123/P84 (conjugated) micelles were examined for encapsulation efficiency, particle size, surface charge, in vitro drug release, cytotoxic effect, and cellular uptake by a breast cancer cell line. The conjugated TMXC-loaded micelle exhibited a nanoparticle size of 35.01 ± 1.20 nm, a surface charge of-20.50 ± 0.95 mV, entrapped 87.83 ± 5.10% and released 67.58 ± 2.47% of TMXC after 36 h. The conjugated micelles exhibited a significantly higher cellular uptake of TMXC by the MCF-7 cell line and improved in vitro cytotoxicity by 2.48 folds compared to the TMXC-loaded unconjugated micelles. The results of in vivo studies indicated that TMXC-loaded FA-P123/P84 has a potential antitumor activity, as revealed by a significant reduction of tumor volume in tumor-bearing mice compared to TMXC-loaded unconjugated micelles. In conclusion, the obtained results suggested that conjugated FA-P123/P84 micelles could be an encouraging carrier for the treatment of breast cancer with TMXC. (© 2023. The Author(s).) |
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| فهرسة مساهمة: | Keywords: Antitumor activity; Folic acid; Mixed polymeric micelles; Pluronic copolymers; Tamoxifen citrate; Targeting breast cancer |
| المشرفين على المادة: | 0 (Micelles) 094ZI81Y45 (Tamoxifen) 935E97BOY8 (Folic Acid) 9003-11-6 (Poloxalene) 0 (Polymers) 0 (Drug Carriers) |
| تواريخ الأحداث: | Date Created: 20231031 Date Completed: 20240312 Latest Revision: 20240314 |
| رمز التحديث: | 20240314 |
| مُعرف محوري في PubMed: | PMC10927891 |
| DOI: | 10.1007/s13346-023-01443-3 |
| PMID: | 37906415 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 2190-3948 |
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| DOI: | 10.1007/s13346-023-01443-3 |