دورية أكاديمية

أعرض في EDS

Continually recruited naïve T cells contribute to the follicular helper and regulatory T cell pools in germinal centers.

التفاصيل البيبلوغرافية
العنوان:	Continually recruited naïve T cells contribute to the follicular helper and regulatory T cell pools in germinal centers.
المؤلفون:	Merkenschlager J; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, 10065, USA. jmerkensch@rockefeller.edu., Berz RM; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, 10065, USA., Ramos V; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, 10065, USA., Uhlig M; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, 10065, USA., MacLean AJ; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, 10065, USA., Nowosad CR; Translational Immunology Center, New York University Grossman School of Medicine, New York, NY, 10016, USA., Oliveira TY; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, 10065, USA., Nussenzweig MC; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY, 10065, USA.; Howard Hughes Medical Institute, The Rockefeller University, New York, NY, 10065, USA.
المصدر:	Nature communications [Nat Commun] 2023 Oct 31; Vol. 14 (1), pp. 6944. Date of Electronic Publication: 2023 Oct 31.
نوع المنشور:	Journal Article; Research Support, N.I.H., Extramural
اللغة:	English
بيانات الدورية:	Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
أسماء مطبوعة:	Original Publication: [London] : Nature Pub. Group
مواضيع طبية MeSH:	T-Lymphocytes, Regulatory* , T-Lymphocytes, Helper-Inducer*, Germinal Center ; B-Lymphocytes ; Antigens
مستخلص:	Follicular helper T cells (T FH ) mediate B cell selection and clonal expansion in germinal centers (GCs), and follicular regulatory T cells (T FR ) prevent the emergence of self-reactive B cells and help to extinguish the reaction. Here we show that GC reactions continually recruit T cells from both the naïve conventional and naive thymic regulatory T cell (Treg) repertoires. In the early GC, newly recruited T cells develop into T FH , whereas cells entering during the contraction phase develop into T FR cells that contribute to GC dissolution. The T FR fate decision is associated with decreased antigen availability and is modulated by slow antigen delivery or mRNA vaccination. Thus, invasion of ongoing GCs by newly developing T FH and T FR helps remodel the GC based on antigen availability. (© 2023. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.)
References:	Science. 2016 Mar 4;351(6277):1048-54. (PMID: 26912368) Science. 2015 Aug 7;349(6248):643-6. (PMID: 26184917) Nat Commun. 2016 Jan 05;7:10281. (PMID: 26728651) Annu Rev Immunol. 2022 Apr 26;40:413-442. (PMID: 35113731) Nature. 2021 Aug;596(7870):109-113. (PMID: 34182569) Annu Rev Immunol. 2012;30:429-57. (PMID: 22224772) Immunity. 2007 Aug;27(2):190-202. (PMID: 17723214) Cell. 2021 Apr 1;184(7):1775-1789.e19. (PMID: 33711260) Biochemistry. 1964 Jul;3:996-1008. (PMID: 14214095) Immunol Rev. 2019 Mar;288(1):112-127. (PMID: 30874344) Nature. 2022 Sep;609(7929):998-1004. (PMID: 36131022) J Exp Med. 2006 Oct 30;203(11):2419-24. (PMID: 17030950) Curr Opin Immunol. 2017 Apr;45:21-30. (PMID: 28088708) Autoimmunity. 2017 Feb;50(1):4-18. (PMID: 28166685) Immunity. 1998 Jun;8(6):751-9. (PMID: 9655489) Annu Rev Immunol. 2008;26:741-66. (PMID: 18173374) Cell. 2022 Mar 17;185(6):1025-1040.e14. (PMID: 35148837) Nature. 1996 Jun 27;381(6585):751-8. (PMID: 8657279) Science. 2013 Aug 9;341(6146):673-7. (PMID: 23887872) Immunol Rev. 2019 Mar;288(1):85-96. (PMID: 30874350) Science. 2021 Jul 16;373(6552):. (PMID: 34437125) Nat Immunol. 2009 Apr;10(4):385-93. (PMID: 19252490) Nature. 2021 Mar;591(7850):458-463. (PMID: 33536617) Nat Commun. 2016 Jan 28;7:10579. (PMID: 26818004) Nature. 2014 May 29;509(7502):637-40. (PMID: 24805232) Nat Rev Immunol. 2014 Jul;14(7):495-504. (PMID: 24948364) Nature. 2001 May 24;411(6836):489-94. (PMID: 11373683) Front Immunol. 2021 Jul 07;12:705240. (PMID: 34305944) Cell. 2023 Jan 5;186(1):147-161.e15. (PMID: 36565698) J Exp Med. 2018 Mar 5;215(3):815-825. (PMID: 29378778) PLoS Biol. 2005 Jun;3(6):e150. (PMID: 15857154) J Exp Med. 2011 Jun 6;208(6):1243-52. (PMID: 21576382) Immunity. 2018 Apr 17;48(4):702-715.e4. (PMID: 29669250) J Immunol. 2011 Nov 1;187(9):4553-60. (PMID: 21984700) Front Immunol. 2021 Jun 10;12:679909. (PMID: 34177925) Immunity. 2019 May 21;50(5):1132-1148. (PMID: 31117010) Cell. 2020 Jan 9;180(1):206. (PMID: 31923396) J Exp Med. 2017 May 1;214(5):1259-1267. (PMID: 28363897) Cell. 2019 May 16;177(5):1153-1171.e28. (PMID: 31080066) Nat Med. 2011 Jul 24;17(8):975-82. (PMID: 21785433) Cancer Immunol Res. 2014 May;2(5):381-92. (PMID: 24795350) Cell. 2010 Nov 12;143(4):592-605. (PMID: 21074050) Nat Immunol. 2019 Oct;20(10):1360-1371. (PMID: 31477921)
معلومات مُعتمدة:	R37 AI037526 United States AI NIAID NIH HHS; UM1 AI144462 United States AI NIAID NIH HHS
المشرفين على المادة:	0 (Antigens)
تواريخ الأحداث:	Date Created: 20231101 Date Completed: 20231102 Latest Revision: 20240210
رمز التحديث:	20240210
مُعرف محوري في PubMed:	PMC10618265
DOI:	10.1038/s41467-023-41880-9
PMID:	37907454
قاعدة البيانات:	MEDLINE

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تدمد:	2041-1723
DOI:	10.1038/s41467-023-41880-9