دورية أكاديمية
أعرض في EDS

Sensing the oxygen and temperature in the adipose tissues - who's sensing what?

التفاصيل البيبلوغرافية
العنوان: Sensing the oxygen and temperature in the adipose tissues - who's sensing what?
المؤلفون: Kang GS; College of Veterinary Medicine, Seoul National University, 1 Gwanak-Ro, Gwanak-Gu, Seoul, 08826, Korea., Jo HJ; College of Veterinary Medicine, Seoul National University, 1 Gwanak-Ro, Gwanak-Gu, Seoul, 08826, Korea., Lee YR; College of Veterinary Medicine, Seoul National University, 1 Gwanak-Ro, Gwanak-Gu, Seoul, 08826, Korea., Oh T; College of Veterinary Medicine, Seoul National University, 1 Gwanak-Ro, Gwanak-Gu, Seoul, 08826, Korea., Park HJ; College of Medicine, Seoul National University, 1 Gwanak-Ro, Gwanak-Gu, Seoul, 08826, Korea., Ahn GO; College of Veterinary Medicine, Seoul National University, 1 Gwanak-Ro, Gwanak-Gu, Seoul, 08826, Korea. goneahn@snu.ac.kr.; College of Medicine, Seoul National University, 1 Gwanak-Ro, Gwanak-Gu, Seoul, 08826, Korea. goneahn@snu.ac.kr.
المصدر: Experimental & molecular medicine [Exp Mol Med] 2023 Nov; Vol. 55 (11), pp. 2300-2307. Date of Electronic Publication: 2023 Nov 01.
نوع المنشور: Journal Article; Review; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 9607880 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2092-6413 (Electronic) Linking ISSN: 12263613 NLM ISO Abbreviation: Exp Mol Med Subsets: MEDLINE
أسماء مطبوعة: Publication: Jan. 2013- : New York : Nature Publishing Group
Original Publication: Seoul : Korean Society of Medical Biochemistry and Molecular Biology, 1996-
مواضيع طبية MeSH: Oxygen*/metabolism , Endothelial Cells*/metabolism, Mice ; Animals ; Temperature ; Thermogenesis ; Adipose Tissue, Brown/metabolism ; Adipose Tissue, White/metabolism ; Obesity/metabolism ; Hypoxia/metabolism ; Mice, Inbred C57BL
مستخلص: Adipose tissues, composed of various cell types, including adipocytes, endothelial cells, neurons, and immune cells, are organs that are exposed to dynamic environmental challenges. During diet-induced obesity, white adipose tissues experience hypoxia due to adipocyte hypertrophy and dysfunctional vasculature. Under these conditions, cells in white adipose tissues activate hypoxia-inducible factor (HIF), a transcription factor that activates signaling pathways involved in metabolism, angiogenesis, and survival/apoptosis to adapt to such an environment. Exposure to cold or activation of the β-adrenergic receptor (through catecholamines or chemicals) leads to heat generation, mainly in brown adipose tissues through activating uncoupling protein 1 (UCP1), a proton uncoupler in the inner membrane of the mitochondria. White adipose tissues can undergo a similar process under this condition, a phenomenon known as 'browning' of white adipose tissues or 'beige adipocytes'. While UCP1 expression has largely been confined to adipocytes, HIF can be expressed in many types of cells. To dissect the role of HIF in specific types of cells during diet-induced obesity, researchers have generated tissue-specific knockout (KO) mice targeting HIF pathways, and many studies have commonly revealed that intact HIF-1 signaling in adipocytes and adipose tissue macrophages exacerbates tissue inflammation and insulin resistance. In this review, we highlight some of the key findings obtained from these transgenic mice, including Ucp1 KO mice and other models targeting the HIF pathway in adipocytes, macrophages, or endothelial cells, to decipher their roles in diet-induced obesity.
(© 2023. The Author(s).)
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معلومات مُعتمدة: NRF-2020R1A2C2100934 National Research Foundation of Korea (NRF); NRF-2020M2D9A2092374 National Research Foundation of Korea (NRF); NRF-2021K1A3A1A17086250 National Research Foundation of Korea (NRF)
المشرفين على المادة: S88TT14065 (Oxygen)
تواريخ الأحداث: Date Created: 20231101 Date Completed: 20231204 Latest Revision: 20240121
رمز التحديث: 20240121
مُعرف محوري في PubMed: PMC10689767
DOI: 10.1038/s12276-023-01113-x
PMID: 37907745
قاعدة البيانات: MEDLINE
الوصف
تدمد:2092-6413
DOI:10.1038/s12276-023-01113-x