دورية أكاديمية
Hoffmann's syndrome in the differential work-up of myopathic complaints: a case report.
| العنوان: | Hoffmann's syndrome in the differential work-up of myopathic complaints: a case report. |
|---|---|
| المؤلفون: | Winter S; Department of Neurology, Jena University Hospital, Friedrich Schiller University, Am Klinikum 1, 07747, Jena, Germany., Heiling B; Department of Neurology, Jena University Hospital, Friedrich Schiller University, Am Klinikum 1, 07747, Jena, Germany.; Clinical Scientist Program OrganAge, Jena University Hospital, Jena, Germany., Eckardt N; Department of Radiology, Jena University Hospital, Friedrich Schiller University, Jena, Germany., Kloos C; Department of Internal Medicine III, Jena University Hospital, Friedrich Schiller University, Jena, Germany., Axer H; Department of Neurology, Jena University Hospital, Friedrich Schiller University, Am Klinikum 1, 07747, Jena, Germany. Hubertus.axer@med.uni-jena.de. |
| المصدر: | Journal of medical case reports [J Med Case Rep] 2023 Oct 31; Vol. 17 (1), pp. 473. Date of Electronic Publication: 2023 Oct 31. |
| نوع المنشور: | Case Reports; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: BioMed Central Country of Publication: England NLM ID: 101293382 Publication Model: Electronic Cited Medium: Internet ISSN: 1752-1947 (Electronic) Linking ISSN: 17521947 NLM ISO Abbreviation: J Med Case Rep Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [London] : BioMed Central, [2007- |
| مواضيع طبية MeSH: | Muscular Diseases*/diagnosis , Congenital Hypothyroidism*/complications, Male ; Adult ; Humans ; Middle Aged ; Myalgia ; Muscle Weakness/etiology ; Hypertrophy ; Thyrotropin |
| مستخلص: | Background: Hoffmann's syndrome is a rare form of hypothyroid myopathy in adults, which is mainly characterized by muscular weakness and muscular pseudohypertrophy. Case Presentation: We report about a 61-year-old Western European man with myalgia, myxedema and pseudohypertrophy of the calf muscles. Laboratory tests revealed significantly elevated thyroid stimulating hormone (TSH) and creatine kinase (CK). Muscle MRI showed muscular hypertrophy of the lower limbs, but no signs of myositis or myopathy (no gadolinium enhancement, no edema, no fatty degeneration). In addition, electromyography (EMG) detected spontaneous activity. After the beginning of thyroxin-therapy it took six months until the muscle weakness improved and the myalgia regressed. Conclusions: Here, we focus on diagnostic routines and typical findings to differentiate Hoffmann's syndrome from other myopathies. Clinical hallmarks of Hoffmann's syndrome are pseudohypertrophy and weakness of the calf muscles in combination with elevated CK and elevated TSH. EMG is well suited to detect the involvement of the muscles and muscle MRI helps to differentiate it from other myopathies. Hoffmann's syndrome is a rare myopathy due to hypothyroidism and plays a role in the differential diagnosis of myopathic complaints even if hypothyroidism has not been detected before. (© 2023. The Author(s).) |
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| معلومات مُعتمدة: | 413668513 Deutsche Forschungsgemeinschaft |
| فهرسة مساهمة: | Keywords: EMG; Hoffmann’s syndrome; Hypothyroidism; MRI; Muscle biopsy; Myopathy |
| المشرفين على المادة: | 9002-71-5 (Thyrotropin) |
| تواريخ الأحداث: | Date Created: 20231101 Date Completed: 20231102 Latest Revision: 20231103 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC10617199 |
| DOI: | 10.1186/s13256-023-04184-6 |
| PMID: | 37907975 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1752-1947 |
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| DOI: | 10.1186/s13256-023-04184-6 |