دورية أكاديمية
أعرض في EDS

Weight-loss Independent Clinical and Metabolic Biomarkers Associated with Type 2 Diabetes Remission Post-bariatric/metabolic Surgery.

التفاصيل البيبلوغرافية
العنوان: Weight-loss Independent Clinical and Metabolic Biomarkers Associated with Type 2 Diabetes Remission Post-bariatric/metabolic Surgery.
المؤلفون: Chaiyasoot K; Department of Medicine, Centre for Obesity Research, University College London, London, UK.; Division of Nutrition, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.; The Siriraj Center of Research Excellence for Diabetes and Obesity (SiCORE-DO), Mahidol University, Bangkok, Thailand., Sakai NS; UCL Centre for Medical Imaging, London, UK., Zakeri R; Department of Medicine, Centre for Obesity Research, University College London, London, UK., Makaronidis J; Department of Medicine, Centre for Obesity Research, University College London, London, UK.; National Institute of Health Research, University College London Hospitals Biomedical Research Centre, London, UK., Crisóstomo L; Department of Immunophysiology and Pharmacology, ICBAS - School of Medicine and Biomedical Sciences, UMIB - Unit for Multidisciplinary Research in Biomedicine, University of Porto, Porto, Portugal.; ITR - Laboratory for Integrative and Translational Research in Population Health, Porto, Portugal.; Institute of Biomedicine, University of Turku, Turku, Finland., Alves MG; Department of Immunophysiology and Pharmacology, ICBAS - School of Medicine and Biomedical Sciences, UMIB - Unit for Multidisciplinary Research in Biomedicine, University of Porto, Porto, Portugal.; ITR - Laboratory for Integrative and Translational Research in Population Health, Porto, Portugal., Gan W; Genetics Department, Novo Nordisk Research Centre Oxford, Innovation Building, Old Road Campus, Headington, OX37LQ, UK., Firman C; Department of Medicine, Centre for Obesity Research, University College London, London, UK., Jassil FC; Department of Medicine, Centre for Obesity Research, University College London, London, UK., Hall-Craggs MA; UCL Centre for Medical Imaging, London, UK.; National Institute of Health Research, University College London Hospitals Biomedical Research Centre, London, UK., Taylor SA; UCL Centre for Medical Imaging, London, UK.; National Institute of Health Research, University College London Hospitals Biomedical Research Centre, London, UK., Batterham RL; Department of Medicine, Centre for Obesity Research, University College London, London, UK. r.batterham@ucl.ac.uk.; National Institute of Health Research, University College London Hospitals Biomedical Research Centre, London, UK. r.batterham@ucl.ac.uk.
المصدر: Obesity surgery [Obes Surg] 2023 Dec; Vol. 33 (12), pp. 3988-3998. Date of Electronic Publication: 2023 Nov 01.
نوع المنشور: Observational Study; Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer Science + Business Media Country of Publication: United States NLM ID: 9106714 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1708-0428 (Electronic) Linking ISSN: 09608923 NLM ISO Abbreviation: Obes Surg Subsets: MEDLINE
أسماء مطبوعة: Publication: 2006- : New York : Springer Science + Business Media
Original Publication: Oxford, OX, UK : Rapid Communications of Oxford, [1991-
مواضيع طبية MeSH: Diabetes Mellitus, Type 2* , Obesity, Morbid*/surgery , Bariatric Surgery*, Humans ; Ghrelin ; Treatment Outcome ; Weight Loss ; Biomarkers
مستخلص: Purpose: Remission of type 2 diabetes (T2D) can be achieved by many, but not all, people following bariatric/metabolic surgery. The mechanisms underlying T2D remission remain incompletely understood. This observational study aimed to identify novel weight-loss independent clinical, metabolic and genetic factors that associate with T2D remission using comprehensive phenotyping.
Materials and Methods: Ten patients without T2D remission (non-remitters) were matched to 10 patients with T2D remission (remitters) for age, sex, type of surgery, body weight, BMI, post-operative weight loss, duration from surgery and duration of T2D. Detailed body composition assessed using magnetic resonance imaging, gut hormones, serum metabolomics, insulin sensitivity, and genetic risk scores for T2D and anthropometric traits were assessed.
Results: Remitters had significantly greater β-cell function and circulating acyl ghrelin levels, but lower visceral adipose tissue (VAT): subcutaneous adipose tissue (SAT) ratio than non-remitters. Branched-chain amino acids (BCAAs) and VLDL particle size were the most discriminant metabolites between groups. A significant positive correlation between, VAT area, VAT:SAT ratio and circulating levels of BCAAs was observed, whereas a significant negative correlation between BCAAs and β-cell function was revealed.
Conclusion: We highlight a potentially novel relationship between VAT and BCAAs, which may play a role in glucoregulatory control. Improvement in β-cell function, and the role ghrelin plays in its recovery, is likely another key factor influencing T2D remission post-surgery. These findings suggest that adjunctive approaches that target VAT loss and restoration of BCAA metabolism might achieve higher rates of long-term T2D remission post-surgery.
(© 2023. The Author(s).)
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معلومات مُعتمدة: CM710 Rosetrees Trust; RP-2015-06-005 National Institute for Health and Care Research
فهرسة مساهمة: Keywords: Metabolic surgery; Obesity; Remission; Type 2 diabetes
المشرفين على المادة: 0 (Ghrelin)
0 (Biomarkers)
تواريخ الأحداث: Date Created: 20231101 Date Completed: 20231130 Latest Revision: 20231201
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC10687127
DOI: 10.1007/s11695-023-06905-8
PMID: 37910328
قاعدة البيانات: MEDLINE
الوصف
تدمد:1708-0428
DOI:10.1007/s11695-023-06905-8