دورية أكاديمية
أعرض في EDS

Posttransplant Tertiary Lymphoid Organs.

التفاصيل البيبلوغرافية
العنوان: Posttransplant Tertiary Lymphoid Organs.
المؤلفون: Ruddle NH; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT.
المصدر: Transplantation [Transplantation] 2024 May 01; Vol. 108 (5), pp. 1090-1099. Date of Electronic Publication: 2023 Nov 02.
نوع المنشور: Journal Article; Review; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 0132144 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1534-6080 (Electronic) Linking ISSN: 00411337 NLM ISO Abbreviation: Transplantation Subsets: MEDLINE
أسماء مطبوعة: Publication: Hagerstown, MD : Lippincott Williams & Wilkins
Original Publication: Baltimore, Williams & Wilkins.
مواضيع طبية MeSH: Tertiary Lymphoid Structures*/immunology , Tertiary Lymphoid Structures*/pathology , Graft Rejection*/immunology , Graft Rejection*/prevention & control , Organ Transplantation*/adverse effects, Humans ; Animals
مستخلص: Tertiary lymphoid organs (TLOs), also known as tertiary or ectopic lymphoid structures or tissues, are accumulations of lymphoid cells in sites other than canonical lymphoid organs, that arise through lymphoid neogenesis during chronic inflammation in autoimmunity, microbial infection, cancer, aging, and transplantation, the focus of this review. Lymph nodes and TLOs are compared regarding their cellular composition, organization, vascular components, and migratory signal regulation. These characteristics of posttransplant TLOs (PT-TLOs) are described with individual examples in a wide range of organs including heart, kidney, trachea, lung, artery, skin, leg, hand, and face, in many species including human, mouse, rat, and monkey. The requirements for induction and maintenance of TLOs include sustained exposure to autoantigens, alloantigens, tumor antigens, ischemic reperfusion, nephrotoxic agents, and aging. Several staging schemes have been put forth regarding their function in organ rejection. PT-TLOs most often are associated with organ rejection, but in some cases contribute to tolerance. The role of PT-TLOs in cancer is considered in the case of immunosuppression. Furthermore, TLOs can be associated with development of lymphomas. Challenges for PT-TLO research are considered regarding staging, imaging, and opportunities for their therapeutic manipulation to inhibit rejection and encourage tolerance.
Competing Interests: The author declares no conflict of interest.
(Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc.)
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معلومات مُعتمدة: NIH; National Multiple Sclerosis Society
تواريخ الأحداث: Date Created: 20231102 Date Completed: 20240425 Latest Revision: 20240528
رمز التحديث: 20240528
مُعرف محوري في PubMed: PMC11042531
DOI: 10.1097/TP.0000000000004812
PMID: 37917987
قاعدة البيانات: MEDLINE
الوصف
تدمد:1534-6080
DOI:10.1097/TP.0000000000004812