دورية أكاديمية
أعرض في EDS

Desmarestia anceps Montagne modulates inflammatory response in experimental periodontitis in male Wistar rats.

التفاصيل البيبلوغرافية
العنوان: Desmarestia anceps Montagne modulates inflammatory response in experimental periodontitis in male Wistar rats.
المؤلفون: Verzeletti GN; Biotechnology Institute, University of Caxias do Sul, Rua Francisco Getúlio Vargas, 1130, Caxias do Sul, RS 95070-560, Brazil; School of Dentistry, Department of Periodontology, University of Caxias do Sul, Rua Francisco Getúlio Vargas, 1130 Bloco S, Caxias do Sul, RS 95070-560, Brazil. Electronic address: gnverzeletti@ucs.br., Gaio EJ; Department of Periodontology, Federal University of Rio Grande do Sul, Porto Alegre, Brazil., Machado KG; Biotechnology Institute, University of Caxias do Sul, Rua Francisco Getúlio Vargas, 1130, Caxias do Sul, RS 95070-560, Brazil., Spuldaro TR; Department of Periodontology, Federal University of Rio Grande do Sul, Porto Alegre, Brazil., Demeda CF; School of Dentistry, Department of Periodontology, University of Caxias do Sul, Rua Francisco Getúlio Vargas, 1130 Bloco S, Caxias do Sul, RS 95070-560, Brazil., Frassini R; Biotechnology Institute, University of Caxias do Sul, Rua Francisco Getúlio Vargas, 1130, Caxias do Sul, RS 95070-560, Brazil., Streck AF; Biotechnology Institute, University of Caxias do Sul, Rua Francisco Getúlio Vargas, 1130, Caxias do Sul, RS 95070-560, Brazil., Moura E Silva S; Biotechnology Institute, University of Caxias do Sul, Rua Francisco Getúlio Vargas, 1130, Caxias do Sul, RS 95070-560, Brazil., Rösing CK; Department of Periodontology, Federal University of Rio Grande do Sul, Porto Alegre, Brazil., Henriques JAP; Biotechnology Institute, University of Caxias do Sul, Rua Francisco Getúlio Vargas, 1130, Caxias do Sul, RS 95070-560, Brazil., Roesch-Ely M; Biotechnology Institute, University of Caxias do Sul, Rua Francisco Getúlio Vargas, 1130, Caxias do Sul, RS 95070-560, Brazil.
المصدر: Archives of oral biology [Arch Oral Biol] 2024 Jan; Vol. 157, pp. 105825. Date of Electronic Publication: 2023 Oct 17.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Pergamon Press Country of Publication: England NLM ID: 0116711 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1506 (Electronic) Linking ISSN: 00039969 NLM ISO Abbreviation: Arch Oral Biol Subsets: MEDLINE
أسماء مطبوعة: Publication: Oxford : Pergamon Press
Original Publication: Oxford, New York [etc.] Pergamon Press.
مواضيع طبية MeSH: Alveolar Bone Loss*/drug therapy , Periodontitis*/metabolism, Rats ; Male ; Animals ; Rats, Wistar ; Tumor Necrosis Factor-alpha/metabolism ; Antioxidants/therapeutic use ; Interleukin-1beta/metabolism
مستخلص: Objective: Desmarestia anceps Montagne (D. anceps) seaweed has been shown to play a range of biologic activities, such as anti-inflammatory and antioxidant properties. The purpose of this study was to investigate the effects of D. anceps on pathogenesis of ligature-induced experimental periodontitis in rats.
Design: Fifty-four male Wistar rats were randomly divided into six groups. Doses of D. anceps (100 and 200 mg/kg) were administered for 14 days to animals with or without ligature-induced periodontitis, in order to compare to control groups (vehicle solution). Morphometric registration of alveolar bone loss and histological analysis were conducted. Inflammatory cells were counted on hematoxylin-eosin-stained slides. Immunohistochemical expressions for interleukin-1 beta (IL-1β), tumor necrosis factor (TNF-α), receptor activator of nuclear factor kappa-Β ligand (RANKL) and bone morphogenetic protein 2 (BMP-2) were evaluated.
Results: Alveolar bone loss was higher in groups exposed to ligature-induced periodontitis, but no significant differences were observed comparing different treatment and control groups. Animals that received D. anceps extracts showed significant lower counts of inflammatory cells. D. anceps promoted increased expression of BMP-2 and inhibited IL-1β, TNF-α and RANKL.
Conclusion: D. anceps modulates inflammatory response in experimental periodontitis in rats. Further pharmacological and immunological analyses are warranted.
Competing Interests: Declaration of Competing Interest All authors of this research (Giliano Nicolini Verzeletti, Eduardo José Gaio, Keilla Gomes Machado, Tobias Rauber Spuldaro, Clarissa Favero Demeda, Rafaele Frassini, André Felipe Streck, Sidnei Moura e Silva, Cassiano Kuchenbecker Rösing, João Antonio Pêgas Henriques and Mariana Roesch-Ely) declare no conflict of interest.
(Copyright © 2023 Elsevier Ltd. All rights reserved.)
فهرسة مساهمة: Keywords: Inflammation; Periodontal disease; Seaweed
المشرفين على المادة: 0 (Tumor Necrosis Factor-alpha)
0 (Antioxidants)
0 (Interleukin-1beta)
تواريخ الأحداث: Date Created: 20231102 Date Completed: 20231205 Latest Revision: 20231205
رمز التحديث: 20231215
DOI: 10.1016/j.archoralbio.2023.105825
PMID: 37918302
قاعدة البيانات: MEDLINE
الوصف
تدمد:1879-1506
DOI:10.1016/j.archoralbio.2023.105825