دورية أكاديمية
Hospitalizations after Renal Transplantation in Children: Risk Factors, Causes, and Outcomes.
| العنوان: | Hospitalizations after Renal Transplantation in Children: Risk Factors, Causes, and Outcomes. |
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| المؤلفون: | Yılmaz S; Department of Pediatrics, Division of Pediatric Nephrology, Ankara University School of Medicine, Ankara, Turkey, songulyilmaz23@gmail.com., Özçakar ZB; Department of Pediatrics, Division of Pediatric Nephrology, Ankara University School of Medicine, Ankara, Turkey., Çakar N; Department of Pediatrics, Division of Pediatric Nephrology, Ankara University School of Medicine, Ankara, Turkey., Biral Coşkun B; Department of Pediatrics, Division of Pediatric Nephrology, Ankara University School of Medicine, Ankara, Turkey., Yalçınkaya FF; Department of Pediatrics, Division of Pediatric Nephrology, Ankara University School of Medicine, Ankara, Turkey. |
| المصدر: | Nephron [Nephron] 2024; Vol. 148 (3), pp. 185-194. Date of Electronic Publication: 2023 Nov 02. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Karger Country of Publication: Switzerland NLM ID: 0331777 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2235-3186 (Electronic) Linking ISSN: 16608151 NLM ISO Abbreviation: Nephron Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Basel ; New York : Karger |
| مواضيع طبية MeSH: | Kidney Transplantation*/adverse effects , Urogenital Abnormalities* , Vesico-Ureteral Reflux*, Male ; Humans ; Child ; Retrospective Studies ; Graft Rejection ; Risk Factors ; Hospitalization |
| مستخلص: | Introduction: The aims of this study were to evaluate the frequency and causes of hospitalizations in the posttransplant period of children, investigate the risk factors, and evaluate the relationship between hospitalizations and renal prognosis in the long term. Methods: We retrospectively reviewed the files of pediatric renal transplant patients, followed at least 6 months after kidney transplantation, in our center. Clinical information including age at transplantation, gender, primary disease, donor type, immuno-suppressive medication, hospitalization dates, and indications (infections and non-infectious) during follow-up period and graft outcomes was recorded. Results: A total of 74 children (46 males) were followed up for a median of 54 months. Among them, 69 patients (93.2%) were hospitalized 446 times. The most common cause of hospitalizations was infections (314 times, 70%). Urinary tract infections were the most important cause followed by upper respiratory tract infections. Forty (54%) patients were hospitalized 132 times (29.5%) for non-infectious reasons. The most common non-infectious reason was nonspecific graft dysfunction (19 patients, 30 times), followed by rejection (17 patients, 27 times). Younger age, use of induction therapy, and having congenital anomalies of kidney and urinary tract (CAKUT) were found to be risk factors for increased hospitalization rates (p < 0.05). The number of hospitalizations was found to be negatively affecting the final glomerular filtration rate of transplant recipients (p: 0.04, r: -0.023). Conclusion: Patients with CAKUT, who received induction therapy, and small children were hospitalized more frequently after transplantation. Strategies to prevent hospitalizations will achieve a better graft prognosis. (© 2023 S. Karger AG, Basel.) |
| فهرسة مساهمة: | Keywords: Hospitalization; Infection; Kidney transplantation; Pediatric nephrology |
| SCR Disease Name: | Cakut |
| تواريخ الأحداث: | Date Created: 20231102 Date Completed: 20240305 Latest Revision: 20240429 |
| رمز التحديث: | 20240430 |
| DOI: | 10.1159/000534787 |
| PMID: | 37918365 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2235-3186 |
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| DOI: | 10.1159/000534787 |