دورية أكاديمية
Vitamin A deficiency retinopathy related to medical interventions in a Swiss cohort: a case series.
| العنوان: | Vitamin A deficiency retinopathy related to medical interventions in a Swiss cohort: a case series. |
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| المؤلفون: | Gunzinger JM; The Save Sight Institute, The University of Sydney, Sydney, Australia., Muth DR; The Save Sight Institute, The University of Sydney, Sydney, Australia., Hanson JVM; The Save Sight Institute, The University of Sydney, Sydney, Australia., Al-Sheikh M; The Save Sight Institute, The University of Sydney, Sydney, Australia., Fasler K; The Save Sight Institute, The University of Sydney, Sydney, Australia., Barthelmes D; The Save Sight Institute, The University of Sydney, Sydney, Australia.; Department of Ophthalmology, University Hospital Zurich, University of Zurich, Zurich, Switzerland., Zweifel SA; The Save Sight Institute, The University of Sydney, Sydney, Australia. |
| المصدر: | Swiss medical weekly [Swiss Med Wkly] 2023 Nov 01; Vol. 153, pp. 40097. Date of Electronic Publication: 2023 Nov 01. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Trägerverein Swiss Medical Weekly SMW Country of Publication: Switzerland NLM ID: 100970884 Publication Model: Electronic Cited Medium: Internet ISSN: 1424-3997 (Electronic) Linking ISSN: 00367672 NLM ISO Abbreviation: Swiss Med Wkly Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2022- : Basel, Switzerland : Trägerverein Swiss Medical Weekly SMW Original Publication: Basel : EMH Swiss Medical Publishers Ltd., c2001- |
| مواضيع طبية MeSH: | Retinal Diseases*/complications , Vitamin A Deficiency*/complications , Vitamin A Deficiency*/diagnosis , Vitamin A Deficiency*/drug therapy, Adult ; Aged ; Aged, 80 and over ; Humans ; Middle Aged ; Young Adult ; Retrospective Studies ; Switzerland ; Vitamin A |
| مستخلص: | Aims of the Study: Vitamin A deficiency retinopathy is a potentially blinding disease. In developed countries, vitamin A deficiency due to malnutrition is rare. However, vitamin A deficiency can be caused by malabsorption resulting from bowel resection or medication. In this retrospective study, we present five cases of vitamin A deficiency retinopathy related to malabsorption secondary to medical interventions. Methods: Electronic charts over a ten-year period (2012-2022) were screened for vitamin A deficiency retinopathy. Only patients with vitamin A deficiency confirmed by laboratory tests were included. Symptoms, medical history, visual acuity, optical coherence tomography, fundus autofluorescence, electrophysiological examination, and vitamin A levels were reviewed. Results: Five eligible cases were identified. Median age was 44.7 years (range 22.2-88.9), median duration of ocular symptoms prior to diagnosis was 14 months, and median visual acuity was 1.0 (range 0.5-1.0, Snellen, decimal). Three patients had a history of bariatric surgery, one patient had a small bowel resection and was on octreotide treatment, and one patient suffered from cystic fibrosis and had a history of small bowel resection and severe hepatopathy. Optical coherence tomography showed various abnormalities, including a reduced interdigitation zone, subretinal drusenoid deposits, and a thinned outer nuclear layer. Electroretinogram findings ranged from abnormal oscillatory potentials to non-recordable rod responses. Conclusions: Vitamin A deficiency retinopathy can occur following medical interventions associated with malabsorption. In cases of night blindness, vitamin A levels should be measured. |
| المشرفين على المادة: | 11103-57-4 (Vitamin A) |
| تواريخ الأحداث: | Date Created: 20231103 Date Completed: 20231109 Latest Revision: 20231109 |
| رمز التحديث: | 20240628 |
| DOI: | 10.57187/smw.2023.40097 |
| PMID: | 37921090 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1424-3997 |
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| DOI: | 10.57187/smw.2023.40097 |