دورية أكاديمية
أعرض في EDS

Flagellar motors of swimming bacteria contain an incomplete set of stator units to ensure robust motility.

التفاصيل البيبلوغرافية
العنوان: Flagellar motors of swimming bacteria contain an incomplete set of stator units to ensure robust motility.
المؤلفون: Niu Y; Hefei National Research Center for Physical Sciences at the Microscale and Department of Physics, University of Science and Technology of China, Hefei, Anhui 230026, China., Zhang R; Hefei National Research Center for Physical Sciences at the Microscale and Department of Physics, University of Science and Technology of China, Hefei, Anhui 230026, China., Yuan J; Hefei National Research Center for Physical Sciences at the Microscale and Department of Physics, University of Science and Technology of China, Hefei, Anhui 230026, China.
المصدر: Science advances [Sci Adv] 2023 Nov 03; Vol. 9 (44), pp. eadi6724. Date of Electronic Publication: 2023 Nov 03.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Washington, DC : American Association for the Advancement of Science, [2015]-
مواضيع طبية MeSH: Swimming* , Molecular Motor Proteins*, Bacteria ; Escherichia coli/physiology ; Flagella/physiology ; Bacterial Proteins
مستخلص: Flagellated bacteria, like Escherichia coli , swim by rotating helical flagellar filaments powered by rotary flagellar motors at their base. Motor dynamics are sensitive to the load it drives. It was previously thought that motor load was high when driving filament rotation in free liquid environments. However, torque measurements from swimming bacteria revealed substantially lower values compared to single-motor studies. We addressed this inconsistency through motor resurrection experiments, abruptly attaching a 1-micrometer-diameter bead to the filament to ensure high load. Unexpectedly, we found that the motor works with only half the complement of stator units when driving filament rotation. This suggests that the motor is not under high load during bacterial swimming, which we confirmed by measuring the torque-speed relationship by varying media viscosity. Therefore, the motor operates in an intermediate-load region, adaptively regulating its stator number on the basis of external load conditions. This ensures the robustness of bacterial motility when swimming in diverse load conditions and varying flagella numbers.
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المشرفين على المادة: 0 (Molecular Motor Proteins)
0 (Bacterial Proteins)
تواريخ الأحداث: Date Created: 20231103 Date Completed: 20231106 Latest Revision: 20231124
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC10624342
DOI: 10.1126/sciadv.adi6724
PMID: 37922360
قاعدة البيانات: MEDLINE
الوصف
تدمد:2375-2548
DOI:10.1126/sciadv.adi6724