دورية أكاديمية
أعرض في EDS

Detecting recurrent disease and surgical outcomes in patients with locally advanced tongue cancer after multimodal treatment using ¹⁸F-FDG-PET/CT.

التفاصيل البيبلوغرافية
العنوان: Detecting recurrent disease and surgical outcomes in patients with locally advanced tongue cancer after multimodal treatment using ¹⁸F-FDG-PET/CT.
المؤلفون: Chen WL; Department of Oral and Maxillofacial Surgery, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou 510120, China. Electronic address: drchen@vip.163.com., Zhou B; Department of Oral and Maxillofacial Surgery, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou 510120, China., Huang ZX; Department of Oral and Maxillofacial Surgery, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou 510120, China., Dong XY; Department of Oral and Maxillofacial Surgery, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou 510120, China., Chen R; Department of Oral and Maxillofacial Surgery, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou 510120, China.
المصدر: Journal of stomatology, oral and maxillofacial surgery [J Stomatol Oral Maxillofac Surg] 2024 Jun; Vol. 125 (3), pp. 101673. Date of Electronic Publication: 2023 Nov 03.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Masson SAS Country of Publication: France NLM ID: 101701089 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2468-7855 (Electronic) Linking ISSN: 24687855 NLM ISO Abbreviation: J Stomatol Oral Maxillofac Surg Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Issy les Moulineaux Cedex : Elsevier Masson SAS, [2017]-
مواضيع طبية MeSH: Tongue Neoplasms*/pathology , Tongue Neoplasms*/therapy , Tongue Neoplasms*/surgery , Tongue Neoplasms*/diagnosis , Fluorodeoxyglucose F18* , Positron Emission Tomography Computed Tomography*/methods , Neoplasm Recurrence, Local*/diagnosis , Salvage Therapy* , Carcinoma, Squamous Cell*/diagnosis , Carcinoma, Squamous Cell*/therapy , Carcinoma, Squamous Cell*/pathology , Carcinoma, Squamous Cell*/surgery , Radiopharmaceuticals*, Humans ; Male ; Female ; Middle Aged ; Aged ; Adult ; Treatment Outcome ; Combined Modality Therapy ; Aged, 80 and over
مستخلص: The purpose of this study was to evaluate the utility of ¹⁸F-fluorodeoxyglucose positron emission tomography/computed tomography (FPCT) parameters for detecting recurrent disease and the outcomes of salvage surgery in patients with locally advanced oral tongue squamous cell carcinoma (TSCC) after multimodal treatment. In total, 69 patients with locally advanced TSCC were treated with multimodal therapy. All patients underwent whole-body FPCT scans 4-10 months after the initial surgery. The analysis included FPCT parameters, such as maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), and total lesion glycolysis (TLG). Histological examination was used as the reference standard. Patients with recurrent TSCC underwent salvage surgery or surgery plus systemic treatment. This study included 69 patients: 36 in the recurrent TSCC group and 33 in the non-recurrent TSCC group. The SUVmax, MTV, and TLG in the recurrent TSCC group were 11.3 ± 3.6, 28.3 ± 15.6 cm 3 , and 113.2 ± 46.8 g, respectively; these values were 5.9 ± 3.6, 5.1 ± 2.2 cm 3 , and 13.4 ± 4.8 g, in the non-recurrent TSCC group respectively. The two groups had significant differences in terms of SUVmax, MTV, and TLG. In the recurrent TSCC group, 91.6 % of patients presented with local, locoregional, and regional disease and underwent salvage surgery plus systemic therapy, whereas 8.4 % had locoregional recurrence with distant metastases alone and underwent surgery plus systemic therapy. The patients were followed up for 12-60 months; 19 and 20 patients in the recurrent and non-recurrent TSCC groups showed no evidence of disease, whereas 11 and 8 were alive with the disease. Local recurrence or distant metastases led to the deaths of six patients in the recurrent TSCC group and five in the non-recurrent TSCC group. No significant differences in survival were observed between the two groups. FPCT parameters can detect the recurrence of locally advanced TSCC after multimodal treatment. Early salvage surgery can improve the treatment outcomes for recurrent TSCC.
Competing Interests: Declaration of Competing Interest We have no financial interest in the products presented in this work.
(Copyright © 2023 Elsevier Masson SAS. All rights reserved.)
فهرسة مساهمة: Keywords: Flap; Fluorodeoxyglucose positron emission tomography/computed tomography; Oral cavity; Prognosis; Reconstruction; Recurrent; Squamous cell carcinoma; Tongue; salvage surgery; ¹⁸F-FDG-PET/CT
المشرفين على المادة: 0Z5B2CJX4D (Fluorodeoxyglucose F18)
0 (Radiopharmaceuticals)
تواريخ الأحداث: Date Created: 20231103 Date Completed: 20240430 Latest Revision: 20240430
رمز التحديث: 20240501
DOI: 10.1016/j.jormas.2023.101673
PMID: 37923135
قاعدة البيانات: MEDLINE
الوصف
تدمد:2468-7855
DOI:10.1016/j.jormas.2023.101673