دورية أكاديمية
Validation of a Multiscale Computational Model Using a Mock Circulatory Loop to Simulate Cardiogenic Shock.
| العنوان: | Validation of a Multiscale Computational Model Using a Mock Circulatory Loop to Simulate Cardiogenic Shock. |
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| المؤلفون: | Contarino C; From the Research and Development, Computational Life Inc., Wilmington, Delaware., Chifari F; From the Research and Development, Computational Life Inc., Wilmington, Delaware., D'Souza GA; Division of Applied Mechanics, Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, US Food and Drug Administration, Silver Spring, Maryland., Herbertson LH; Division of Applied Mechanics, Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, US Food and Drug Administration, Silver Spring, Maryland. |
| المصدر: | ASAIO journal (American Society for Artificial Internal Organs : 1992) [ASAIO J] 2023 Dec 01; Vol. 69 (12), pp. e502-e512. Date of Electronic Publication: 2023 Nov 03. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 9204109 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-943X (Electronic) Linking ISSN: 10582916 NLM ISO Abbreviation: ASAIO J Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Hagerstown, MD : Lippincott Williams & Wilkins Original Publication: Philadelphia, PA : Published for the Society by J.B. Lippincott Co., c1992- |
| مواضيع طبية MeSH: | Shock, Cardiogenic* , Heart-Assist Devices*, Humans ; Hemodynamics ; Heart Ventricles ; Computer Simulation |
| مستخلص: | The objectives of this study are to characterize the hemodynamics of cardiogenic shock (CS) through a computational model validated using a mock circulatory loop (MCL) and to perform sensitivity analysis and uncertainty propagation studies after the American Society of Mechanical Engineers (ASME) Validation and Verification (V&V) guidelines. The uncertainties in cardiac cycle time ( ), total resistance ( ), and total volume ( ) were quantified in the MCL and propagated in the computational model. Both models were used to quantify the pressure in the left atrium, aorta (Ao), and left ventricle (LV), along with the flow through the aortic valve, reaching a good agreement. The results suggest that 1) is the main source of uncertainty in the variables under study, 2) showed its greatest impact on the uncertainty of Ao hemodynamics, and 3) mostly affected the uncertainty of LV pressure and Ao flow at the late-systolic phase. Comparison of uncertainty levels in the computational and experimental results was used to infer the presence of additional contributing factors that were not captured and propagated during a first analysis. Future work will expand upon this study to analyze the impact of mechanical circulatory support devices, such as ventricular assist devices, under CS conditions. Competing Interests: Disclosure: The authors have no conflicts of interest to report. |
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| تواريخ الأحداث: | Date Created: 20231103 Date Completed: 20231204 Latest Revision: 20231222 |
| رمز التحديث: | 20231222 |
| DOI: | 10.1097/MAT.0000000000002062 |
| PMID: | 37923315 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1538-943X |
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| DOI: | 10.1097/MAT.0000000000002062 |