دورية أكاديمية
Predictive value of coronary artery computed tomography-derived fractional flow reserve for cardiovascular events in patients with coronary artery disease.
| العنوان: | Predictive value of coronary artery computed tomography-derived fractional flow reserve for cardiovascular events in patients with coronary artery disease. |
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| عنوان ترانسليتريتد: | Prädiktiver Wert der mittels Koronararterien-Computertomographie abgeleiteten fraktionellen Flussreserve für kardiovaskuläre Ereignisse bei Patienten mit koronarer Herzkrankheit. |
| المؤلفون: | Han H; Department of Cardiovascular Medicine, 903 RD Hospital of the Chinese People's Liberation Army, 310000, Hangzhou, Zhejiang, China.; Zhejiang University School of Medicine, 310000, Hangzhou, Zhejiang, China., Liu M; Department of Cardiovascular Medicine, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, 310000, Hangzhou, Zhejiang, China., Yu Y; Department of Cardiovascular Medicine, 903 RD Hospital of the Chinese People's Liberation Army, 310000, Hangzhou, Zhejiang, China., Chen Y; Department of Cardiovascular Medicine, 903 RD Hospital of the Chinese People's Liberation Army, 310000, Hangzhou, Zhejiang, China., Xu Y; Department of Cardiovascular Medicine, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, 310000, Hangzhou, Zhejiang, China. |
| المصدر: | Herz [Herz] 2024 Aug; Vol. 49 (4), pp. 296-301. Date of Electronic Publication: 2023 Nov 03. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Urban Und Vogel Country of Publication: Germany NLM ID: 7801231 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1615-6692 (Electronic) Linking ISSN: 03409937 NLM ISO Abbreviation: Herz Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Munchen : Urban Und Vogel Original Publication: München, Urban & Schwarzenberg. |
| مواضيع طبية MeSH: | Fractional Flow Reserve, Myocardial*/physiology , Coronary Artery Disease*/complications , Coronary Artery Disease*/diagnostic imaging , Coronary Artery Disease*/physiopathology , Coronary Artery Disease*/mortality , Predictive Value of Tests*, Humans ; Male ; Female ; Middle Aged ; Retrospective Studies ; Aged ; Coronary Angiography ; Computed Tomography Angiography ; Prognosis ; Tomography, X-Ray Computed |
| مستخلص: | Background: Coronary computed tomography-derived fractional flow reserve (FFR-CT) assesses whether coronary artery lesions will result in myocardial ischemia. This study aimed to evaluate the predictive value of FFR-CT for cardiovascular events in patients with coronary artery disease (CAD). Methods: Data were collected retrospectively from patients with CAD who underwent FFR-CT at our hospital from January 2020 to February 2022 (1-year average follow-up). Patients were divided into ischemic (FFR-CT ≤ 0.80) and non-ischemic (FFR-CT > 0.80) groups. The incidence of endpoint events (cardiac death, acute myocardial infarction, unplanned revascularization, unstable angina, and stable angina) was calculated. The FFR-CT value was correlated with endpoint events using Cox regression models and Kaplan-Meier survival curves. Results: We recruited 134 patients (93 [69.4%] and 41 [30.6%] patients in the ischemic and non-ischemic groups, respectively). The ischemic group had a higher proportion of men, patients with type 2 diabetes and hypertension, and patients taking antiplatelet drugs and β‑blockers than did the non-ischemic group (all p < 0.05), whereas other parameters were comparable. Multivariate Cox regression analysis revealed no significant differences in cardiac death, acute myocardial infarction, unplanned revascularization, and unstable angina between the groups. The incidence of stable angina events (hazard ratio: 3.092, 95% confidence interval: 1.362-7.022, p = 0.007) was significantly higher in the ischemic group. Kaplan-Meier survival analysis revealed a significant difference in event-free survival for stable angina between the groups (p = 0.002). Conclusion: In patients with CAD, FFR-CT showed an independent predictive value for stable angina within 1 year of examination. (© 2023. The Author(s), under exclusive licence to Springer Medizin Verlag GmbH, ein Teil von Springer Nature.) |
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| معلومات مُعتمدة: | OO20200121 the Construction Fund of Key Medical Disciplines of Hangzhou |
| فهرسة مساهمة: | Keywords: Atherosclerotic heart disease; Cardiovascular events; Coronary arteriosclerosis; Coronary computed tomography-derived fractional flow reserve; Predictive value Local Abstract: [Publisher, German] HINTERGRUND: Mit der durch koronare Computertomographie bestimmten fraktionellen Flussreserve (FFR-CT) lässt sich beurteilen, ob Läsionen der Koronararterien zu einer Myokardischämie führen werden. Ziel der vorliegenden Studie war es, den prädiktiven Wert der FFR-CT für kardiovaskuläre Ereignisse bei Patienten mit koronarer Herzkrankheit (KHK) zu untersuchen. [Publisher, German] Dazu wurden retrospektiv Daten von Patienten mit KHK erfasst, bei denen in der Klinik der Autoren zwischen Januar 2020 und Februar 2022 (Ein-Jahres-Follow-up) eine FFR-CT durchgeführt wurde. Die Patienten wurden in eine Ischämiegruppe (FFR-CT ≤ 0,80) und eine Gruppe ohne Ischämie (FFR-CT > 0,80) eingeteilt. Die Inzidenz der Endpunktereignisse (Herztod, akuter Herzinfarkt, ungeplante Revaskularisierung, instabile Angina und stabile Angina) wurde berechnet. Der FFR-CT-Wert wurde anhand von Cox-Regressions-Modellen und Kaplan-Meier-Überlebenskurven mit den Endpunktereignissen korreliert. [Publisher, German] Für die Studie wurden 134 Patienten rekrutiert (93 [69,4%] in der Ischämiegruppe bzw. 41 [30,6%] Patienten in der Gruppe ohne Ischämie). In der Ischämiegruppe gab es einen höheren Anteil an Männern, Patienten mit Typ-2-Diabetes und Hypertonie sowie Patienten, die Thrombozytenaggregationshemmer und β‑Blocker einnahmen, als in der Gruppe ohne Ischämie (alle p < 0,05), während andere Parameter vergleichbar waren. Die multivariate Cox-Regressions-Analyse ergab keine signifikanten Unterschiede in Bezug auf Herztod, akuten Herzinfarkt, ungeplante Revaskularisierung und instabile Angina zwischen den Gruppen. In der Ischämiegruppe war die Inzidenz von Ereignissen mit stabiler Angina (Hazard Ratio: 3,092; 95%-Konfidenzintervall: 1,362–7,022; p = 0,007) signifikant höher. Die Kaplan-Meier-Überlebensanalyse ergab einen signifikanten Unterschied zwischen den Gruppen für das ereignisfreie Überleben in Bezug auf stabile Angina (p = 0,002). [Publisher, German] Bei Patienten mit KHK wurde für die FFR-CT ein unabhängiger prädiktiver Wert in Bezug auf stabile Angina innerhalb eines Jahres nach der Untersuchung nachgewiesen. |
| تواريخ الأحداث: | Date Created: 20231104 Date Completed: 20240729 Latest Revision: 20240729 |
| رمز التحديث: | 20240730 |
| DOI: | 10.1007/s00059-023-05220-3 |
| PMID: | 37923966 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1615-6692 |
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| DOI: | 10.1007/s00059-023-05220-3 |