دورية أكاديمية
Cancer mortality after kidney transplantation: A multicenter cohort study in Italy.
| العنوان: | Cancer mortality after kidney transplantation: A multicenter cohort study in Italy. |
|---|---|
| المؤلفون: | Taborelli M; Unit of Cancer Epidemiology, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, Aviano, Italy., Serraino D; Unit of Cancer Epidemiology, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, Aviano, Italy., Cimaglia C; Department of Epidemiology and Pre-Clinical Research, National Institute for Infectious Diseases 'L. Spallanzani' IRCCS, Rome, Italy., Furian L; Unit of Kidney and Pancreas Transplantation, Department of Surgical, Oncological and Gastroenterological Sciences, University of Padova, Padova, Italy., Biancone L; Division of Nephrology Dialysis and Transplantation, Renal Transplantation Center 'A. Vercellone,' Città della Salute e della Scienza University Hospital, Turin, Italy., Busnach G; Independent Researcher, Milano, Italy., Bossini N; Unit of Nephrology, ASST Spedali Civili di Brescia, Brescia, Italy., Citterio F; Department of Surgery, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy., Veroux M; Organ Transplantation Unit, Department of Medical and Surgical Sciences and Advanced Technologies, University Hospital of Catania, Catania, Italy., Iaria M; Department of General and Specialized Surgery, Division of General Surgery, Transplant Surgery Unit, Parma University Hospital, Parma, Italy., Argiolas D; Renal Transplant Unit, Azienda Ospedaliera Brotzu, Cagliari, Italy., Todeschini P; Department of Experimental Diagnostic and Specialty Medicine (DIMEC), Nephrology, Dialysis and Renal Transplant Unit, IRCCS S. Orsola Hospital, University of Bologna, Bologna, Italy., Manzia TM; UOC Transplant Unit, Department of Surgery, Tor Vergata University, Rome, Italy., Pisani F; General and Transplant Surgery Department, University of L'Aquila, L'Aquila, Italy., Cantaluppi V; Nephrology and Kidney Transplantation Unit, Department of Translational Medicine, University of Piemonte Orientale (UPO), 'Maggiore della Carità' University Hospital, Novara, Italy., Simone S; Nephrology, Dialysis and Transplantation Unit, Department of Emergency and Organ Transplantation, University of Bari, Bari, Italy., Mangino M; Nephrology, Dialysis, Transplantation Unit, Ca' Foncello Hospital, Treviso, Italy., Campise M; Unit of Nephrology, Dialysis, and Renal Transplantation, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy., Ambrosini A; Renal Transplant Unit, Azienda Ospedaliera Ospedale di Circolo e Fondazione Macchi, Varese, Italy., Caputo F; Nephrology Dialysis and Renal Transplant Department, Civico and Di Cristina Hospital, Palermo, Italy., Piselli P; Department of Epidemiology and Pre-Clinical Research, National Institute for Infectious Diseases 'L. Spallanzani' IRCCS, Rome, Italy. |
| مؤلفون مشاركون: | Italian Transplant and Cancer Cohort Study |
| المصدر: | International journal of cancer [Int J Cancer] 2024 Mar 01; Vol. 154 (5), pp. 842-851. Date of Electronic Publication: 2023 Nov 04. |
| نوع المنشور: | Multicenter Study; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-Liss Country of Publication: United States NLM ID: 0042124 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-0215 (Electronic) Linking ISSN: 00207136 NLM ISO Abbreviation: Int J Cancer Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 1995- : New York, NY : Wiley-Liss Original Publication: 1966-1984 : Genève : International Union Against Cancer |
| مواضيع طبية MeSH: | Kidney Transplantation*/adverse effects , Neoplasms* , Lymphoma*/epidemiology , Kidney Neoplasms*/complications, Humans ; Cohort Studies ; Cause of Death ; Italy/epidemiology |
| مستخلص: | Kidney transplant (KT) recipients are known to be at risk of developing several cancer types; however, cancer mortality in this population is underinvestigated. Our study aimed to assess the risk of cancer death among Italian KT recipients compared to the corresponding general population. A cohort study was conducted among 7373 individuals who underwent KT between 2003 and 2020 in 17 Italian centers. Date and cause of death were retrieved until 31 December 2020. Indirect standardization was used to estimate standardized mortality ratios (SMRs) and corresponding 95% confidence intervals (CIs). Cancer was the most common cause of death among the 7373 KT recipients, constituting 32.4% of all deaths. A 1.8-fold excess mortality (95% CI: 1.59-2.09) was observed for all cancers combined. Lymphomas (SMR = 6.17, 95% CI: 3.81-9.25), kidney cancer (SMR = 5.44, 95% CI: 2.97-8.88) and skin melanoma (SMR = 3.19, 95% CI: 1.03-6.98) showed the highest excess death risks. In addition, SMRs were increased about 1.6 to 3.0 times for cancers of lung, breast, bladder and other hematopoietic and lymphoid tissues. As compared to the general population, relative cancer mortality risk remained significantly elevated in all age groups though it decreased with increasing age. A linear temporal increase in SMR over time was documented for all cancers combined (P < .01). Our study documented significantly higher risks of cancer death in KT recipients than in the corresponding general population. Such results support further investigation into the prevention and early detection of cancer in KT recipients. (© 2023 The Authors. International Journal of Cancer published by John Wiley & Sons Ltd on behalf of UICC.) |
| References: | Francis A, Au E, Lim WH, Wong G. Post-transplant cancer: An epidemiological evaluation. J Onco-Nephrol. 2020;4(3):145-152. Chapman JR, Webster AC, Wong G. Cancer in the transplant recipient. Cold Spring Harb Perspect Med. 2013;3(7):a015677. Pilmore H, Dent H, Chang S, McDonald SP, Chadban SJ. Reduction in cardiovascular death after kidney transplantation. Transplantation. 2010;89(7):851-857. Wong G, Chapman JR, Craig JC. Death from cancer: a sobering truth for patients with kidney transplants. Kidney Int. 2014;85(6):1262-1264. Taborelli M, Piselli P, Ettorre GM, et al. Survival after the diagnosis of de novo malignancy in liver transplant recipients. Int J Cancer. 2019;144(2):232-239. Taborelli M, Serraino D, Cimaglia C, et al. The impact of cancer on the risk of death with a functioning graft of Italian kidney transplant recipients. Am J Transplant. 2022;22:588-598. Lim WH, Badve SV, Wong G. Long-term allograft and patient outcomes of kidney transplant recipients with and without incident cancer - a population cohort study. Oncotarget. 2017;8(44):77771-77782. Piselli P, Serraino D, Cimaglia C, et al. Variation in post-transplant cancer incidence among Italian kidney transplant recipients over a 25-year period. Cancer. 2023;15(4):1347. Friman TK, Jäämaa-Holmberg S, Åberg F, et al. Cancer risk and mortality after solid organ transplantation: a population-based 30-year cohort study in Finland. Int J Cancer. 2022;150(11):1779-1791. Acuna SA. Etiology of increased cancer incidence after solid organ transplantation. Transplant Rev. 2018;32(4):218-224. Engels EA. Cancer in solid organ transplant recipients: there is still much to learn and do. Am J Transplant. 2017;17(8):1967-1969. Au E, Wong G, Chapman JR. Cancer in kidney transplant recipients. Nat Rev Nephrol. 2018;14(8):508-520. Acuna SA, Fernandes KA, Daly C, et al. Cancer mortality among recipients of solid-organ transplantation in Ontario, Canada. JAMA Oncol. 2016;2(4):463-469. Rosales BM, De La Mata N, Vajdic CM, Kelly PJ, Wyburn K, Webster AC. Cancer mortality in kidney transplant recipients: an Australian and New Zealand population-based cohort study, 1980-2013. Int J Cancer. 2020;146(10):2703-2711. Au EH, Chapman JR, Craig JC, et al. Overall and site-specific cancer mortality in patients on dialysis and after kidney transplant. J Am Soc Nephrol. 2019;30(3):471-480. Tessari G, Maggiore U, Zaza G, et al. Mortality from cancer is not increased in elderly kidney transplant recipients compared to the general population: a competing risk analysis. J Nephrol. 2020;33(6):1309-1319. Hosmer D, Lemeshow S, May S. Applied Survival Analysis: Regression Modeling of Time-to-Event Data. 2nd ed. Hoboken, NJ: John Wiley & Sons; 2008. Breslow NE, Day NE. Statistical Methods in Cancer Research Vol. I: The Analysis of Case-Controls Studies. International Agency for Research on Cancer: Lyon, France; 1980. ISTAT. Causes of death. http://dati.istat.it/. Accessed July 3, 2023. Farewell VT. Statistical methods for individual-level data in cohort mortality studies of rheumatic diseases. Commun Stat - Theory Methods. 2009;38:3472-3487. Kiberd BA, Rose C, Gill JS. Cancer mortality in kidney transplantation. Am J Transplant. 2009;9(8):1868-1875. Farrugia D, Mahboob S, Cheshire J, et al. Malignancy-related mortality following kidney transplantation is common. Kidney Int. 2014;85(6):1395-1403. Engels EA, Pfeiffer RM, Fraumeni JF, et al. Spectrum of cancer risk among US solid organ transplant recipients. JAMA. 2011;306(17):1891-1901. Young K, Jiang H, Marquez M, et al. Retrospective study of the incidence and outcomes from lung cancer in solid organ transplant recipients. Lung Cancer. 2020;147:214-220. Chen LN, Spivack J, Cao T, et al. Characteristics and outcomes of lung cancer in solid organ transplant recipients. Lung Cancer. 2020;146:297-302. Cheung CY, Lam MF, Chu KH, et al. Malignancies after kidney transplantation: Hong Kong renal registry. Am J Transplant. 2012;12(11):3039-3046. Webster AC, Wong G, McDonald SP. ANZDATA Registry 32nd Annual Report. Adelaide: The Australia and New Zealand Dialysis and Transplant Registry; 2009. Wong G, Au E, Badve SV, Lim WH. Breast cancer and transplantation. Am J Transplant. 2017;17(9):2243-2253. Global Burden of Disease 2019 Cancer Collaboration. Cancer incidence, mortality, years of life lost, years lived with disability, and disability-adjusted life years for 29 cancer groups from 2010 to 2019: a systematic analysis for the global burden of disease study 2019. JAMA Oncol. 2022;8(3):420. Blosser CD, Haber G, Engels EA. Changes in cancer incidence and outcomes among kidney transplant recipients in the United States over a thirty-year period. Kidney Int. 2021;99(6):1430-1438. Benoni H, Eloranta S, Ekbom A, Wilczek H, Smedby KE. Survival among solid organ transplant recipients diagnosed with cancer compared to nontransplanted cancer patients-a nationwide study. Int J Cancer. 2020;146(3):682-691. Turshudzhyan A. Post-renal transplant malignancies: opportunities for prevention and early screening. Cancer Treat Res Commun. 2021;26:100283. Reshef R, Vardhanabhuti S, Luskin M, et al. Reduction of immunosuppression as initial therapy for post-transplantation lymphoproliferative disorder. Am J Transplant. 2011;11(2):336-347. Dharia A, Boulet J, Sridhar VS, Kitchlu A. Cancer screening in solid organ transplant recipients: a focus on screening liver, lung, and kidney recipients for cancers related to the transplanted organ. Transplantation. 2022;106(1):e64-e65. |
| معلومات مُعتمدة: | CRO Aviano "5x1000 (Redditi 2018)"; 19112 Italian Association for Research on Cancer; Italian Ministry of Health |
| فهرسة مساهمة: | Investigator: L Fratino; F Toffolutti; A Agresta; E Girardi; A Nappo; E Boccalon; C Di Bella; E Nuzzolese; P Rigotti; A Lavacca; V Colombo; M Querques; S Possenti; S Sandrini; L Panicali; C Valentini; E Cremaschi; U Maggiore; A Palmisano; C Pellegrino; C Puliatti; G Grandaliano; MP Salerno; E Schifano; P Silvestri; G Spagnoletti; CM Alfieri; G Castellano; E Favi; M Ferraresso; S Iesari; D Corona; C Distefano; P Veroux; F Blasi; F Romano; L Toti; C Cornella; G Merlotti; M Quaglia; MC Maresca; L Gesualdo; E Carta; GB Piredda; M De Cicco; G Ietto; D Iovino; F Perna; L Lancione; A Panarese; A Amato; B Buscemi Keywords: cancer mortality; cohort study; immunosuppression; kidney transplant; virus-related malignancy |
| تواريخ الأحداث: | Date Created: 20231104 Date Completed: 20240105 Latest Revision: 20240105 |
| رمز التحديث: | 20240105 |
| DOI: | 10.1002/ijc.34787 |
| PMID: | 37924271 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1097-0215 |
|---|---|
| DOI: | 10.1002/ijc.34787 |