دورية أكاديمية
أعرض في EDS

Small-molecule tools for YEATS domain proteins.

التفاصيل البيبلوغرافية
العنوان: Small-molecule tools for YEATS domain proteins.
المؤلفون: Erb MA; Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA. Electronic address: michaelerb@scripps.edu.
المصدر: Current opinion in chemical biology [Curr Opin Chem Biol] 2023 Dec; Vol. 77, pp. 102404. Date of Electronic Publication: 2023 Nov 03.
نوع المنشور: Journal Article; Review; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: England NLM ID: 9811312 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0402 (Electronic) Linking ISSN: 13675931 NLM ISO Abbreviation: Curr Opin Chem Biol Subsets: MEDLINE
أسماء مطبوعة: Publication: London : Elsevier
Original Publication: London : Current Biology Ltd., c1997-
مواضيع طبية MeSH: Histones*/chemistry , Chromatin*, Humans ; Protein Domains
مستخلص: Chromatin reader domains are protein folds that bind to post-translational modifications of histones and other chromatin-associated proteins. Compared to other families of reader domains, the discovery that YEATS domains bind to acylated lysines is relatively recent. Four human proteins harbor a YEATS domain, and each is present in protein complexes that regulate chromatin and transcription (ENL, AF9, YEATS2, and YEATS4). Without chemical tools to enable temporally resolved perturbations, it is often unclear how reader domains contribute to protein function. Here, we will discuss recent progress in developing small-molecule tools for YEATS domains and highlight their usefulness for making biological discoveries.
Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests:Michael Erb has patent #WO2021021904A1 issued to The Scripps Research Institute.
(Copyright © 2023 Elsevier Ltd. All rights reserved.)
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معلومات مُعتمدة: DP5 OD026380 United States OD NIH HHS
المشرفين على المادة: 0 (Histones)
0 (Chromatin)
تواريخ الأحداث: Date Created: 20231104 Date Completed: 20231201 Latest Revision: 20240529
رمز التحديث: 20240530
مُعرف محوري في PubMed: PMC10842393
DOI: 10.1016/j.cbpa.2023.102404
PMID: 37924571
قاعدة البيانات: MEDLINE
الوصف
تدمد:1879-0402
DOI:10.1016/j.cbpa.2023.102404