دورية أكاديمية
The Post-conditioning Acute Strength Exercise Facilitates Contextual Fear Memory Consolidation Via Hippocampal N-methyl-D-aspartate-receptors.
| العنوان: | The Post-conditioning Acute Strength Exercise Facilitates Contextual Fear Memory Consolidation Via Hippocampal N-methyl-D-aspartate-receptors. |
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| المؤلفون: | Leite AKO; Postgraduate Program in Translational Neuroscience, PGNET, National Institute of Translational Neuroscience, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil., Farias CP; Postgraduate Program in Translational Neuroscience, PGNET, National Institute of Translational Neuroscience, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil., Schmidt BE; Postgraduate Program in Translational Neuroscience, PGNET, National Institute of Translational Neuroscience, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil., Teixeira L; Neuroprotection and Neurometabolic Diseases Laboratory (Wyse's Lab), Graduate Program in Biological Sciences: Biochemistry, Department of Biochemistry, ICBS, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil., Rieder AS; Neuroprotection and Neurometabolic Diseases Laboratory (Wyse's Lab), Graduate Program in Biological Sciences: Biochemistry, Department of Biochemistry, ICBS, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil., Furini CRG; Laboratory of Cognition and Memory Neurobiology, Brain Institute, Pontificia Universidade Católica do Rio Grande do Sul (PUCRS), Av. Ipiranga, 6690 - 3rd Floor, 90610-000 Porto Alegre, RS, Brazil., Wyse ATS; Postgraduate Program in Translational Neuroscience, PGNET, National Institute of Translational Neuroscience, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil; Neuroprotection and Neurometabolic Diseases Laboratory (Wyse's Lab), Graduate Program in Biological Sciences: Biochemistry, Department of Biochemistry, ICBS, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil. Electronic address: wyse@ufrgs.br. |
| المصدر: | Neuroscience [Neuroscience] 2023 Dec 15; Vol. 535, pp. 88-98. Date of Electronic Publication: 2023 Nov 02. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Country of Publication: United States NLM ID: 7605074 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7544 (Electronic) Linking ISSN: 03064522 NLM ISO Abbreviation: Neuroscience Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: [New York?] : Elsevier Science Original Publication: Oxford, Elmsford, N. Y., Pergamon Press |
| مواضيع طبية MeSH: | N-Methylaspartate*/metabolism , Memory Consolidation*/physiology, Rats ; Animals ; Male ; Rats, Wistar ; Dizocilpine Maleate/pharmacology ; Synapsins/metabolism ; Brain-Derived Neurotrophic Factor/metabolism ; Hippocampus/metabolism ; Fear/physiology ; Receptors, N-Methyl-D-Aspartate/metabolism |
| مستخلص: | The benefits of aerobic exercises for memory are known, but studies of strength training on memory consolidation are still scarce. Exercise stimulates the release of metabolites and myokines that reaching the brain stimulate the activation of NMDA-receptors and associated pathways related to cognition and synaptic plasticity. The aim of the present study was to investigate whether the acute strength exercise could promote the consolidation of a weak memory. We also investigated whether the effects of strength exercise on memory consolidation and on the BDNF and synapsin I levels depends on the activation of NMDA-receptors. Male Wistar rats were submitted to strength exercise session after a weak training in contextual fear conditioning paradigm to investigate the induction of memory consolidation. To investigate the participation of NMDA-receptors animals were submitted to contextual fear training and strength exercise and infused with MK801 or saline immediately after exercise. To investigate the participation of NMDA-receptors in BDNF and synapsin I levels the animals were submitted to acute strength exercise and infused with MK801 or saline immediately after exercise (in absence of behavior experiment). Results showed that exercise induced the consolidation of a weak memory and this effect was dependent on the activation of NMDA-receptors. The hippocampal overexpression of BDNF and Synapsin I through exercise where NMDA-receptors dependent. Our findings showed that strength exercise strengthened fear memory consolidation and modulates the overexpression of BDNF and synapsin I through the activation of NMDA-receptors dependent signaling pathways. (Copyright © 2023 IBRO. Published by Elsevier Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: consolidation processes; fear memory; hippocampus; strength training |
| المشرفين على المادة: | 6384-92-5 (N-Methylaspartate) 6LR8C1B66Q (Dizocilpine Maleate) 0 (Synapsins) 0 (Brain-Derived Neurotrophic Factor) 0 (Receptors, N-Methyl-D-Aspartate) |
| تواريخ الأحداث: | Date Created: 20231104 Date Completed: 20231216 Latest Revision: 20231216 |
| رمز التحديث: | 20231217 |
| DOI: | 10.1016/j.neuroscience.2023.10.016 |
| PMID: | 37925051 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1873-7544 |
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| DOI: | 10.1016/j.neuroscience.2023.10.016 |