دورية أكاديمية
أعرض في EDS

Evolutionary immuno-genetics of endoplasmic reticulum aminopeptidase II (ERAP2).

التفاصيل البيبلوغرافية
العنوان: Evolutionary immuno-genetics of endoplasmic reticulum aminopeptidase II (ERAP2).
المؤلفون: Raja A; Department of Ophthalmology, Center for Translational Immunology, University Medical Center Utrecht, University of Utrecht, Utrecht, The Netherlands., Kuiper JJW; Department of Ophthalmology, Center for Translational Immunology, University Medical Center Utrecht, University of Utrecht, Utrecht, The Netherlands. j.j.w.kuiper@umcutrecht.nl.
المصدر: Genes and immunity [Genes Immun] 2023 Dec; Vol. 24 (6), pp. 295-302. Date of Electronic Publication: 2023 Nov 04.
نوع المنشور: Journal Article; Review; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 100953417 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5470 (Electronic) Linking ISSN: 14664879 NLM ISO Abbreviation: Genes Immun Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Houndmills, Basingstoke, Hampshire, UK : Nature Pub. Group,
مواضيع طبية MeSH: Aminopeptidases*/genetics , Aminopeptidases*/immunology , Endoplasmic Reticulum*/enzymology , Evolution, Molecular* , Adaptive Immunity*/genetics, Humans ; Autoimmune Diseases/genetics ; Autoimmune Diseases/immunology ; Haplotypes ; Minor Histocompatibility Antigens/genetics
مستخلص: Endoplasmic reticulum aminopeptidase 2 (ERAP2) is a proteolytic enzyme involved in adaptive immunity. The ERAP2 gene is highly polymorphic and encodes haplotypes that confer resistance against lethal infectious diseases, but also increase the risk for autoimmune disorders. Identifying how ERAP2 influences susceptibility to these traits requires an understanding of the selective pressures that shaped and maintained allelic variation throughout human evolution. Our review discusses the genetic regulation of haplotypes and diversity in naturally occurring ERAP2 allotypes in the global population. We outline how these ERAP2 haplotypes evolved during human history and highlight the presence of Neanderthal DNA sequences in ERAP2 of modern humans. Recent evidence suggests that human adaptation during the last ~10,000 years and historic pandemics left a significant mark on the ERAP2 gene that determines susceptibility to infectious and inflammatory diseases today.
(© 2023. The Author(s).)
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معلومات مُعتمدة: 954992 EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 Marie Skłodowska-Curie Actions (H2020 Excellent Science - Marie Skłodowska-Curie Actions)
المشرفين على المادة: EC 3.4.11.- (Aminopeptidases)
EC 3.4.11.- (ERAP2 protein, human)
0 (Minor Histocompatibility Antigens)
تواريخ الأحداث: Date Created: 20231105 Date Completed: 20240112 Latest Revision: 20240625
رمز التحديث: 20240626
مُعرف محوري في PubMed: PMC10721543
DOI: 10.1038/s41435-023-00225-8
PMID: 37925533
قاعدة البيانات: MEDLINE
الوصف
تدمد:1476-5470
DOI:10.1038/s41435-023-00225-8