دورية أكاديمية
Chlordecone determination in serum by LC-MS/MS and the importance of low limit of detection.
| العنوان: | Chlordecone determination in serum by LC-MS/MS and the importance of low limit of detection. |
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| المؤلفون: | El Balkhi S; Department of Pharmacology and Toxicology, Limoges University Hospital, France. Electronic address: souleiman.elbalkhi@chu-limoges.fr., Saint-Marcoux F; Department of Pharmacology and Toxicology, Limoges University Hospital, France; Department of Toxicology, Faculty of Pharmacy, Limoges, France. Electronic address: franck.saint-marcoux@unilim.fr. |
| المصدر: | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences [J Chromatogr B Analyt Technol Biomed Life Sci] 2023 Nov 15; Vol. 1230, pp. 123915. Date of Electronic Publication: 2023 Oct 29. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101139554 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-376X (Electronic) Linking ISSN: 15700232 NLM ISO Abbreviation: J Chromatogr B Analyt Technol Biomed Life Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam ; New York : Elsevier, c2002- |
| مواضيع طبية MeSH: | Chlordecone*, Male ; Humans ; Tandem Mass Spectrometry ; Chromatography, Liquid ; Limit of Detection ; Gas Chromatography-Mass Spectrometry |
| مستخلص: | Chlordecone is an organochlorine insecticide that has been used intensively from 1973 to 1993 in the French West Indies banana fields to control root borers. This use has resulted in persistent pollution of soils and waters, and people have been and are still exposed mainly through food. Epidemiological studies showed that this exposure is associated with health disorders, including prostate cancer, prematurity, cognitive or motor development. The measurement of chlordecone in serum is considered as the best surrogate, though no clear and definitive cut-off value has been established. This renders necessary the development of analytical methods with the lowest limit of detection as possible. While most published methods have utilized GC-MS or GC-MS/MS, in the present study we report an LC-MS/MS method based on a simple QuEChERS salts extraction. The whole procedure was validated according to ISO 15189 requirements and reached LOD and LOQ values of 0.007 and 0.02 µg/L, respectively. It was applied to more 10 000 serum samples of French Indies inhabitants. More than a half had a concentration below 0.1 µg/L and more than one third of them exhibiting a concentration below 0.05 µg/L. The capability of this LC-MS/MS method to detect very low concentrations highlights its utility in exploring the health impact of chlordecone. Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2023 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Chlordecone; Insecticide; Liquid chromatography; Mass spectrometry; Pesticide |
| المشرفين على المادة: | RG5XJ88UDF (Chlordecone) |
| تواريخ الأحداث: | Date Created: 20231105 Date Completed: 20231121 Latest Revision: 20231121 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.jchromb.2023.123915 |
| PMID: | 37925903 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1873-376X |
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| DOI: | 10.1016/j.jchromb.2023.123915 |