دورية أكاديمية
Hepcidin Removal during Continuous Renal Replacement Therapy.
| العنوان: | Hepcidin Removal during Continuous Renal Replacement Therapy. |
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| المؤلفون: | Colbert JF; Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado, USA, james.colbert@cuanschutz.edu.; Rocky Mountain Regional Veterans Affairs Medical Center, Aurora, Colorado, USA, james.colbert@cuanschutz.edu., Griffin BR; Department of Medicine, University of Iowa School of Medicine, Iowa City, Iowa, USA., Rolloff K; Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado, USA., Erzen CL; Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado, USA., Haeger SM; Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado, USA., Altmann C; Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado, USA., Okamura K; Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado, USA., Campbell R; Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado, USA., Teitelbaum I; Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado, USA., Faubel S; Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado, USA. |
| المصدر: | Blood purification [Blood Purif] 2024; Vol. 53 (1), pp. 23-29. Date of Electronic Publication: 2023 Nov 03. |
| نوع المنشور: | Observational Study; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: S. Karger Country of Publication: Switzerland NLM ID: 8402040 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1421-9735 (Electronic) Linking ISSN: 02535068 NLM ISO Abbreviation: Blood Purif Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Basel ; New York : S. Karger, [c1983- |
| مواضيع طبية MeSH: | Continuous Renal Replacement Therapy* , Acute Kidney Injury*, Humans ; Renal Replacement Therapy/methods ; Prospective Studies ; Hepcidins ; Retrospective Studies ; Critical Illness/therapy |
| مستخلص: | Introduction: Patients with acute kidney injury (AKI) or end stage kidney disease (ESKD) may require continuous renal replacement therapy (CRRT) as a supportive intervention. While CRRT is effective at achieving solute control and fluid balance, the indiscriminate nature of this procedure raises the possibility that beneficial substances may similarly be removed. Hepcidin, an antimicrobial peptide with pivotal roles in iron homeostasis and pathogen clearance, has biochemical properties amenable to direct removal via CRRT. We hypothesized that serum hepcidin levels would significantly decrease after initiation of CRRT. Methods: In this prospective, observational trial, we enrolled 13 patients who required CRRT: 11 due to stage 3 AKI, and 2 due to critical illness in the setting of ESKD. Plasma was collected at the time of enrollment, and then plasma and effluent were collected at 10:00 a.m. on the following 3 days. Plasma samples were also collected from healthy controls, and we compared hepcidin concentrations in those with renal disease compared to normal controls, evaluated trends in hepcidin levels over time, and calculated the hepcidin sieving coefficient. Results: Plasma hepcidin levels were significantly higher in patients initiating CRRT than in normal controls (158 ± 60 vs. 17 ± 3 ng/mL respectively, p < 0.001). Hepcidin levels were highest prior to CRRT initiation (158 ± 60 ng/mL), and were significantly lower on day 1 (102 ± 24 ng/mL, p < 0.001) and day 2 (56 ± 14 ng/mL, p < 0.001) before leveling out on day 3 (51 ± 11 ng/mL). The median sieving coefficient was consistent at 0.82-0.83 for each of 3 days. Conclusions: CRRT initiation is associated with significant decreases in plasma hepcidin levels over the first 2 days of treatment regardless of indication for CRRT, or presence of underlying ESKD. Since reduced hepcidin levels are associated with increased mortality and our data implicate CRRT in hepcidin removal, larger clinical studies evaluating relevant clinical outcomes based on hepcidin trends in this population should be pursued. (© 2023 S. Karger AG, Basel.) |
| فهرسة مساهمة: | Keywords: Continuous renal replacement therapy; Hepcidin; Sepsis |
| المشرفين على المادة: | 0 (Hepcidins) |
| تواريخ الأحداث: | Date Created: 20231105 Date Completed: 20240117 Latest Revision: 20240117 |
| رمز التحديث: | 20240117 |
| DOI: | 10.1159/000534297 |
| PMID: | 37926081 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1421-9735 |
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| DOI: | 10.1159/000534297 |