دورية أكاديمية
Injectable thermogel incorporating reactive oxygen species scavenger and nitric oxide donor to accelerate the healing process of diabetic wounds.
| العنوان: | Injectable thermogel incorporating reactive oxygen species scavenger and nitric oxide donor to accelerate the healing process of diabetic wounds. |
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| المؤلفون: | Dang LH; Graduate University of Science and Technology, Vietnam Academy of Science and Technology, HCMC, Viet Nam; Institute of Applied Materials Science, Vietnam Academy of Science and Technology, HCMC, Viet Nam. Electronic address: lehadang0804@gmail.com., Do THT; Faculty of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh City, Viet Nam., Pham TKT; Biotechnology Center of Ho Chi Minh City, Hochiminh City 700000, Viet Nam., Ha PT; Institute of Materials Science, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet Road, Cau Giay District, Hanoi 10000, Viet Nam., Nguyen TP; Faculty of Chemical Technology, Ho Chi Minh City University of Industry and Trade, Ho Chi Minh City 700000, Viet Nam., Dao TP; Institute of Applied Technology and Sustainable Development, Nguyen Tat Thanh University, Ho Chi Minh City 700000, Viet Nam., Tran NQ; Graduate University of Science and Technology, Vietnam Academy of Science and Technology, HCMC, Viet Nam; Institute of Applied Materials Science, Vietnam Academy of Science and Technology, HCMC, Viet Nam. Electronic address: tnquyen@iams.vast.vn. |
| المصدر: | International journal of pharmaceutics [Int J Pharm] 2023 Dec 15; Vol. 648, pp. 123576. Date of Electronic Publication: 2023 Nov 04. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 7804127 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3476 (Electronic) Linking ISSN: 03785173 NLM ISO Abbreviation: Int J Pharm Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam, Elsevier/North-Holland Biomedical Press. |
| مواضيع طبية MeSH: | Nitric Oxide Donors*/pharmacology , Diabetes Mellitus, Experimental*/drug therapy, Animals ; Mice ; Reactive Oxygen Species ; Resveratrol/pharmacology ; Anti-Bacterial Agents ; Arginine ; Fishes ; Hydrogels |
| مستخلص: | The healing of diabetic wounds is challenging due to redox imbalances. Herein, the thermogelling system AR-ACP hydrogel, with encapsulated biosafe nitric oxide (NO) donor L-arginine and resveratrol as an ROS scavenger, is established for sustainable wound therapy in the diabetic state. The innovated AR-ACP hydrogel dressings shows the sol-gel transition at 34 °C, allowing the hydrogel to fully cover wounds. The combination of L-arginine and resveratrol showed a prominent effect on anti-oxidative activity. The elimination of superoxide anions from the activated immune cells/oxidative cells by resveratrol maintained the NO-proangiogenic factors generated from L-arginine. Furthermore, the AR-ACP hydrogel endowed outstanding features such as haemocompatibility, non-skin irradiation as well as antibacterial activity. In the in vivo diabetic mice model, complete epidermal regeneration comparable to undamaged skin was observed with AR-ACP hydrogel. The synergy between L-arginine and resveratrol in the ACP hydrogel facilitated neovascularisation in the early stage, resulting in the higher balance in cellularity growth and collagen deposition in the dermal layer compared to control groups. Taken together, our findings demonstrate that the use of a customised ACP-based hydrogel, with the additional L-arginine and resveratrol, resulted in significant skin regeneration in the diabetic state. Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2023 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Diabetic wounds; L-arginine; ROS scavenger; Resveratrol; Thermogelling system; nitric oxide (NO) donor |
| المشرفين على المادة: | 0 (Reactive Oxygen Species) 0 (Nitric Oxide Donors) Q369O8926L (Resveratrol) 0 (Anti-Bacterial Agents) 94ZLA3W45F (Arginine) 0 (Hydrogels) |
| تواريخ الأحداث: | Date Created: 20231105 Date Completed: 20231205 Latest Revision: 20231205 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.ijpharm.2023.123576 |
| PMID: | 37926176 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1873-3476 |
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| DOI: | 10.1016/j.ijpharm.2023.123576 |