دورية أكاديمية
Two into one does go: Formulation development of a multipurpose combination vaginal ring releasing dapivirine and metronidazole for prevention of HIV infection and treatment of bacterial vaginosis.
| العنوان: | Two into one does go: Formulation development of a multipurpose combination vaginal ring releasing dapivirine and metronidazole for prevention of HIV infection and treatment of bacterial vaginosis. |
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| المؤلفون: | Zhao X; School of Pharmacy, Medical Biology Centre, Queen's University Belfast, Belfast BT9 7BL, UK., Boyd P; School of Pharmacy, Medical Biology Centre, Queen's University Belfast, Belfast BT9 7BL, UK., Bashi YD; School of Pharmacy, Medical Biology Centre, Queen's University Belfast, Belfast BT9 7BL, UK., Murphy DJ; School of Pharmacy, Medical Biology Centre, Queen's University Belfast, Belfast BT9 7BL, UK., McCoy CF; School of Pharmacy, Medical Biology Centre, Queen's University Belfast, Belfast BT9 7BL, UK., Coulter S; School of Pharmacy, Medical Biology Centre, Queen's University Belfast, Belfast BT9 7BL, UK., Laverty G; School of Pharmacy, Medical Biology Centre, Queen's University Belfast, Belfast BT9 7BL, UK., Malcolm RK; School of Pharmacy, Medical Biology Centre, Queen's University Belfast, Belfast BT9 7BL, UK. Electronic address: k.malcolm@qub.ac.uk. |
| المصدر: | International journal of pharmaceutics [Int J Pharm] 2023 Dec 15; Vol. 648, pp. 123572. Date of Electronic Publication: 2023 Nov 04. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 7804127 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3476 (Electronic) Linking ISSN: 03785173 NLM ISO Abbreviation: Int J Pharm Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam, Elsevier/North-Holland Biomedical Press. |
| مواضيع طبية MeSH: | Vaginosis, Bacterial*/drug therapy , Vaginosis, Bacterial*/prevention & control , HIV Infections*/drug therapy , HIV Infections*/prevention & control , Contraceptive Devices, Female*, Female ; Humans ; Metronidazole ; Vagina/microbiology |
| مستخلص: | Bacterial vaginosis (BV) is a common but often asymptomatic dysbiosis of the human vagina characterized by an imbalance in the normal vaginal microbiota due to loss of lactobacilli and an overgrowth of certain anaerobic bacteria. While BV itself is not a sexually transmitted infection, it is associated with an increased risk in women of various sexually acquired infections, including human immunodeficiency virus (HIV) infection. There is, therefore, a strong rationale for pursuing new multipurpose products that seek to treat or prevent BV alongside preventing HIV infection. With the dapivirine-releasing vaginal ring for HIV prevention now approved in several African countries, here we report formulation development of a next-generation ring product that releases both dapivirine (DPV) and the antibiotic drug metronidazole (MET). Following thermal analysis studies to characterize the phase behaviour of DPV-MET mixtures and rheological analysis to assess the cure characteristics of the active silicone elastomer mixes, matrix-type rings were manufactured containing 25 or 200 mg DPV in combination with 100, 250, 500, 1000 or 2000 mg MET. The results for drug content, in vitro release, mechanical testing, and Gardnerella vaginalis time-kill experiments demonstrate the feasibility of incorporating both DPV and MET in a matrix-type ring formulation and indicate that clinically effective release rates may be possible. Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2023 The Author(s). Published by Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Gardnerella vaginalis; HIV prevention; Multipurpose prevention technology (MPT); Sustained release |
| المشرفين على المادة: | 140QMO216E (Metronidazole) TCN4MG2VXS (Dapivirine) |
| تواريخ الأحداث: | Date Created: 20231105 Date Completed: 20231205 Latest Revision: 20231205 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.ijpharm.2023.123572 |
| PMID: | 37926178 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1873-3476 |
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| DOI: | 10.1016/j.ijpharm.2023.123572 |