Toxic, genotoxic, mutagenic, and bioaccumulative effects of metal mixture from settleable particulate matter on American bullfrog tadpoles (Lithobates catesbeianus).

التفاصيل البيبلوغرافية
العنوان:	Toxic, genotoxic, mutagenic, and bioaccumulative effects of metal mixture from settleable particulate matter on American bullfrog tadpoles (Lithobates catesbeianus).
المؤلفون:	da Costa RL; Departamento de Ciências Fisiológicas (DCF), Centro de Ciências Biológicas e da Saúde (CCBS), Universidade Federal de São Carlos (UFSCar), 13565-905, São Carlos, São Paulo, Brazil; Programa de Pós-Graduação Em Ciências Ambientais (PPGCAm), Centro de Ciências Biológicas e da Saúde (CCBS), Universidade Federal de São Carlos (UFSCar), Brazil., Souza IC; Departamento de Ciências Fisiológicas (DCF), Centro de Ciências Biológicas e da Saúde (CCBS), Universidade Federal de São Carlos (UFSCar), 13565-905, São Carlos, São Paulo, Brazil., Morozesk M; Departamento de Ciências Fisiológicas (DCF), Centro de Ciências Biológicas e da Saúde (CCBS), Universidade Federal de São Carlos (UFSCar), 13565-905, São Carlos, São Paulo, Brazil., de Carvalho LB; Departamento de Ciências Fisiológicas (DCF), Centro de Ciências Biológicas e da Saúde (CCBS), Universidade Federal de São Carlos (UFSCar), 13565-905, São Carlos, São Paulo, Brazil; Programa de Pós-Graduação Em Ciências Ambientais (PPGCAm), Centro de Ciências Biológicas e da Saúde (CCBS), Universidade Federal de São Carlos (UFSCar), 13565-905, São Carlos, São Paulo, Brazil., Carvalho CDS; Departamento de Biologia (DBio), Centro de Ciências Humanas e Biológicas (CCHB), Universidade Federal de São Carlos (UFSCar), 18052-780, São Carlos, São Paulo, Brazil., Monferrán MV; ICYTAC, Instituto de Ciencia y Tecnología de Alimentos Córdoba, CONICET and Dpto. Qca. Orgánica, Fac. Cs. Químicas, Universidad Nacional de Córdoba, Ciudad Universitaria, 5000, Córdoba, Argentina., Wunderlin DA; ICYTAC, Instituto de Ciencia y Tecnología de Alimentos Córdoba, CONICET and Dpto. Qca. Orgánica, Fac. Cs. Químicas, Universidad Nacional de Córdoba, Ciudad Universitaria, 5000, Córdoba, Argentina., Fernandes MN; Departamento de Ciências Fisiológicas (DCF), Centro de Ciências Biológicas e da Saúde (CCBS), Universidade Federal de São Carlos (UFSCar), 13565-905, São Carlos, São Paulo, Brazil., Monteiro DA; Departamento de Ciências Fisiológicas (DCF), Centro de Ciências Biológicas e da Saúde (CCBS), Universidade Federal de São Carlos (UFSCar), 13565-905, São Carlos, São Paulo, Brazil. Electronic address: dianamonteiro@ufscar.br.
المصدر:	Environmental pollution (Barking, Essex : 1987) [Environ Pollut] 2024 Jan 01; Vol. 340 (Pt 1), pp. 122846. Date of Electronic Publication: 2023 Nov 03.
نوع المنشور:	Journal Article
اللغة:	English
بيانات الدورية:	Publisher: Elsevier Applied Science Publishers Country of Publication: England NLM ID: 8804476 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6424 (Electronic) Linking ISSN: 02697491 NLM ISO Abbreviation: Environ Pollut Subsets: MEDLINE
أسماء مطبوعة:	Original Publication: Barking, Essex, England : Elsevier Applied Science Publishers, c1987-
مواضيع طبية MeSH:	Mutagens/toxicity , DNA Damage, Animals ; United States ; Rana catesbeiana ; Bioaccumulation ; Hemoglobins
مستخلص:	Amphibians are more susceptible to environmental stressors than other vertebrates due to their semipermeable skin and physiological adaptations to living in very specific microhabitats. Therefore, the aim of the present study was to investigate the effects of a metal mixture from settleable particulate matter (SePM) released from metallurgical industries on Lithobates catesbeianus tadpoles. Endpoints analyzed included metal bioconcentration, morphological (biometrical indices), hematological parameters (hemoglobin and blood cell count), and erythrocyte DNA damage (genotoxicity and mutagenicity). American bullfrog tadpoles (Gosner's stage 25) were kept under control condition (no contaminant addition) or exposed to a sub-lethal and environmentally relevant concentration (1 g.L ^-1 ) of SePM for 96 h. Tadpoles exposed to SePM exhibited elevated whole blood levels of Fe ⁵⁶ , AL, Sn, Pb, Zn, Cr, Cu, Ti, Rb, V, Ce, La, Ag, As. SePM-exposed tadpoles showed a significant decrease in condition factor (12%) and increases in hepatosomatic index (25%), hemoglobin concentration (17%), and total leukocytes (82%), thrombocytes (90%), and monocytes (78%) abundance. In addition, exposed tadpoles showed higher MN and ENAs (340 and 140%, respectively) frequencies, and erythrocyte DNA damage with approximately 1.2- to 1.8-fold increases in comet parameters. Taken together, these results suggest that the multimetal mixture found in SePM is potentially genotoxic and mutagenic to L. catesbeianus tadpoles, induces stress associated with hematological changes, and negatively affects growth. Although such contamination occurs at sublethal levels, regulatory standards are needed to control the emission of SePM and protect amphibian populations. Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2023 Elsevier Ltd. All rights reserved.)
فهرسة مساهمة:	Keywords: Amphibian; Erythrocytic nuclear abnormalities; Metal mixture; Micronucleus; Pollution; Stress response
المشرفين على المادة:	0 (Mutagens) 0 (Hemoglobins)
تواريخ الأحداث:	Date Created: 20231105 Date Completed: 20231121 Latest Revision: 20231121
رمز التحديث:	20240628
DOI:	10.1016/j.envpol.2023.122846
PMID:	37926415
قاعدة البيانات:	MEDLINE

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تدمد:	1873-6424
DOI:	10.1016/j.envpol.2023.122846