دورية أكاديمية
The Complexity of Shapes: How the Circularity of Tumor Nodules Affects Prognosis in Colorectal Cancer.
| العنوان: | The Complexity of Shapes: How the Circularity of Tumor Nodules Affects Prognosis in Colorectal Cancer. |
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| المؤلفون: | Brouwer NPM; Department of pathology, Radboud University Medical Center, Nijmegen, The Netherlands. Electronic address: Nelleke.brouwer@radboudumc.nl., Khan A; Institute of Tissue Medicine and Pathology, University of Bern, Bern, Switzerland., Bokhorst JM; Department of pathology, Radboud University Medical Center, Nijmegen, The Netherlands., Ayatollahi F; Department of pathology, Radboud University Medical Center, Nijmegen, The Netherlands., Hay J; Glasgow Tissue Research Facility, University of Glasgow, Queen Elizabeth University Hospital, Glasgow, United Kingdom., Ciompi F; Department of pathology, Radboud University Medical Center, Nijmegen, The Netherlands., Simmer F; Department of pathology, Radboud University Medical Center, Nijmegen, The Netherlands., Hugen N; Department of Surgery, Netherlands Cancer Institute, Amsterdam, The Netherlands., de Wilt JHW; Department of Surgery, Radboud University Medical Center, Nijmegen, The Netherlands., Berger MD; Department of Medical Oncology, Inselspital, University Hospital of Bern, University of Bern, Bern, Switzerland., Lugli A; Institute of Tissue Medicine and Pathology, University of Bern, Bern, Switzerland., Zlobec I; Institute of Tissue Medicine and Pathology, University of Bern, Bern, Switzerland., Edwards J; School of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom., Nagtegaal ID; Department of pathology, Radboud University Medical Center, Nijmegen, The Netherlands. |
| المصدر: | Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc [Mod Pathol] 2024 Jan; Vol. 37 (1), pp. 100376. Date of Electronic Publication: 2023 Nov 03. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Inc Country of Publication: United States NLM ID: 8806605 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1530-0285 (Electronic) Linking ISSN: 08933952 NLM ISO Abbreviation: Mod Pathol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2023- : [New York] : Elsevier Inc. Original Publication: Baltimore, MD : Williams & Wilkins, c1988- |
| مواضيع طبية MeSH: | Colorectal Neoplasms*/pathology, Humans ; Prognosis ; Neoplasm Staging ; Disease-Free Survival ; Proportional Hazards Models ; Retrospective Studies ; Lymph Nodes/pathology |
| مستخلص: | The current stratification of tumor nodules in colorectal cancer (CRC) staging is subjective and leads to high interobserver variability. In this study, the objective assessment of the shape of lymph node metastases (LNMs), extranodal extension (ENE), and tumor deposits (TDs) was correlated with outcomes. A test cohort and a validation cohort were included from 2 different institutions. The test cohort consisted of 190 cases of stage III CRC. Slides with LNMs and TDs were annotated and processed using a segmentation algorithm to determine their shape. The complexity ratio was calculated for every shape and correlated with outcomes. A cohort of 160 stage III CRC cases was used to validate findings. TDs showed significantly more complex shapes than LNMs with ENE, which were more complex than LNMs without ENE (P < .001). In the test cohort, patients with the highest sum of complexity ratios had significantly lower disease-free survival (P < .01). When only the nodule with the highest complexity was considered, this effect was even stronger (P < .001). This maximum complexity ratio per patient was identified as an independent prognostic factor in the multivariate analysis (hazard ratio, 2.47; P < .05). The trends in the validation cohort confirmed the results. More complex nodules in stage III CRC were correlated with significantly worse disease-free survival, even if only based on the most complex nodule. These results suggest that more complex nodules reflect more invasive tumor biology. As most of the more complex nodules were diagnosed as TDs, we suggest providing a more prominent role for TDs in the nodal stage and include an objective complexity measure in their definition. (Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: artificial intelligence; colorectal cancer; extranodal extension; lymph node metastases; shape; tumor deposits |
| تواريخ الأحداث: | Date Created: 20231105 Date Completed: 20240122 Latest Revision: 20240122 |
| رمز التحديث: | 20240122 |
| DOI: | 10.1016/j.modpat.2023.100376 |
| PMID: | 37926423 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1530-0285 |
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| DOI: | 10.1016/j.modpat.2023.100376 |