Extracellular vesicles from non-neuroendocrine SCLC cells promote adhesion and survival of neuroendocrine SCLC cells.

التفاصيل البيبلوغرافية
العنوان:	Extracellular vesicles from non-neuroendocrine SCLC cells promote adhesion and survival of neuroendocrine SCLC cells.
المؤلفون:	Jimenez L; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.; Center for Extracellular Vesicle Research, Vanderbilt University, Nashville, Tennessee, USA., Stolzenbach V; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.; Center for Extracellular Vesicle Research, Vanderbilt University, Nashville, Tennessee, USA., Ozawa PMM; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.; Center for Extracellular Vesicle Research, Vanderbilt University, Nashville, Tennessee, USA., Ramirez-Solano M; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Liu Q; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Sage J; Department of Pediatrics, Stanford Medicine, Stanford, California, USA.; Department of Genetics, Stanford Medicine, Stanford, California, USA., Weaver AM; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.; Center for Extracellular Vesicle Research, Vanderbilt University, Nashville, Tennessee, USA.; Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
المصدر:	Proteomics [Proteomics] 2024 Jun; Vol. 24 (11), pp. e2300030. Date of Electronic Publication: 2023 Nov 05.
نوع المنشور:	Journal Article
اللغة:	English
بيانات الدورية:	Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101092707 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1615-9861 (Electronic) Linking ISSN: 16159853 NLM ISO Abbreviation: Proteomics Subsets: MEDLINE
أسماء مطبوعة:	Original Publication: Weinheim, Germany : Wiley-VCH,
مواضيع طبية MeSH:	Small Cell Lung Carcinoma/metabolism , Small Cell Lung Carcinoma/pathology , Small Cell Lung Carcinoma/genetics , Cell Adhesion , Lung Neoplasms/metabolism , Lung Neoplasms/pathology , Lung Neoplasms/genetics , Extracellular Vesicles/metabolism , Cell Survival*, Humans ; Cell Line, Tumor ; Extracellular Matrix Proteins/metabolism ; Proteomics/methods ; Laminin/metabolism
مستخلص:	Small cell lung cancer (SCLC) tumors are made up of distinct cell subpopulations, including neuroendocrine (NE) and non-neuroendocrine (non-NE) cells. While secreted factors from non-NE SCLC cells have been shown to support the growth of the NE cells, the underlying molecular factors are not well understood. Here, we show that exosome-type small extracellular vesicles (SEVs) secreted from non-NE SCLC cells promote adhesion and survival of NE SCLC cells. Proteomic analysis of purified SEVs revealed that extracellular matrix (ECM) proteins and integrins are highly enriched in SEVs of non-NE cells whereas nucleic acid-binding proteins are enriched in SEVs purified from NE cells. Addition of select purified ECM proteins identified in purified extracellular vesicles (EVs), specifically fibronectin, laminin 411, and laminin 511, were able to substitute for the role of non-NE-derived SEVs in promoting adhesion and survival of NE SCLC cells. Those same proteins were differentially expressed by human SCLC subtypes. These data suggest that ECM-carrying SEVs secreted by non-NE cells play a key role in supporting the growth and survival of NE SCLC cells. (© 2023 Wiley‐VCH GmbH.)
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معلومات مُعتمدة:	F32 CA217064 United States CA NCI NIH HHS; P30 CA068485 United States CA NCI NIH HHS; U01 CA224276 United States CA NCI NIH HHS; U54 CA217450 United States CA NCI NIH HHS; F32 CA217064 United States CA NCI NIH HHS; P30 CA068485 United States CA NCI NIH HHS; U01 CA224276 United States CA NCI NIH HHS; U54 CA217450 United States CA NCI NIH HHS
فهرسة مساهمة:	Keywords: ECM; SCLC; extracellular vesicles; proteomics; tumor heterogeneity
المشرفين على المادة:	0 (Extracellular Matrix Proteins) 0 (Laminin)
تواريخ الأحداث:	Date Created: 20231105 Date Completed: 20240603 Latest Revision: 20240603
رمز التحديث:	20240603
DOI:	10.1002/pmic.202300030
PMID:	37926756
قاعدة البيانات:	MEDLINE

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تدمد:	1615-9861
DOI:	10.1002/pmic.202300030