دورية أكاديمية
Profile and Outcome of Prospective Non-Septic Lateral Sinus Thrombosis Patients from a Stroke Unit of a Developing Country.
| العنوان: | Profile and Outcome of Prospective Non-Septic Lateral Sinus Thrombosis Patients from a Stroke Unit of a Developing Country. |
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| المؤلفون: | Mirza AM; Department of Neurology, National Institute of Mental Health and Neurosciences (NIMHANS), Hosur Road, Bengaluru, Karnataka, India., Kulkarni GB; Department of Neurology, National Institute of Mental Health and Neurosciences (NIMHANS), Hosur Road, Bengaluru, Karnataka, India., Ramakrishnan S; Department of Neurology, National Institute of Mental Health and Neurosciences (NIMHANS), Hosur Road, Bengaluru, Karnataka, India., Mustare V; Department of Neurology, National Institute of Mental Health and Neurosciences (NIMHANS), Hosur Road, Bengaluru, Karnataka, India., Yadav R; Department of Neurology, National Institute of Mental Health and Neurosciences (NIMHANS), Hosur Road, Bengaluru, Karnataka, India., Gupta AK; Department of Neuroimaging and Interventional Radiology, National Institute of Mental Health and Neurosciences (NIMHANS), Hosur Road, Bengaluru, Karnataka, India. |
| المصدر: | Neurology India [Neurol India] 2023 Sep-Oct; Vol. 71 (5), pp. 916-922. |
| نوع المنشور: | Observational Study; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Medknow Publications Country of Publication: India NLM ID: 0042005 Publication Model: Print Cited Medium: Internet ISSN: 1998-4022 (Electronic) Linking ISSN: 00283886 NLM ISO Abbreviation: Neurol India Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Mumbai : Medknow Publications Original Publication: Bombay : Neurological Society of India |
| مواضيع طبية MeSH: | Lateral Sinus Thrombosis*/diagnosis , Lateral Sinus Thrombosis*/etiology , Lateral Sinus Thrombosis*/therapy , Stroke*/therapy , Stroke*/complications , Sinus Thrombosis, Intracranial*/complications , Sinus Thrombosis, Intracranial*/diagnosis , Sinus Thrombosis, Intracranial*/therapy, Humans ; Male ; Female ; Young Adult ; Adult ; Cohort Studies ; Prospective Studies ; Developing Countries ; Tomography, X-Ray Computed ; Magnetic Resonance Imaging ; Retrospective Studies |
| مستخلص: | Background: Due to effective treatment of middle ear infections there is a change in etiologies causing lateral sinus thrombosis (LST) and outcome. There is a paucity of literature describing homogenous group of patients with nonseptic LST (NS-LST). Objective: To describe the clinical profile, risk factors, outcome of patients of NS-LST seen at a single center from South India. Methods and Materials: Prospective, observational study of 100 patients of NS-LST patients, diagnosed by magnetic resonance imaging (MRI) seen at the stroke unit. Results: During 2 years, 100 patients of NS-LST (isolated: combined: 27:73) (male: female: 44:56), mean age: 31.45 ± 11.13 years, were seen. Subacute presentation (74%) with headache, seizures, focal deficits, and features of raised intracranial pressure were presenting features. Hyperhomocysteinemia (61%), anemia (57%), postpartum state (41%), OCP use (37%), and low VitB12 (32%) were commonly seen risk factors. Imaging with MRI compared withcomputerized tomography (CT) had better diagnostic sensitivity (100% vs. 67%), detection of parenchymal (81% vs. 67%)/hemorrhagic (79% vs. 74%) lesions, and cortical vein thrombosis (31% vs. 15.46%). Treatment with anticoagulation and supportive therapy resulted in good outcome (mRS (0-2)) at 3 months in 81%.There were four deaths, all during admission (one - isolated, three - combined) and 11 patients underwent decompressive surgery. Patients with low GCS level of sensoriumat admission, hemiparesis, combined LST, cerebellar involvement, and decompressive craniectomy had a poor outcome. Conclusion: This single-center large cohort study of NS-LST patients brings out the clinical features, risk factors (peculiar to developing countries), and the superiority of MRI in the diagnosis. Majority of patients have good outcome, with low mortality with 10% requiring decompressive surgery. Competing Interests: None |
| فهرسة مساهمة: | Keywords: Anticoagulation; lateral sinus; stroke; thrombosis; venous stroke |
| تواريخ الأحداث: | Date Created: 20231106 Date Completed: 20231107 Latest Revision: 20231107 |
| رمز التحديث: | 20240628 |
| DOI: | 10.4103/0028-3886.388114 |
| PMID: | 37929427 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1998-4022 |
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| DOI: | 10.4103/0028-3886.388114 |