دورية أكاديمية

Evaluation of the ceftazidime/avibactam and meropenem susceptibility by MALDI-TOF MS directly from positive blood cultures.

التفاصيل البيبلوغرافية
العنوان: Evaluation of the ceftazidime/avibactam and meropenem susceptibility by MALDI-TOF MS directly from positive blood cultures.
المؤلفون: Wilhelm CM; Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil. camilawilhelm@gmail.com.; Laboratório de Pesquisa em Resistência Bacteriana (LABRESIS), Hospital de Clínicas de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil. camilawilhelm@gmail.com., Moreira NK; Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.; Laboratório de Pesquisa em Resistência Bacteriana (LABRESIS), Hospital de Clínicas de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil., Inamine E; Irmandade Santa Casa de Misericórdia de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil., Caierão J; Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil., Barth AL; Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.; Laboratório de Pesquisa em Resistência Bacteriana (LABRESIS), Hospital de Clínicas de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil.
المصدر: European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology [Eur J Clin Microbiol Infect Dis] 2024 Jan; Vol. 43 (1), pp. 171-175. Date of Electronic Publication: 2023 Nov 07.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer Country of Publication: Germany NLM ID: 8804297 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1435-4373 (Electronic) Linking ISSN: 09349723 NLM ISO Abbreviation: Eur J Clin Microbiol Infect Dis Subsets: MEDLINE
أسماء مطبوعة: Publication: Berlin : Springer
Original Publication: [Wiesbaden, Federal Republic of Germany] : Vieweg, [c1988-
مواضيع طبية MeSH: Ceftazidime*/pharmacology , Blood Culture*, Humans ; Meropenem/pharmacology ; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization ; Anti-Bacterial Agents/pharmacology ; Drug Combinations ; Microbial Sensitivity Tests ; beta-Lactamases
مستخلص: The purpose of this study was to evaluate the MBT-ASTRA to determine susceptibility to ceftazidime/avibactam (CZA) and meropenem (MEM) of Enterobacterales directly from positive blood cultures (BC). Bacterial suspension was incubated with antibiotic and analyzed by MALDI-TOF MS. The relative growth was calculated and cutoff values were determined to categorize isolates as "S," "I," and "R." Klebsiella spp. with CZA 20/8 mg/L and 1.5-h incubation presented 1 (5.9%) major discrepancy and 96.3% category agreement; other species required 2.5 h for 100% category agreement. For MEM, 4 mg/L and 1.5h were necessary, demonstrating 2 (6.67%) minor discrepancies and 93.3% categorical agreement.
(© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
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فهرسة مساهمة: Keywords: Antimicrobial susceptibility testing; Blood culture; Ceftazidime/avibactam; MALDI-TOF MS; Meropenem
المشرفين على المادة: 9M416Z9QNR (Ceftazidime)
FV9J3JU8B1 (Meropenem)
7352665165 (avibactam)
0 (Anti-Bacterial Agents)
0 (Drug Combinations)
EC 3.5.2.6 (beta-Lactamases)
تواريخ الأحداث: Date Created: 20231106 Date Completed: 20240109 Latest Revision: 20240109
رمز التحديث: 20240109
DOI: 10.1007/s10096-023-04696-5
PMID: 37932585
قاعدة البيانات: MEDLINE
الوصف
تدمد:1435-4373
DOI:10.1007/s10096-023-04696-5