دورية أكاديمية
Evaluation of the ceftazidime/avibactam and meropenem susceptibility by MALDI-TOF MS directly from positive blood cultures.
العنوان: | Evaluation of the ceftazidime/avibactam and meropenem susceptibility by MALDI-TOF MS directly from positive blood cultures. |
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المؤلفون: | Wilhelm CM; Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil. camilawilhelm@gmail.com.; Laboratório de Pesquisa em Resistência Bacteriana (LABRESIS), Hospital de Clínicas de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil. camilawilhelm@gmail.com., Moreira NK; Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.; Laboratório de Pesquisa em Resistência Bacteriana (LABRESIS), Hospital de Clínicas de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil., Inamine E; Irmandade Santa Casa de Misericórdia de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil., Caierão J; Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil., Barth AL; Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.; Laboratório de Pesquisa em Resistência Bacteriana (LABRESIS), Hospital de Clínicas de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil. |
المصدر: | European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology [Eur J Clin Microbiol Infect Dis] 2024 Jan; Vol. 43 (1), pp. 171-175. Date of Electronic Publication: 2023 Nov 07. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Springer Country of Publication: Germany NLM ID: 8804297 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1435-4373 (Electronic) Linking ISSN: 09349723 NLM ISO Abbreviation: Eur J Clin Microbiol Infect Dis Subsets: MEDLINE |
أسماء مطبوعة: | Publication: Berlin : Springer Original Publication: [Wiesbaden, Federal Republic of Germany] : Vieweg, [c1988- |
مواضيع طبية MeSH: | Ceftazidime*/pharmacology , Blood Culture*, Humans ; Meropenem/pharmacology ; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization ; Anti-Bacterial Agents/pharmacology ; Drug Combinations ; Microbial Sensitivity Tests ; beta-Lactamases |
مستخلص: | The purpose of this study was to evaluate the MBT-ASTRA to determine susceptibility to ceftazidime/avibactam (CZA) and meropenem (MEM) of Enterobacterales directly from positive blood cultures (BC). Bacterial suspension was incubated with antibiotic and analyzed by MALDI-TOF MS. The relative growth was calculated and cutoff values were determined to categorize isolates as "S," "I," and "R." Klebsiella spp. with CZA 20/8 mg/L and 1.5-h incubation presented 1 (5.9%) major discrepancy and 96.3% category agreement; other species required 2.5 h for 100% category agreement. For MEM, 4 mg/L and 1.5h were necessary, demonstrating 2 (6.67%) minor discrepancies and 93.3% categorical agreement. (© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.) |
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فهرسة مساهمة: | Keywords: Antimicrobial susceptibility testing; Blood culture; Ceftazidime/avibactam; MALDI-TOF MS; Meropenem |
المشرفين على المادة: | 9M416Z9QNR (Ceftazidime) FV9J3JU8B1 (Meropenem) 7352665165 (avibactam) 0 (Anti-Bacterial Agents) 0 (Drug Combinations) EC 3.5.2.6 (beta-Lactamases) |
تواريخ الأحداث: | Date Created: 20231106 Date Completed: 20240109 Latest Revision: 20240109 |
رمز التحديث: | 20240109 |
DOI: | 10.1007/s10096-023-04696-5 |
PMID: | 37932585 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1435-4373 |
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DOI: | 10.1007/s10096-023-04696-5 |