دورية أكاديمية
Effects of irisin and exercise on adropin and betatrophin in a new metabolic syndrome model.
| العنوان: | Effects of irisin and exercise on adropin and betatrophin in a new metabolic syndrome model. |
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| المؤلفون: | Aydin S; Department of Cardiovascular Surgery, Fethi Sekin City Hospital, Elazig, Turkiye.; Department of Anatomy, School of Medicine, Firat University, Elazig, Turkiye.; Department of Histology and Embryology, School of Veterinary Medicine, Firat University, Elazig, Turkiye., Kilinc F; Department of Internal Medicine (Endocrinology and Metabolism Diseases), School of Medicine, Firat University, Elazig, Turkiye., Ugur K; Department of Internal Medicine (Endocrinology and Metabolism Diseases), School of Medicine, Firat University, Elazig, Turkiye., Aydin MA; School of Medicine, Gazi University, Ankara, Turkiye., Yalcin MH; Department of Histology and Embryology, School of Veterinary Medicine, Firat University, Elazig, Turkiye., Kuloglu T; Department of Histology and Embryology, School of Medicine, Firat University, Elazig, Turkiye., Kaya Tektemur N; Department of Histology and Embryology, School of Medicine, Firat University, Elazig, Turkiye., Albayrak S; Department of Brain and Nerve Surgery, Elazig Fethi Sekin City Hospital, Elazig, Turkiye., Emre E; Department of Anatomy, School of Medicine, Firat University, Elazig, Turkiye., Yardim M; Department of Medical Biochemistry, Faculty of Sport Sciences, Yerkoy State Hospital, Yozgat, Turkiye., Akkoc RF; Department of Anatomy, School of Medicine, Firat University, Elazig, Turkiye., Hancer S; Department of Histology and Embryology, School of Medicine, Firat University, Elazig, Turkiye., Sahin İ; Department of Medical Biochemistry and Clinical Biochemistry, Firat Hormones Research Group, Medical School, Firat University, Elazig, Turkiye.; Department of Medical Biology, Medical School, Erzincan Binali Yildirim University, Erzincan, Turkiye., Cinar V; Department of Physical Education and Sports Teaching, Faculty of Sport Sciences, Firat University, Elazig, Turkey., Akbulut T; Department of Sports and Health, Faculty of Sport Sciences, Firat University, Elazig, Turkiye., Demircan S; Department of Intensive Care, Inonu University Hospital, Malatya, Turkiye., Evren B; Department of Internal Medicine, School of Medicine, Inonu University, Malatya, Turkiye., Gencer BT; Department of Histology and Embryology, School of Veterinary Medicine, Firat University, Elazig, Turkiye., Aksoy A; Nature and Engineering Faculty, Malatya Turgut Ozal University, Malatya, Turkiye., Yilmaz Bozoglan M; Department of Medical Pharmacology, Medical School, Firat University, Elazig, Turkiye., Aydemir İ; Department of Physical Education and Sports Teaching, Faculty of Sport Sciences, Firat University, Elazig, Turkey., Aydin S; Department of Medical Biochemistry and Clinical Biochemistry, Firat Hormones Research Group, Medical School, Firat University, Elazig, Turkiye. |
| المصدر: | Biotechnic & histochemistry : official publication of the Biological Stain Commission [Biotech Histochem] 2024 Nov; Vol. 99 (1), pp. 21-32. Date of Electronic Publication: 2024 Jan 09. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Taylor & Francis Country of Publication: England NLM ID: 9107378 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1473-7760 (Electronic) Linking ISSN: 10520295 NLM ISO Abbreviation: Biotech Histochem Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2015- : Abingdon, Oxford : Taylor & Francis Original Publication: Baltimore; MD : Williams & Wilkins, c1991- |
| مواضيع طبية MeSH: | Fibronectins*/pharmacology , Fibronectins*/metabolism , Metabolic Syndrome*/therapy, Rats ; Animals ; Angiopoietin-Like Protein 8 ; Heart |
| مستخلص: | Metabolic syndrome (MetS) is a prevalent public health problem. Uric acid (UA) is increased by MetS. We investigated whether administration of UA and 10% fructose (F) would accelerate MetS formation and we also determined the effects of irisin and exercise. We used seven groups of rats. Group 1 (control); group 2 (sham); group 3 (10% F); group 4 (1% UA); group 5 (2% UA); group 6 (10% F + 1% UA); and Group 7, (10% F + 2% UA). After induction of MetS (groups 3 -7), Group 3 was divided into three subgroups: 3A, no further treatment; 3B, irisin treatment; 3C, irisin treatment + exercise. Group 4, 1% UA, which was divided into three subgroups: 4A, no further treatment; 4B, irisin treatment; 4C, Irisin treatment + exercise. Group 5, 2% UA, which was divided into three subgroups: 5A, no further treatment; 5B, irisin treatment; 5C, irisin treatment + exercise. Group 6, 10% F + 1% UA, which was divided into three subgroups: 6A, no further treatment; 6B, irisin treatment; 6C, irisin treatment + exercise. Group 7, 10% F + 2% UA, which was divided into three subgroups: 7A, no further treatment; 7B, irisin treatment; 7C, irisin treatment + exercise., İrisin was administered 10 ng/kg irisin intraperitoneally on Monday, Wednesday, Friday, Sunday each week for 1 month. The exercise animals (in addition to irisin treatment) also were run on a treadmill for 45 min on Monday, Wednesday, Friday, Sunday each week for 1 month. The rats were sacrificed and samples of liver, heart, kidney, pancreas, skeletal muscles and blood were obtained. The amounts of adropin (ADR) and betatrophin in the tissue supernatant and blood were measured using an ELISA method. Immunohistochemistry was used to detect ADR and betatrophin expression in situ in tissue samples. The duration of these experiments varied from 3 and 10 weeks. The order of development of MetS was: group 7, 3 weeks; group 6, 4 weeks; group 5, 6 weeks; group 4, 7 weeks; group 3, 10 weeks. Kidney, liver, heart, pancreas and skeletal muscle tissues are sources of adropin and betatrophin. In these tissues and in the circulation, adropin was decreased significantly, while betatrophin was increased significantly due to MetS; irisin + exercise reversed this situation. We found that the best method for creating a MetS model was F + UA2 supplementation. Our method is rapid and simple. Irisin + exercise was best for preventing MetS. |
| فهرسة مساهمة: | Keywords: Adropin; betatrophin; body mass index; exercise; fructose; human; irisin; metabolic syndrome; rats; uric acid |
| المشرفين على المادة: | 0 (Fibronectins) 0 (Angiopoietin-Like Protein 8) |
| تواريخ الأحداث: | Date Created: 20231107 Date Completed: 20240110 Latest Revision: 20240110 |
| رمز التحديث: | 20240110 |
| DOI: | 10.1080/10520295.2023.2276205 |
| PMID: | 37933453 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1473-7760 |
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| DOI: | 10.1080/10520295.2023.2276205 |