دورية أكاديمية
Left bundle branch pacing better preserves ventricular mechanical synchrony than right ventricular pacing: a two-centre study.
| العنوان: | Left bundle branch pacing better preserves ventricular mechanical synchrony than right ventricular pacing: a two-centre study. |
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| المؤلفون: | Mao Y; Department of Diagnostic Ultrasound and Echocardiography, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.; Department of Cardiovascular Sciences, KU Leuven, Herestraat 49, Leuven 3000, Belgium., Duchenne J; Department of Cardiovascular Sciences, KU Leuven, Herestraat 49, Leuven 3000, Belgium., Yang Y; Department of Diagnostic Ultrasound and Echocardiography, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China., Garweg C; Department of Cardiovascular Sciences, KU Leuven, Herestraat 49, Leuven 3000, Belgium.; Department of Cardiovascular Diseases, University Hospitals Leuven, Herestraat 49, Leuven 3000, Belgium., Yang Y; Department of Cardiology, Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, East Qingchun Road 3, Hangzhou 310016, China., Sheng X; Department of Cardiology, Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, East Qingchun Road 3, Hangzhou 310016, China., Zhang J; Department of Cardiology, Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, East Qingchun Road 3, Hangzhou 310016, China., Ye Y; Department of Cardiology, Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, East Qingchun Road 3, Hangzhou 310016, China., Wang M; Department of Cardiology, Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, East Qingchun Road 3, Hangzhou 310016, China., Paton MF; Department of Cardiovascular Sciences, KU Leuven, Herestraat 49, Leuven 3000, Belgium.; Leeds Institute of Cardiovascular and Metabolic Medicine, Multidisciplinary Cardiovascular Research Centre, University of Leeds, Leeds, UK.; Leeds Cardiovascular Clinical Research Facility, Leeds Teaching Hospitals NHS Trust, Leeds, UK., Puvrez A; Department of Cardiovascular Sciences, KU Leuven, Herestraat 49, Leuven 3000, Belgium.; Department of Cardiovascular Diseases, University Hospitals Leuven, Herestraat 49, Leuven 3000, Belgium., Vöros G; Department of Cardiovascular Sciences, KU Leuven, Herestraat 49, Leuven 3000, Belgium.; Department of Cardiovascular Diseases, University Hospitals Leuven, Herestraat 49, Leuven 3000, Belgium., Ma M; Department of Diagnostic Ultrasound and Echocardiography, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China., Fu G; Department of Cardiology, Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, East Qingchun Road 3, Hangzhou 310016, China., Voigt JU; Department of Cardiovascular Sciences, KU Leuven, Herestraat 49, Leuven 3000, Belgium.; Department of Cardiovascular Diseases, University Hospitals Leuven, Herestraat 49, Leuven 3000, Belgium. |
| المصدر: | European heart journal. Cardiovascular Imaging [Eur Heart J Cardiovasc Imaging] 2024 Feb 22; Vol. 25 (3), pp. 328-336. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: England NLM ID: 101573788 Publication Model: Print Cited Medium: Internet ISSN: 2047-2412 (Electronic) Linking ISSN: 20472404 NLM ISO Abbreviation: Eur Heart J Cardiovasc Imaging Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Oxford : Oxford University Press |
| مواضيع طبية MeSH: | Cardiac Pacing, Artificial*/methods , Ventricular Septum*, Humans ; Electrocardiography ; Heart Ventricles/diagnostic imaging ; Heart Conduction System ; Ventricular Function, Left/physiology ; Ventricular Remodeling ; Treatment Outcome |
| مستخلص: | Aims: Left bundle branch pacing (LBBP) has been shown to better maintain electrical synchrony compared with right ventricular pacing (RVP), but little is known about its impact on mechanical synchrony. This study investigates whether LBBP better preserves left ventricular (LV) mechanical synchronicity and function compared with RVP. Methods and Results: Sixty patients with pacing indication for bradycardia were included: LBBP (n = 31) and RVP (n = 29). Echocardiography was performed before and shortly after pacemaker implantation and at 1-year follow-up. The lateral wall-septal wall (LW-SW) work difference was used as a measure of mechanical dyssynchrony. Septal flash, apical rocking, and septal strain patterns were also assessed. At baseline, LW-SW work difference was small and similar in two groups. SW was markedly decreased, while LW work remained mostly unchanged in RVP, resulting in a larger LW-SW work difference compared with LBBP (1253 ± 687 mmHg·% vs. 439 ± 408 mmHg·%, P < 0.01) at last follow-up. In addition, RVP more often induced septal flash or apical rocking and resulted in more advanced strain patterns compared with LBBP. At 1 year follow-up, LV ejection fraction (EF) and global longitudinal strain (GLS) were more decreased in RVP compared with LBBP (ΔLVEF: -7.4 ± 7.0% vs. 0.3 ± 4.1%; ΔLVGLS: -4.8 ± 4.0% vs. -1.4 ± 2.5%, both P < 0.01). In addition, ΔLW-SW work difference was independently correlated with LV adverse remodelling (r = 0.42, P < 0.01) and LV dysfunction (ΔLVEF: r = -0.61, P < 0.01 and ΔLVGLS: r = -0.38, P = 0.02). Conclusion: LBBP causes less LV mechanical dyssynchrony than RVP as it preserves a more physiologic electrical conduction. As a consequence, LBBP appears to preserve LV function better than RVP. Competing Interests: Conflict of interests: None declared. (© The Author(s) 2023. Published by Oxford University Press on behalf of the European Society of Cardiology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.) |
| التعليقات: | Comment in: Eur Heart J Cardiovasc Imaging. 2023 Nov 15;:. (PMID: 37966280) |
| معلومات مُعتمدة: | 12ZZN22N Research Foundation Flanders; 2020KY165 Medical Health Science and Technology Program of Zhejiang Province; LY21H020006 Natural Science Foundation Of Zhejiang Province; NIHR31225 National Institute for Health Research Clinical Lectureship |
| فهرسة مساهمة: | Keywords: left bundle branch pacing; mechanical dyssynchrony; myocardial work; speckle tracking echocardiography |
| تواريخ الأحداث: | Date Created: 20231107 Date Completed: 20240226 Latest Revision: 20240226 |
| رمز التحديث: | 20240226 |
| DOI: | 10.1093/ehjci/jead296 |
| PMID: | 37933672 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2047-2412 |
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| DOI: | 10.1093/ehjci/jead296 |