دورية أكاديمية
Sublethal Toxicity of 17 Per- and Polyfluoroalkyl Substances with Diverse Structures to Ceriodaphnia dubia, Hyalella azteca, and Chironomus dilutus.
| العنوان: | Sublethal Toxicity of 17 Per- and Polyfluoroalkyl Substances with Diverse Structures to Ceriodaphnia dubia, Hyalella azteca, and Chironomus dilutus. |
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| المؤلفون: | Kadlec SM; Great Lakes Toxicology and Ecology Division, Center for Computational Toxicology and Exposure, Office of Research and Development, US Environmental Protection Agency, Duluth, Minnesota, USA., Backe WJ; Great Lakes Toxicology and Ecology Division, Center for Computational Toxicology and Exposure, Office of Research and Development, US Environmental Protection Agency, Duluth, Minnesota, USA., Erickson RJ; Great Lakes Toxicology and Ecology Division, Center for Computational Toxicology and Exposure, Office of Research and Development, US Environmental Protection Agency, Duluth, Minnesota, USA., Hockett JR; Great Lakes Toxicology and Ecology Division, Center for Computational Toxicology and Exposure, Office of Research and Development, US Environmental Protection Agency, Duluth, Minnesota, USA., Howe SE; Great Lakes Toxicology and Ecology Division, Center for Computational Toxicology and Exposure, Office of Research and Development, US Environmental Protection Agency, Duluth, Minnesota, USA.; Oak Ridge Associated Universities, Duluth, Minnesota, USA., Mundy ID; Great Lakes Toxicology and Ecology Division, Center for Computational Toxicology and Exposure, Office of Research and Development, US Environmental Protection Agency, Duluth, Minnesota, USA., Piasecki E; Great Lakes Toxicology and Ecology Division, Center for Computational Toxicology and Exposure, Office of Research and Development, US Environmental Protection Agency, Duluth, Minnesota, USA.; Oak Ridge Associated Universities, Duluth, Minnesota, USA., Sluka H; Great Lakes Toxicology and Ecology Division, Center for Computational Toxicology and Exposure, Office of Research and Development, US Environmental Protection Agency, Duluth, Minnesota, USA.; Oak Ridge Institute for Science and Education, Duluth, Minnesota, USA., Votava LK; Great Lakes Toxicology and Ecology Division, Center for Computational Toxicology and Exposure, Office of Research and Development, US Environmental Protection Agency, Duluth, Minnesota, USA.; Oak Ridge Associated Universities, Duluth, Minnesota, USA., Mount DR; Great Lakes Toxicology and Ecology Division, Center for Computational Toxicology and Exposure, Office of Research and Development, US Environmental Protection Agency, Duluth, Minnesota, USA. |
| المصدر: | Environmental toxicology and chemistry [Environ Toxicol Chem] 2024 Feb; Vol. 43 (2), pp. 359-373. Date of Electronic Publication: 2023 Dec 20. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: SETAC Press Country of Publication: United States NLM ID: 8308958 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-8618 (Electronic) Linking ISSN: 07307268 NLM ISO Abbreviation: Environ Toxicol Chem Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Pensacola, FL : SETAC Press Original Publication: New York : Pergamon Press, c1982- |
| مواضيع طبية MeSH: | Chironomidae* , Fluorocarbons*/analysis , Alkanesulfonic Acids* , Water Pollutants, Chemical*/analysis , Ants*, Animals ; Ceriodaphnia dubia ; Alkanesulfonates/pharmacology |
| مستخلص: | Seven-day sublethal toxicity tests were performed with the freshwater invertebrates Ceriodaphnia dubia, Hyalella azteca, and Chironomus dilutus to determine the effects of per- or polyfluorinated alkyl substances (PFAS) of varying chain length within four classes: perfluoroalkyl carboxylic acids (PFCAs), perfluoroalkyl sulfonic acids (PFSAs), perfluoroalkane sulfonamides, and fluorotelomer sulfonic acids. In general, toxicity increased with increasing chain length, but the slopes of these relationships varied markedly by species and chemical class. The toxicity of individual PFCAs was similar among species. The toxicity of PFSAs was similar to PFCAs for C. dubia and H. azteca, whereas PFSAs were much more toxic to C. dilutus, with median effect concentrations (EC50s) as low as 0.022 mg perfluorooctane sulfonate (PFOS)/L and 0.012 mg perfluorononane sulfonate (PFNS)/L. Despite the high sensitivity to PFOS and PFNS, C. dilutus was not very sensitive to structurally similar fluorotelomer sulfonates (6:2 and 8:2). Perfluoroalkane sulfonamides were the most toxic class tested among all species (e.g., EC50s of 0.011 and 0.017 mg perfluorooctane sulfonamide/L for C. dilutus and H. azteca, respectively). The differences in toxicity among species and chemical classes suggest that mechanisms of PFAS toxicity may differ as a function of both. Environ Toxicol Chem 2024;43:359-373. Published 2023. This article is a U.S. Government work and is in the public domain in the USA. (Published 2023. This article is a U.S. Government work and is in the public domain in the USA.) |
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| معلومات مُعتمدة: | EPA999999 United States ImEPA Intramural EPA |
| فهرسة مساهمة: | Keywords: Aquatic toxicology; Invertebrates; Per- and polyfluorinated alkyl substances (PFAS); Sublethal toxicity; perfluorooctane sulfonate (PFOS); perfluorooctanoic acid (PFOA) |
| المشرفين على المادة: | 0 (Fluorocarbons) 9H2MAI21CL (perfluorooctane sulfonic acid) 0 (Alkanesulfonic Acids) 0 (Alkanesulfonates) 0 (Water Pollutants, Chemical) |
| SCR Organism: | Azteca |
| تواريخ الأحداث: | Date Created: 20231107 Date Completed: 20240125 Latest Revision: 20240607 |
| رمز التحديث: | 20240607 |
| مُعرف محوري في PubMed: | PMC11149059 |
| DOI: | 10.1002/etc.5784 |
| PMID: | 37933805 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1552-8618 |
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| DOI: | 10.1002/etc.5784 |