دورية أكاديمية
Tumor Control Probability and Small-Scale Monte Carlo Dosimetry: Effects of Heterogenous Intratumoral Activity Distribution in Radiopharmaceutical Therapy.
| العنوان: | Tumor Control Probability and Small-Scale Monte Carlo Dosimetry: Effects of Heterogenous Intratumoral Activity Distribution in Radiopharmaceutical Therapy. |
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| المؤلفون: | Mellhammar E; Oncology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden; emma.mellhammar@med.lu.se., Dahlbom M; Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, California., Vilhelmsson-Timmermand O; Oncology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden.; Imaging Chemistry and Biology, King's College London, London, United Kingdom; and., Strand SE; Oncology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden.; Medical Radiation Physics, Department of Clinical Sciences Lund, Lund University, Lund, Sweden. |
| المصدر: | Journal of nuclear medicine : official publication, Society of Nuclear Medicine [J Nucl Med] 2023 Oct; Vol. 64 (10), pp. 1632-1637. Date of Electronic Publication: 2023 Jul 27. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Society of Nuclear Medicine Country of Publication: United States NLM ID: 0217410 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1535-5667 (Electronic) Linking ISSN: 01615505 NLM ISO Abbreviation: J Nucl Med Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Reston, VA : Society of Nuclear Medicine Original Publication: [Chicago, Ill.] : S.N. Turiel & Assoc. |
| مواضيع طبية MeSH: | Radiopharmaceuticals* , Prostatic Neoplasms*, Male ; Humans ; Monte Carlo Method ; Radiometry ; Autoradiography |
| مستخلص: | In radiopharmaceutical therapy, intratumoral uptake of radioactivity usually leads to heterogeneous absorbed dose distribution. The likelihood of treatment success can be estimated with the tumor control probability (TCP), which requires accurate dosimetry, estimating the absorbed dose rate per unit activity to individual tumor cells. Methods: Xenograft cryosections of the prostate cancer cell line LNCaP treated with [ 177 Lu]Lu-PSMA-617 were evaluated with digital autoradiography and stained with hematoxylin and eosin. The digital autoradiography images were used to define the source in a Monte Carlo simulation of the absorbed dose, and the stained sections were used to detect the position of cell nuclei to relate the intratumoral absorbed dose heterogeneity to the cell density. Simulations were performed for 225 Ac, 177 Lu, and 90 Y. TCP was calculated to estimate the mean necessary injected activity for a high TCP. A hypothetical case of activity mainly taken up on the tumor borders was generated and used to simulate the absorbed dose. Results: The absorbed dose per decay to tumor cells was calculated from the staining and simulation results to avoid underestimating the tumor response from low absorbed doses in tumor regions with low cell density. The mean of necessary injected activity to reach a 90% TCP for 225 Ac, 177 Lu, and 90 Y was found to be 18.3 kBq (range, 18-22 kBq), 24.3 MBq (range, 20-29 MBq), and 5.6 MBq (range, 5-6 MBq), respectively. Conclusion: To account for the heterogeneous absorbed dose generated from nonuniform intratumoral activity uptake, dosimetry models can estimate the mean necessary activity to reach a sufficient TCP for treatment response. This approach is necessary to accurately evaluate the efficacy of suggested radiopharmaceuticals for therapy. (© 2023 by the Society of Nuclear Medicine and Molecular Imaging.) |
| فهرسة مساهمة: | Keywords: Monte Carlo dosimetry simulation; digital autoradiography; heterogeneity; radiopharmaceutical therapy; tumor control probability |
| المشرفين على المادة: | 0 (Radiopharmaceuticals) |
| تواريخ الأحداث: | Date Created: 20231107 Date Completed: 20231108 Latest Revision: 20240228 |
| رمز التحديث: | 20240228 |
| DOI: | 10.2967/jnumed.123.265523 |
| PMID: | 37934033 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1535-5667 |
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| DOI: | 10.2967/jnumed.123.265523 |