دورية أكاديمية
Impact of Liver Cirrhosis, Severity of Cirrhosis, and Portal Hypertension on the Difficulty and Outcomes of Laparoscopic and Robotic Major Liver Resections for Primary Liver Malignancies.
| العنوان: | Impact of Liver Cirrhosis, Severity of Cirrhosis, and Portal Hypertension on the Difficulty and Outcomes of Laparoscopic and Robotic Major Liver Resections for Primary Liver Malignancies. |
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| المؤلفون: | Cipriani F; Hepatobiliary Surgery Division, IRCCS San Raffaele Hospital, Milan, Italy., Aldrighetti L; Hepatobiliary Surgery Division, IRCCS San Raffaele Hospital, Milan, Italy., Ratti F; Hepatobiliary Surgery Division, IRCCS San Raffaele Hospital, Milan, Italy., Wu AGR; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Kabir T; Department of General Surgery, Sengkang General Hospital, Singapore, Singapore., Scatton O; Department of Digestive, HBP, and Liver Transplantation, Hôpital Pitié-Salpêtrière, Sorbonne Université, Paris, France., Lim C; Department of Digestive, HBP, and Liver Transplantation, Hôpital Pitié-Salpêtrière, Sorbonne Université, Paris, France., Zhang W; Hepatic Surgery Center and Hubei Key Laboratory of Hepato-Biliary-Pancreatic Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China., Sijberden J; Department of Surgery, Fondazione Poliambulanza, Brescia, Italy., Aghayan DL; The Intervention Centre and Department of HPB Surgery, Oslo University Hospital, Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Siow TF; Division of General Surgery, Department of Surgery, Far Eastern Memorial Hospital, New Taipei City, Taiwan., Dokmak S; Department of HPB Surgery and Liver Transplantation, Beaujon Hospital, University Paris Cite, Clichy, France., Coelho FF; Liver Surgery Unit, Department of Gastroenterology, University of Sao Paulo School of Medicine, Sao Paulo, Brazil., Herman P; Liver Surgery Unit, Department of Gastroenterology, University of Sao Paulo School of Medicine, Sao Paulo, Brazil., Marino MV; General Surgery Department, Azienda Ospedaliera Ospedali Riuniti Villa Sofia-Cervello, Palermo, Italy.; General Surgery Department, F. Tappeiner Hospital, Merano, Italy., Mazzaferro V; HPB Surgery and Liver Transplantation, Fondazione IRCCS Istituto Nazionale Tumori di Milano and University of Milan, Milan, Italy., Chiow AKH; Hepatopancreatobiliary Unit, Department of Surgery, Changi General Hospital, Singapore, Singapore., Sucandy I; Digestive Health Institute, AdventHealth Tampa, Tampa, Florida, USA., Ivanecz A; Department of Abdominal and General Surgery, University Medical Center Maribor, Maribor, Slovenia., Choi SH; Department of General Surgery, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Korea., Lee JH; Division of Hepato-Biliary and Pancreatic Surgery, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea., Gastaca M; Hepatobiliary Surgery and Liver Transplantation Unit, Biocruces Bizkaia Health Research Institute, Cruces University Hospital, University of the Basque Country, Bilbao, Spain., Vivarelli M; HPB Surgery and Transplantation Unit, United Hospital of Ancona, Department of Experimental and Clinical Medicine Polytechnic, University of Marche, Ancona, Italy., Giuliante F; Hepatobiliary Surgery Unit, Fondazione Policlinico Universitario A. Gemelli, IRCCS, Catholic University of the Sacred Heart, Rome, Italy., Ruzzenente A; General and Hepatobiliary Surgery, Department of Surgery, Dentistry, Gynecology, and Pediatrics, University of Verona, GB Rossi Hospital, Verona, Italy., Yong CC; Department of Surgery, Chang Gung Memorial Hospital, Kaohsiung, Taiwan., Yin M; Department of Hepatobiliary Surgery, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, China., Fondevila C; General and Digestive Surgery, Hospital Clinic, IDIBAPS, CIBERehd, University of Barcelona, Barcelona, Spain.; General and Digestive Surgery, Hospital Universitario La Paz, IdiPAZ, CIBERehd, Madrid, Spain., Efanov M; Department of Hepato-Pancreato-Biliary Surgery, Moscow Clinical Scientific Center, Moscow, Russia., Morise Z; Department of Surgery, Okazaki Medical Center, Fujita Health University School of Medicine, Okazaki, Japan., Di Benedetto F; HPB Surgery and Liver Transplant Unit, University of Modena and Reggio Emilia, Modena, Italy., Brustia R; Department of Digestive and Hepatobiliary and Pancreatic Surgery, AP-HP, Henri-Mondor Hospital, Creteil, France., Dalla Valle R; Hepatobiliary Surgery Unit, Department of Medicine and Surgery, University of Parma, Parma, Italy., Boggi U; Division of General and Transplant Surgery, University of Pisa, Pisa, Italy., Geller D; Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA., Belli A; Division of Hepatopancreatobiliary Surgical Oncology, Department of Abdominal Oncology, National Cancer Center - IRCCS-G. Pascale, Naples, Italy., Memeo R; Unit of Hepato-Pancreatc-Biliary Surgery, 'F. Miulli' General Regional Hospital, Acquaviva delle Fonti, Bari, Italy., Gruttadauria S; Department for the Treatment and Study of Abdominal Diseases and Abdominal Transplantation, Istituto di Ricovero e Cura a Carattere Scientifico-Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione (IRCCS-ISMETT), University of Pittsburgh Medical Center Italy, Palermo, Italy.; Department of General Surgery and Medical Surgical Specialties, University of Catania, Catania, Italy., Mejia A; The Liver Institute, Methodist Dallas Medical Center, Dallas, Texas, USA., Park JO; Department of Surgery, University of Washington Medical Center, Seattle, WA, USA., Rotellar F; HPB and Liver Transplant Unit, Department of General Surgery, Clinica Universidad de Navarra, Universidad de Navarra, Pamplona, Spain.; Institute of Health Research of Navarra (IdisNA), Pamplona, Spain., Choi GH; Division of Hepatopancreatobiliary Surgery, Department of Surgery, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea., Robles-Campos R; Department of General, Visceral and Transplantation Surgery, Clinic and University Hospital Virgen de la Arrixaca, IMIB-ARRIXACA, El Palmar, Murcia, Spain., Wang X; Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, China., Sutcliffe RP; Department of Hepatopancreatobiliary and Liver Transplant Surgery, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK., Pratschke J; Department of Surgery, Campus Charité Mitte and Campus Virchow-Klinikum, Charité-Universitätsmedizin, Corporate Member of Freie Universität Berlin, and Berlin Institute of Health, Berlin, Germany., Lai ECH; Department of Surgery, Pamela Youde Nethersole Eastern Hospital, Hong Kong SAR, China., Chong CCN; Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, New Territories, Hong Kong SAR, China., D'Hondt M; Department of Digestive and Hepatobiliary/Pancreatic Surgery, Groeninge Hospital, Kortrijk, Belgium., Monden K; Department of Surgery, Fukuyama City Hospital, Hiroshima, Japan., Lopez-Ben S; Hepatobiliary and Pancreatic Surgery Unit, Department of Surgery, Dr. Josep Trueta Hospital, IdIBGi, Girona, Spain., Kingham TP; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Ferrero A; Department of General and Oncological Surgery, Mauriziano Hospital, Turin, Italy., Ettorre GM; Division of General Surgery and Liver Transplantation, S. Camillo Forlanini Hospital, Rome, Italy., Cherqui D; Department of Hepatobiliary Surgery, Assistance Publique Hopitaux de Paris, Centre Hepato-Biliaire, Paul-Brousse Hospital, Villejuif, France., Liang X; Department of General Surgery, Sir Run-Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China., Soubrane O; Department of Digestive, Oncologic and Metabolic Surgery, Institute Mutualiste Montsouris, Universite Paris Descartes, Paris, France., Wakabayashi G; Center for Advanced Treatment of Hepatobiliary and Pancreatic Diseases, Ageo Central General Hospital, Saitama, Japan., Troisi RI; Department of Clinical Medicine and Surgery, Division of HPB, Minimally Invasive and Robotic Surgery, Federico II University Hospital Naples, Naples, Italy., Cheung TT; Department of Surgery, Queen Mary Hospital, The University of Hong Kong, Hong Kong SAR, China., Kato Y; Department of Surgery, Fujita Health University School of Medicine, Aichi, Japan., Sugioka A; Department of Surgery, Fujita Health University School of Medicine, Aichi, Japan., Han HS; Department of Surgery, Seoul National University Hospital Bundang, Seoul National University College of Medicine, Seoul, Korea., Long TCD; Department of Hepatopancreatobiliary Surgery, University Medical Center, University of Medicine and Pharmacy, Ho Chi Minh City, Vietnam., Liu Q; Faculty of Hepatopancreatobiliary Surgery, The First Medical Center of Chinese People's Liberation Army (PLA) General Hospital, Beijing, China., Liu R; Faculty of Hepatopancreatobiliary Surgery, The First Medical Center of Chinese People's Liberation Army (PLA) General Hospital, Beijing, China., Edwin B; The Intervention Centre and Department of HPB Surgery, Oslo University Hospital, Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Fuks D; Department of Digestive, Oncologic and Metabolic Surgery, Institute Mutualiste Montsouris, Universite Paris Descartes, Paris, France., Chen KH; Division of General Surgery, Department of Surgery, Far Eastern Memorial Hospital, New Taipei City, Taiwan., Abu Hilal M; Department of Surgery, Fondazione Poliambulanza, Brescia, Italy.; Department of Surgery, University Hospital Southampton, Southampton, UK., Goh BKP; Department of Hepatopancreatobiliary and Transplant Surgery, Singapore General Hospital and National Cancer Centre Singapore, Singapore, Singapore. bsgkp@hotmail.com.; Surgery Academic Clinical Programme, Duke National University of Singapore Medical School, Singapore, Singapore. bsgkp@hotmail.com. |
| مؤلفون مشاركون: | International Robotic and Laparoscopic Liver Resection Study Group Investigators |
| المصدر: | Annals of surgical oncology [Ann Surg Oncol] 2024 Jan; Vol. 31 (1), pp. 97-114. Date of Electronic Publication: 2023 Nov 07. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer Country of Publication: United States NLM ID: 9420840 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1534-4681 (Electronic) Linking ISSN: 10689265 NLM ISO Abbreviation: Ann Surg Oncol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2005- : New York, NY : Springer Original Publication: New York, NY : Raven Press, c1994- |
| مواضيع طبية MeSH: | Liver Neoplasms*/complications , Liver Neoplasms*/surgery , Robotic Surgical Procedures* , Laparoscopy*/methods , Hypertension, Portal*/etiology , Hypertension, Portal*/surgery, Humans ; Hepatectomy/methods ; Retrospective Studies ; Postoperative Complications/etiology ; Postoperative Complications/surgery ; Liver Cirrhosis/complications ; Liver Cirrhosis/surgery ; Liver Cirrhosis/pathology ; Length of Stay ; Propensity Score |
| مستخلص: | Background: Minimally invasive liver resections (MILR) offer potential benefits such as reduced blood loss and morbidity compared with open liver resections. Several studies have suggested that the impact of cirrhosis differs according to the extent and complexity of resection. Our aim was to investigate the impact of cirrhosis on the difficulty and outcomes of MILR, focusing on major hepatectomies. Methods: A total of 2534 patients undergoing minimally invasive major hepatectomies (MIMH) for primary malignancies across 58 centers worldwide were retrospectively reviewed. Propensity score (PSM) and coarsened exact matching (CEM) were used to compare patients with and without cirrhosis. Results: A total of 1353 patients (53%) had no cirrhosis, 1065 (42%) had Child-Pugh A and 116 (4%) had Child-Pugh B cirrhosis. Matched comparison between non-cirrhotics vs Child-Pugh A cirrhosis demonstrated comparable blood loss. However, after PSM, postoperative morbidity and length of hospitalization was significantly greater in Child-Pugh A cirrhosis, but these were not statistically significant with CEM. Comparison between Child-Pugh A and Child-Pugh B cirrhosis demonstrated the latter had significantly higher transfusion rates and longer hospitalization after PSM, but not after CEM. Comparison of patients with cirrhosis of all grades with and without portal hypertension demonstrated no significant difference in all major perioperative outcomes after PSM and CEM. Conclusions: The presence and severity of cirrhosis affected the difficulty and impacted the outcomes of MIMH, resulting in higher blood transfusion rates, increased postoperative morbidity, and longer hospitalization in patients with more advanced cirrhosis. As such, future difficulty scoring systems for MIMH should incorporate liver cirrhosis and its severity as variables. (© 2023. Society of Surgical Oncology.) |
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| معلومات مُعتمدة: | P30 CA008747 National Cancer Institute MSKCC core grant; LGF20H160028 zhejiang provincial public welfare fund |
| فهرسة مساهمة: | Investigator: NL Syn; M Prieto; C De Meyere; J Meurs; KK Ng; KF Lee; D Salimgereeva; R Alikhanov; N Thiruchelvam; JY Jang; M Kojima; JAP Kruger; V Lopez-Lopez; MCI Robert; R Montalti; M Giglio; B Lee; M D'Silva; HP Wang; F Pascual; M Saleh; S Yu; Z Chen; S Vani; F Ardito; U Giustizieri; D Citterio; F Mocchegiani; M Colasanti; G Berardi; Y Guzmán; KP Labadie; M Conticchio; E Dogeas; EF Kauffmann; M Giuffrida; D Sommacale; A Laurent; P Magistri; K Mishima; M Schmelzle; F Krenzien; P Kadam; CN Tang; J Ghotbi; ÅA Fretland; F Forchino; B Dalla Valle; J Zheng; A Mazzotta; PP Nghia; F Cauchy Keywords: Cirrhosis; Difficulty score; Laparoscopic hepatectomy; Laparoscopic liver; Minimally invasive hepatectomy; Minimally invasive liver |
| تواريخ الأحداث: | Date Created: 20231107 Date Completed: 20231207 Latest Revision: 20240423 |
| رمز التحديث: | 20240423 |
| DOI: | 10.1245/s10434-023-14376-5 |
| PMID: | 37936020 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1534-4681 |
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| DOI: | 10.1245/s10434-023-14376-5 |