دورية أكاديمية

Active lupus in Argentina: Results of a multicenter and national registry.

التفاصيل البيبلوغرافية
العنوان: Active lupus in Argentina: Results of a multicenter and national registry.
المؤلفون: Quintana RM; Grupo Oroño, Centro Regional de Enfermedades Autoinmunes y Reumáticas (GO-CREAR), Rosario, Argentina., García M; Department of Reumatologia, HIGA General San Martin, La Plata, Argentina., Garcia L; Department of Reumatologia, HIGA General San Martin, La Plata, Argentina., Gobbi C; Department of Reumatologia, Sanatorio Allende, Córdoba, Argentina., Alba P; Department of Reumatologia, Hospital Córdoba, Córdoba, Argentina., Bellomio V; Department of Reumatologia, Hospital Angel C. Padilla, Tucumán, Argentina., Roverano S; Department of Reumatologia, Hospital J.M. Cullen, Santa Fe, Argentina., Alvarez AP; Department of Reumatologia, Hospital Penna, Buenos Aires, Argentina., Graf CE; Department of Reumatologia, Centro Médico Mitre, Paraná, Argentina., Pisoni C; CEMIC, Buenos Aires, Argentina., Spindler A; Department of Reumatologia, Centro de Investigaciones Médicas Tucumán, Tucumán, Argentina., Gomez C; Department of Reumatologia, Hospital Central de Formosa, Formosa, Argentina., Figueredo HM; Department of Reumatologia, Hospital de Alta Complejidad Pte. Juan Domingo Perón, Formosa, Argentina., Papasidero S; Department of Reumatologia, Hospital General de Agudos Dr Enrique Tornú, Buenos Aires, Argentina., Paniego R; Department of Reumatologia, CePReR, Santa Rosa, La Pampa, Argentina., de la Vega MC; Department of Reumatologia, CEIM Investigaciones Médicas, Buenos Aires, Argentina., Civit E; Department of Reumatologia, Hospital del Carmen, Godoy Cruz, Argentina., Gonzalez Lucero L; Department of Reumatologia, Hospital Angel C. Padilla, Tucumán, Argentina., Martire MV; Department of Reumatologia, Hospital Italiano de La Plata, La Plata, Argentina., Aguila Maldonado R; Department of Reumatologia, HIGA General San Martin, La Plata, Argentina., Gordon S; Department of Reumatologia, HIGA Dr Alende, Mar del Plata, Argentina., Micelli M; Department of Reumatologia, Hospital General de Agudos José María Ramos Mejía, Buenos Aires, Argentina., Nieto R; Hospital Provincial de Rosario, Rosario, Argentina., Rausch G; Department of Reumatologia, Consultorio Privado, Rio Grande, Tierra del Fuego, Rio Grande, Argentina., Alarcón GS; Division of Clinical Immunology and Rheumatology, Department of Medicine, Marnix E Heersink School of Medicine, The University of Alabama at Birmingham, Birmingham, AL, USA., Pons-Estel B; Grupo Oroño, Centro Regional de Enfermedades Autoinmunes y Reumáticas (GO-CREAR), Rosario, Argentina., Pons-Estel G; Grupo Oroño, Centro Regional de Enfermedades Autoinmunes y Reumáticas (GO-CREAR), Rosario, Argentina.
مؤلفون مشاركون: SLE Study Group from the RELESSAR Registry
المصدر: Lupus [Lupus] 2023 Nov; Vol. 32 (13), pp. 1555-1560. Date of Electronic Publication: 2023 Nov 08.
نوع المنشور: Multicenter Study; Journal Article
اللغة: English
بيانات الدورية: Publisher: SAGE Publications Country of Publication: England NLM ID: 9204265 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1477-0962 (Electronic) Linking ISSN: 09612033 NLM ISO Abbreviation: Lupus Subsets: MEDLINE
أسماء مطبوعة: Publication: London : SAGE Publications
Original Publication: Houndmills, Basingstoke, Hampshire, UK : Scientific & Medical Division, Macmillan Press Ltd., c1991-
مواضيع طبية MeSH: Lupus Erythematosus, Systemic*/diagnosis , Lupus Erythematosus, Systemic*/drug therapy , Lupus Erythematosus, Systemic*/epidemiology , Nephritis*, Humans ; Prednisone/therapeutic use ; Argentina/epidemiology ; Cross-Sectional Studies ; Immunosuppressive Agents/therapeutic use ; Severity of Illness Index
مستخلص: Objective: To evaluate the association between patients' characteristics and disease activity in an Argentine lupus registry.
Methods: Cross-sectional study. Disease activity was stratified into: Remission off-treatment: SLEDAI = 0, without prednisone and immunosuppressive drugs. Low disease activity Toronto Cohort (LDA-TC): SLEDAI ≤2, without prednisone or immunosuppressive drugs. Modified lupus low disease activity (mLLDAS): SLEDAI score of ≤4, with no activity in major organ systems and no new features, prednisone of ≤10 mg/day and/or immunosuppressive drugs (maintenance dose) and Active disease: SLEDAI score of >4 and prednisone >10 mg/day and immunosuppressive drugs. A descriptive analysis and logistic regression model were performed.
Results: A total of 1346 patients were included. Of them, 1.6% achieved remission off steroids, 0.8% LDA-TC, 12.1% mLLDAS and the remaining 85.4% had active disease. Active disease was associated with younger age ( p ≤ 0.001), a shorter time to diagnosis ( p ≤ 0.001), higher frequency of hospitalizations ( p ≤ 0.001), seizures ( p = 0.022), serosal disease ( p ≤ 0.001), nephritis ( p ≤ 0.001), higher SDI ( p ≤ 0.001), greater use of immunosuppressive therapies and higher doses of prednisone compared to those on mLLDAS. In the multivariable analysis, the variables associated with active disease were the presence of pleuritis (OR 2.1, 95% CI 1.2-3.9; p = 0.007), persistent proteinuria (OR 2.5, 95% CI 1.2-5.5; p ≤ 0.011), nephritis (OR 2.5, 95% CI 1.2-5.6; p = .018) and hospitalizations (OR 8.9, 95% CI 5.3-16.0; p ≤ 0.001) whereas age at entry into the registry was negatively associated with it (OR 0.9, 95% CI 0.9-1.0; p = 0.029).
Conclusion: Active disease was associated with shorter time to diagnosis, worse outcomes (SDI and hospitalizations) and renal, neurological and serosal disease.
Competing Interests: Declaration of conflicting interestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
فهرسة مساهمة: Keywords: Systemic lupus erythematosus; disease activity; outcomes
المشرفين على المادة: VB0R961HZT (Prednisone)
0 (Immunosuppressive Agents)
تواريخ الأحداث: Date Created: 20231108 Date Completed: 20231124 Latest Revision: 20231124
رمز التحديث: 20240628
DOI: 10.1177/09612033231209601
PMID: 37936393
قاعدة البيانات: MEDLINE
الوصف
تدمد:1477-0962
DOI:10.1177/09612033231209601