دورية أكاديمية
أعرض في EDS

A thalamocortical substrate for integrated information via critical synchronous bursting.

التفاصيل البيبلوغرافية
العنوان: A thalamocortical substrate for integrated information via critical synchronous bursting.
المؤلفون: Munn BR; Brain and Mind Centre, School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney 2050, Australia.; Complex Systems, School of Physics, Faculty of Science, University of Sydney, Sydney 2050, Australia., Müller EJ; Brain and Mind Centre, School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney 2050, Australia.; Complex Systems, School of Physics, Faculty of Science, University of Sydney, Sydney 2050, Australia., Aru J; Institute of Computer Science, University of Tartu, Tartu 51009, Estonia., Whyte CJ; Brain and Mind Centre, School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney 2050, Australia.; Complex Systems, School of Physics, Faculty of Science, University of Sydney, Sydney 2050, Australia., Gidon A; Institute of Biology, Humboldt University of Berlin, Berlin 10099, Germany.; NeuroCure Center of Excellence, Charité Universitätsmedizin Berlin, Berlin 10099, Germany., Larkum ME; Institute of Biology, Humboldt University of Berlin, Berlin 10099, Germany.; NeuroCure Center of Excellence, Charité Universitätsmedizin Berlin, Berlin 10099, Germany., Shine JM; Brain and Mind Centre, School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney 2050, Australia.; Complex Systems, School of Physics, Faculty of Science, University of Sydney, Sydney 2050, Australia.
المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2023 Nov 14; Vol. 120 (46), pp. e2308670120. Date of Electronic Publication: 2023 Nov 08.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Washington, DC : National Academy of Sciences
مواضيع طبية MeSH: Neurons*/physiology , Pyramidal Cells*/physiology, Animals ; Dendrites/physiology ; Thalamus/physiology ; Mammals
مستخلص: Understanding the neurobiological mechanisms underlying consciousness remains a significant challenge. Recent evidence suggests that the coupling between distal-apical and basal-somatic dendrites in thick-tufted layer 5 pyramidal neurons (L5 PN ), regulated by the nonspecific-projecting thalamus, is crucial for consciousness. Yet, it is uncertain whether this thalamocortical mechanism can support emergent signatures of consciousness, such as integrated information. To address this question, we constructed a biophysical network of dual-compartment thick-tufted L5 PN , with dendrosomatic coupling controlled by thalamic inputs. Our findings demonstrate that integrated information is maximized when nonspecific thalamic inputs drive the system into a regime of time-varying synchronous bursting. Here, the system exhibits variable spiking dynamics with broad pairwise correlations, supporting the enhanced integrated information. Further, the observed peak in integrated information aligns with criticality signatures and empirically observed layer 5 pyramidal bursting rates. These results suggest that the thalamocortical core of the mammalian brain may be evolutionarily configured to optimize effective information processing, providing a potential neuronal mechanism that integrates microscale theories with macroscale signatures of consciousness.
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فهرسة مساهمة: Keywords: biophysical network; dendrites; integrated information; nonspecific thalamus; synchronous bursting
تواريخ الأحداث: Date Created: 20231108 Date Completed: 20231110 Latest Revision: 20240509
رمز التحديث: 20240509
مُعرف محوري في PubMed: PMC10655573
DOI: 10.1073/pnas.2308670120
PMID: 37939085
قاعدة البيانات: MEDLINE
الوصف
تدمد:1091-6490
DOI:10.1073/pnas.2308670120