دورية أكاديمية
Genome-wide association and functional genomic analyses for various hoof health traits in North American Holstein cattle.
| العنوان: | Genome-wide association and functional genomic analyses for various hoof health traits in North American Holstein cattle. |
|---|---|
| المؤلفون: | Sousa LPB Junior; Department of Animal Sciences, Federal University of Bahia, Salvador, BA, 40170-110, Brazil., Pinto LFB; Department of Animal Sciences, Federal University of Bahia, Salvador, BA, 40170-110, Brazil., Cruz VAR; Department of Animal Sciences, Federal University of Bahia, Salvador, BA, 40170-110, Brazil., Oliveira GA Jr; Centre for Genetic Improvement of Livestock, Department of Animal Biosciences, University of Guelph, Guelph, ON, N1G 2W1, Canada., Rojas de Oliveira H; Centre for Genetic Improvement of Livestock, Department of Animal Biosciences, University of Guelph, Guelph, ON, N1G 2W1, Canada; Department of Animal Sciences, Purdue University, West Lafayette, IN 47907., Chud TS; Centre for Genetic Improvement of Livestock, Department of Animal Biosciences, University of Guelph, Guelph, ON, N1G 2W1, Canada; PEAK, Madison, WI 53718., Pedrosa VB; Department of Animal Sciences, Purdue University, West Lafayette, IN 47907., Miglior F; Centre for Genetic Improvement of Livestock, Department of Animal Biosciences, University of Guelph, Guelph, ON, N1G 2W1, Canada; Lactanet Canada, Guelph, ON, N1K 1E5, Canada., Schenkel FS; Centre for Genetic Improvement of Livestock, Department of Animal Biosciences, University of Guelph, Guelph, ON, N1G 2W1, Canada., Brito LF; Centre for Genetic Improvement of Livestock, Department of Animal Biosciences, University of Guelph, Guelph, ON, N1G 2W1, Canada; Department of Animal Sciences, Purdue University, West Lafayette, IN 47907. Electronic address: britol@purdue.edu. |
| المصدر: | Journal of dairy science [J Dairy Sci] 2024 Apr; Vol. 107 (4), pp. 2207-2230. Date of Electronic Publication: 2023 Nov 07. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Dairy Science Association Country of Publication: United States NLM ID: 2985126R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-3198 (Electronic) Linking ISSN: 00220302 NLM ISO Abbreviation: J Dairy Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Champaign, IL : American Dairy Science Association Original Publication: Lancaster, Pa. [etc.] |
| مواضيع طبية MeSH: | Foot Diseases*/genetics , Foot Diseases*/veterinary , Hoof and Claw* , Digital Dermatitis*/genetics , Cattle Diseases*/genetics , Foot Ulcer*/veterinary , Dermatitis*/veterinary , Skin Ulcer*, Cattle/genetics ; Animals ; Genome-Wide Association Study/veterinary ; Ulcer/veterinary ; Hyperplasia/veterinary ; Phenotype ; Genomics ; Hemorrhage/veterinary ; North America |
| مستخلص: | Hoof diseases are a major welfare and economic issue in the global dairy cattle production industry, which can be minimized through improved management and breeding practices. Optimal genetic improvement of hoof health could benefit from a deep understanding of the genetic background and biological underpinning of indicators of hoof health. Therefore, the primary objectives of this study were to perform genome-wide association studies, using imputed high-density genetic markers data from North American Holstein cattle, for 8 hoof-related traits: digital dermatitis, sole ulcer, sole hemorrhage, white line lesion, heel horn erosion, interdigital dermatitis, interdigital hyperplasia, and toe ulcer, and a hoof health index. De-regressed estimated breeding values from 25,580 Holstein animals were used as pseudo-phenotypes for the association analyses. The genomic quality control, genotype phasing, and genotype imputation were performed using the PLINK (version 1.9), Eagle (version 2.4.1), and Minimac4 software, respectively. The functional genomic analyses were performed using the GALLO R package and the DAVID platform. We identified 22, 34, 14, 22, 28, 33, 24, 43, and 15 significant markers for digital dermatitis, heel horn erosion, interdigital dermatitis, interdigital hyperplasia, sole hemorrhage, sole ulcer, toe ulcer, white line lesion disease, and the hoof health index, respectively. The significant markers were located across all autosomes, except BTA10, BTA12, BTA20, BTA26, BTA27, and BTA28. Moreover, the genomic regions identified overlap with various previously reported quantitative trait loci for exterior, health, meat and carcass, milk, production, and reproduction traits. The enrichment analyses identified 44 significant gene ontology terms. These enriched genomic regions harbor various candidate genes previously associated with bone development, metabolism, and infectious and immunological diseases. These findings indicate that hoof health traits are highly polygenic and influenced by a wide range of biological processes. (The Authors. Published by Elsevier Inc. on behalf of the American Dairy Science Association®. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).) |
| فهرسة مساهمة: | Keywords: dairy cattle; digital dermatitis; disease resistance; hoof disease |
| SCR Disease Name: | digital ulcers |
| تواريخ الأحداث: | Date Created: 20231108 Date Completed: 20240325 Latest Revision: 20240325 |
| رمز التحديث: | 20240325 |
| DOI: | 10.3168/jds.2023-23806 |
| PMID: | 37939841 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1525-3198 |
|---|---|
| DOI: | 10.3168/jds.2023-23806 |