دورية أكاديمية
Alpha-lipoic acid suppresses gibberellic acid nephrotoxicity in Nile tilapia (Oreochromis niloticus) via modulating oxidative stress, inflammation, cytokine production, and apoptosis.
| العنوان: | Alpha-lipoic acid suppresses gibberellic acid nephrotoxicity in Nile tilapia (Oreochromis niloticus) via modulating oxidative stress, inflammation, cytokine production, and apoptosis. |
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| المؤلفون: | El-Houseiny W; Department of Aquatic Animal Medicine, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt. Electronic address: drwalaaelhouseiny@yahoo.com., Arisha AH; Department of Animal Physiology and Biochemistry, Faculty of Veterinary Medicine, Badr University in Cairo (BUC), Badr City, Cairo, Egypt; Department of Physiology, Faculty of Veterinary Medicine, Zagazig University, Zagazig 44511, Egypt., Metwally MMM; Department of Pathology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, 44511, Egypt., Abdel-Warith AA; Department of Zoology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia., Younis EM; Department of Zoology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia., Davies SJ; Aquaculture Nutrition Research Unit ANRU, Carna Research Station, Ryan Institute, College of Science and Engineering, University of Galway, H91V8Y1 Galway, Ireland., Hassan BA; Pharmacology Department, Faculty of Pharmacy, Future University, Cairo 11835, Egypt., Abd-Elhakim YM; Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Zagazig University, 4511, Egypt. Electronic address: yasmina_forensic@hotmail.com. |
| المصدر: | Pesticide biochemistry and physiology [Pestic Biochem Physiol] 2023 Nov; Vol. 196, pp. 105598. Date of Electronic Publication: 2023 Aug 29. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Academic Press Country of Publication: United States NLM ID: 1301573 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9939 (Electronic) Linking ISSN: 00483575 NLM ISO Abbreviation: Pestic Biochem Physiol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: New York Ny : Academic Press |
| مواضيع طبية MeSH: | Thioctic Acid*/pharmacology , Cichlids*, Animals ; Inflammation ; Oxidative Stress ; Antioxidants/pharmacology ; Apoptosis ; Gene Expression |
| مستخلص: | Globally, gibberellic acid (GA) is one of the extensively used plant growth regulators in agriculture. Yet, there is limited information about their toxicity to fish. Recently, alpha lipoic acid (ALA) has drawn much interest due to its antioxidant properties. This study was planned to determine whether ALA might protect Nile tilapia's kidneys from the toxic effects of GA and the probable underlying mechanisms. Thus, 240 Oreochromis niloticus fish (average initial weight 30.67 ± 0.57) were allocated into four groups received a basal diet or a basal diet supplemented with 600 mg/kg ALA or a basal diet but exposed to a GA (150 mg/L), or ALA-fortified diet and concurrently exposed to GA as previously described. After 60 days, hematological, oxidative stress, lipid peroxidation, stress indices, selected kidney toxic byproducts, histological investigations, and associated gene expression were assessed. Anemia, leukopenia, hypoproteinemia, and elevated kidney function indicators were noticed in the GA-treated group. Additionally, there were detectable cortisol, glucose, 8-OHdG, and MDA increases. However, there was a considerable drop in Cat, Sod, Gpx, GSH, and AChE levels. Structural damage to the kidneys was also identified. In the kidney of fish treated with GA, pro-inflammatory cytokines (tnfα, il-1β), stress, and apoptotic genes (hsp70, pcna, caspase-3, and p53) genes were markedly up-regulated, while anti-oxidative (cat, sod) gene expression was downregulated. Conversely, adding ALA to the diet abolished the GA-induced changes in most of the markers mentioned above. Conclusively, ALA protects against GA-induced hematotoxicity, oxidative damage, and nephrotoxic effects in Nile tilapia fish. Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2023 Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Alpha lipoic acid; Gibberellic acid; Hematology; Oxidative stress; Pro-inflammatory cytokines; mRNA transcription |
| المشرفين على المادة: | 73Y7P0K73Y (Thioctic Acid) BU0A7MWB6L (gibberellic acid) 0 (Antioxidants) |
| تواريخ الأحداث: | Date Created: 20231109 Date Completed: 20231113 Latest Revision: 20231129 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.pestbp.2023.105598 |
| PMID: | 37945227 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1095-9939 |
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| DOI: | 10.1016/j.pestbp.2023.105598 |