دورية أكاديمية

Integrating Therapeutic Ultrasound With Nanosized Drug Delivery Systems in the Battle Against Cancer.

التفاصيل البيبلوغرافية
العنوان: Integrating Therapeutic Ultrasound With Nanosized Drug Delivery Systems in the Battle Against Cancer.
المؤلفون: Moradi Kashkooli; Department of Physics, Toronto Metropolitan University, Toronto, ON, Canada., Jakhmola A; Department of Physics, Toronto Metropolitan University, Toronto, ON, Canada., Ferrier GA; Department of Physics, Toronto Metropolitan University, Toronto, ON, Canada., Hornsby TK; Department of Physics, Toronto Metropolitan University, Toronto, ON, Canada., Tavakkoli JJ; Department of Physics, Toronto Metropolitan University, Toronto, ON, Canada.; Institute for Biomedical Engineering, Science and Technology (iBEST), Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, ON, Canada., Kolios MC; Department of Physics, Toronto Metropolitan University, Toronto, ON, Canada.; Institute for Biomedical Engineering, Science and Technology (iBEST), Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, ON, Canada.
المصدر: Technology in cancer research & treatment [Technol Cancer Res Treat] 2023 Jan-Dec; Vol. 22, pp. 15330338231211472.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: SAGE Country of Publication: United States NLM ID: 101140941 Publication Model: Print Cited Medium: Internet ISSN: 1533-0338 (Electronic) Linking ISSN: 15330338 NLM ISO Abbreviation: Technol Cancer Res Treat Subsets: MEDLINE
أسماء مطبوعة: Publication: 2015-: Thousand Oaks, CA : SAGE
Original Publication: Schenectady, NY : Adenine Press, c2002-
مواضيع طبية MeSH: Antineoplastic Agents*/therapeutic use , Neoplasms*/drug therapy , Neoplasms*/pathology , Nanoparticles* , Ultrasonic Therapy*, Humans ; Drug Delivery Systems/methods ; Drug Carriers ; Tumor Microenvironment
مستخلص: Controlled, localized, and timely activation of nanosized drug delivery systems (NSDDSs), using an external stimulus such as therapeutic ultrasound (TUS), can improve the efficacy of cancer treatments compared to either conventional chemotherapy methods or passive NSDDSs alone. Specifically, TUS induces thermal and mechanical effects that trigger drug release from NSDDSs and overcomes drug delivery barriers in tumor microenvironments to allow nanoparticle drug carriers to penetrate more deeply into tumor tissue while minimizing side effects. This review highlights recent advancements, contemplates future prospects, and addresses challenges in using TUS-mediated NSDDSs for cancer treatment, encompassing preclinical and clinical applications.
Competing Interests: Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
التعليقات: Erratum in: Technol Cancer Res Treat. 2024 Jan-Dec;23:15330338231223384. (PMID: 38343160)
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فهرسة مساهمة: Keywords: cancer treatment; drug release kinetics from nanoparticles; nanomedicine; nanosized drug delivery systems; solid tumors; therapeutic ultrasound; thermal and nonthermal effects induced by ultrasound; ultrasound-activated drug delivery
المشرفين على المادة: 0 (Antineoplastic Agents)
0 (Drug Carriers)
تواريخ الأحداث: Date Created: 20231110 Date Completed: 20231113 Latest Revision: 20240212
رمز التحديث: 20240212
مُعرف محوري في PubMed: PMC10637173
DOI: 10.1177/15330338231211472
PMID: 37946517
قاعدة البيانات: MEDLINE
الوصف
تدمد:1533-0338
DOI:10.1177/15330338231211472