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Comparing different strategies to reduce hepatocellular damage in obese common marmosets (Callithrix jacchus).

التفاصيل البيبلوغرافية
العنوان: Comparing different strategies to reduce hepatocellular damage in obese common marmosets (Callithrix jacchus).
المؤلفون: Brown MG; Research Animal Resources, Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Feller LE; Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Trupkiewicz JG; Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Hutchinson EK; Research Animal Resources, Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Izzi JM; Research Animal Resources, Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
المصدر: Journal of medical primatology [J Med Primatol] 2024 Feb; Vol. 53 (1), pp. e12683. Date of Electronic Publication: 2023 Nov 09.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Wiley Country of Publication: Denmark NLM ID: 0320626 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1600-0684 (Electronic) Linking ISSN: 00472565 NLM ISO Abbreviation: J Med Primatol Subsets: MEDLINE
أسماء مطبوعة: Publication: Copenhagen : Wiley
Original Publication: Basel, New York, Karger.
مواضيع طبية MeSH: Carcinoma, Hepatocellular* , Liver Neoplasms*, Animals ; Callithrix ; Obesity/complications ; Body Weight
مستخلص: Background: Obesity in common marmosets (Callithrix jacchus) can lead to various liver pathologies. In other species, reduced caloric intake and weight loss improve prognosis, and, often, hepatoprotectants are used to halt or reverse hepatocellular damage from fat deposition in the liver. There are no published therapies for reducing hepatocellular damage in obese marmosets.
Methods: Fifteen obese marmosets were used to evaluate the ability of caloric restriction and pharmacologic therapy (S-adenosylmethionine + milk thistle extract, or SMT), alone and combined, to reduce elevated liver enzymes. Body weight and serum chemistries were measured every 4 weeks for 6 months.
Results: Across treatment groups, there was a significant reduction in liver enzymes ALT and AST over time. SMT alone significantly reduced liver enzymes ALT and AST at 6 months from baseline.
Conclusions: Caloric restriction and SMT, alone and combined, are effective at reducing liver enzyme levels in obese marmosets.
(© 2023 The Authors. Journal of Medical Primatology published by John Wiley & Sons Ltd.)
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فهرسة مساهمة: Keywords: S-adenosylmethionine; SAMe; fatty liver disease; glycogen hepatopathy; milk thistle; silybin
تواريخ الأحداث: Date Created: 20231110 Date Completed: 20240214 Latest Revision: 20240327
رمز التحديث: 20240327
DOI: 10.1111/jmp.12683
PMID: 37946549
قاعدة البيانات: MEDLINE
الوصف
تدمد:1600-0684
DOI:10.1111/jmp.12683