دورية أكاديمية
Discovery of the covalent SARS-CoV-2 M pro inhibitors from antiviral herbs via integrating target-based high-throughput screening and chemoproteomic approaches.
| العنوان: | Discovery of the covalent SARS-CoV-2 M pro inhibitors from antiviral herbs via integrating target-based high-throughput screening and chemoproteomic approaches. |
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| المؤلفون: | Zhang YN; Shanghai Frontiers Science Center of TCM Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China., Zhu GH; Shanghai Frontiers Science Center of TCM Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China., Liu W; Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China., Chen XX; Shanghai Frontiers Science Center of TCM Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China., Xie YY; Academy of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China., Xu JR; Academy of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China., Jiang MF; Shanghai Frontiers Science Center of TCM Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China., Zhuang XY; Shanghai Frontiers Science Center of TCM Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China., Zhang WD; Shanghai Frontiers Science Center of TCM Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China., Chen HZ; Shanghai Frontiers Science Center of TCM Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China.; Academy of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China., Ge GB; Shanghai Frontiers Science Center of TCM Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China. |
| المصدر: | Journal of medical virology [J Med Virol] 2023 Nov; Vol. 95 (11), pp. e29208. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-Liss Country of Publication: United States NLM ID: 7705876 Publication Model: Print Cited Medium: Internet ISSN: 1096-9071 (Electronic) Linking ISSN: 01466615 NLM ISO Abbreviation: J Med Virol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: New York Ny : Wiley-Liss Original Publication: New York, Liss. |
| مواضيع طبية MeSH: | COVID-19* , Plants, Medicinal*, Humans ; SARS-CoV-2 ; High-Throughput Screening Assays ; Quercetin/pharmacology ; Protease Inhibitors/pharmacology ; Protease Inhibitors/chemistry ; Plant Extracts/pharmacology ; Antiviral Agents/pharmacology ; Antiviral Agents/chemistry ; Gallic Acid/pharmacology ; Molecular Docking Simulation |
| مستخلص: | The main proteases (M pro ) are highly conserved cysteine-rich proteins that can be covalently modified by numerous natural and synthetic compounds. Herein, we constructed an integrative approach to efficiently discover covalent inhibitors of M pro from complex herbal matrices. This work begins with biological screening of 60 clinically used antiviral herbal medicines, among which Lonicera japonica Flos (LJF) demonstrated the strongest anti-M pro effect (IC (© 2023 Wiley Periodicals LLC.) |
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| فهرسة مساهمة: | Keywords: Lonicera japonica Flos (LJF); SARS-CoV-2 Mpro; antiviral agents; covalent inhibitors; inhibitory mechanism |
| المشرفين على المادة: | 9IKM0I5T1E (Quercetin) 0 (Protease Inhibitors) 0 (Plant Extracts) 0 (Antiviral Agents) 632XD903SP (Gallic Acid) |
| تواريخ الأحداث: | Date Created: 20231110 Date Completed: 20231113 Latest Revision: 20231129 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1002/jmv.29208 |
| PMID: | 37947293 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1096-9071 |
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| DOI: | 10.1002/jmv.29208 |