دورية أكاديمية
أعرض في EDS

Malaria surveillance reveals parasite relatedness, signatures of selection, and correlates of transmission across Senegal.

التفاصيل البيبلوغرافية
العنوان: Malaria surveillance reveals parasite relatedness, signatures of selection, and correlates of transmission across Senegal.
المؤلفون: Schaffner SF; Infectious Disease and Microbiome Program, The Broad Institute, Cambridge, MA, USA., Badiane A; Centre International de recherche, de Formation en Genomique Appliquee et de Surveillance Sanitaire (CIGASS), Dakar, Senegal., Khorgade A; Infectious Disease and Microbiome Program, The Broad Institute, Cambridge, MA, USA., Ndiop M; Programme National de Lutte Contre le Paludisme (PNLP), Dakar, Senegal., Gomis J; Centre International de recherche, de Formation en Genomique Appliquee et de Surveillance Sanitaire (CIGASS), Dakar, Senegal., Wong W; Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, MA, USA., Ndiaye YD; Centre International de recherche, de Formation en Genomique Appliquee et de Surveillance Sanitaire (CIGASS), Dakar, Senegal., Diedhiou Y; Centre International de recherche, de Formation en Genomique Appliquee et de Surveillance Sanitaire (CIGASS), Dakar, Senegal., Thwing J; Centers for Disease Control and Prevention, Atlanta, GA, USA., Seck MC; Centre International de recherche, de Formation en Genomique Appliquee et de Surveillance Sanitaire (CIGASS), Dakar, Senegal., Early A; Infectious Disease and Microbiome Program, The Broad Institute, Cambridge, MA, USA., Sy M; Centre International de recherche, de Formation en Genomique Appliquee et de Surveillance Sanitaire (CIGASS), Dakar, Senegal., Deme A; Centre International de recherche, de Formation en Genomique Appliquee et de Surveillance Sanitaire (CIGASS), Dakar, Senegal., Diallo MA; Centre International de recherche, de Formation en Genomique Appliquee et de Surveillance Sanitaire (CIGASS), Dakar, Senegal., Sy N; Section de Lutte Anti-Parasitaire (SLAP) Clinic, Thies, Senegal., Sene A; Centre International de recherche, de Formation en Genomique Appliquee et de Surveillance Sanitaire (CIGASS), Dakar, Senegal., Ndiaye T; Centre International de recherche, de Formation en Genomique Appliquee et de Surveillance Sanitaire (CIGASS), Dakar, Senegal., Sow D; Centre International de recherche, de Formation en Genomique Appliquee et de Surveillance Sanitaire (CIGASS), Dakar, Senegal., Dieye B; Centre International de recherche, de Formation en Genomique Appliquee et de Surveillance Sanitaire (CIGASS), Dakar, Senegal., Ndiaye IM; Centre International de recherche, de Formation en Genomique Appliquee et de Surveillance Sanitaire (CIGASS), Dakar, Senegal., Gaye A; Centre International de recherche, de Formation en Genomique Appliquee et de Surveillance Sanitaire (CIGASS), Dakar, Senegal., Ndiaye A; Centre International de recherche, de Formation en Genomique Appliquee et de Surveillance Sanitaire (CIGASS), Dakar, Senegal., Battle KE; Institute for Disease Modeling in Global Health, Bill and Melinda Gates Foundation, Seattle, WA, USA., Proctor JL; Institute for Disease Modeling in Global Health, Bill and Melinda Gates Foundation, Seattle, WA, USA., Bever C; Institute for Disease Modeling in Global Health, Bill and Melinda Gates Foundation, Seattle, WA, USA., Fall FB; Programme National de Lutte Contre le Paludisme (PNLP), Dakar, Senegal., Diallo I; Programme National de Lutte Contre le Paludisme (PNLP), Dakar, Senegal., Gaye S; Programme National de Lutte Contre le Paludisme (PNLP), Dakar, Senegal., Sene D; Programme National de Lutte Contre le Paludisme (PNLP), Dakar, Senegal., Hartl DL; Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA, USA., Wirth DF; Infectious Disease and Microbiome Program, The Broad Institute, Cambridge, MA, USA.; Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, MA, USA., MacInnis B; Infectious Disease and Microbiome Program, The Broad Institute, Cambridge, MA, USA., Ndiaye D; Centre International de recherche, de Formation en Genomique Appliquee et de Surveillance Sanitaire (CIGASS), Dakar, Senegal., Volkman SK; Infectious Disease and Microbiome Program, The Broad Institute, Cambridge, MA, USA. svolkman@hsph.harvard.edu.; Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, MA, USA. svolkman@hsph.harvard.edu.; College of Natural, Behavioral, and Health Sciences, Simmons University, Boston, MA, USA. svolkman@hsph.harvard.edu.
المصدر: Nature communications [Nat Commun] 2023 Nov 10; Vol. 14 (1), pp. 7268. Date of Electronic Publication: 2023 Nov 10.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [London] : Nature Pub. Group
مواضيع طبية MeSH: Parasites* , Malaria, Falciparum*/epidemiology , Malaria, Falciparum*/parasitology , Malaria*/epidemiology, Animals ; Humans ; Senegal/epidemiology ; Plasmodium falciparum/genetics
مستخلص: We here analyze data from the first year of an ongoing nationwide program of genetic surveillance of Plasmodium falciparum parasites in Senegal. The analysis is based on 1097 samples collected at health facilities during passive malaria case detection in 2019; it provides a baseline for analyzing parasite genetic metrics as they vary over time and geographic space. The study's goal was to identify genetic metrics that were informative about transmission intensity and other aspects of transmission dynamics, focusing on measures of genetic relatedness between parasites. We found the best genetic proxy for local malaria incidence to be the proportion of polygenomic infections (those with multiple genetically distinct parasites), although this relationship broke down at low incidence. The proportion of related parasites was less correlated with incidence while local genetic diversity was uninformative. The type of relatedness could discriminate local transmission patterns: two nearby areas had similarly high fractions of relatives, but one was dominated by clones and the other by outcrossed relatives. Throughout Senegal, 58% of related parasites belonged to a single network of relatives, within which parasites were enriched for shared haplotypes at known and suspected drug resistance loci and at one novel locus, reflective of ongoing selection pressure.
(© 2023. The Author(s).)
التعليقات: Update of: medRxiv. 2023 May 30;:. (PMID: 37131838)
References: Genome Res. 2016 Sep;26(9):1288-99. (PMID: 27531718)
Malar J. 2020 Jul 13;19(1):244. (PMID: 32660491)
Genome Med. 2017 Jan 24;9(1):5. (PMID: 28118860)
Bioinformatics. 2018 Jan 1;34(1):9-15. (PMID: 28961721)
Malar J. 2014 Mar 12;13:89. (PMID: 24618119)
PLoS Genet. 2021 Dec 20;17(12):e1009335. (PMID: 34928954)
Sci Rep. 2018 Feb 6;8(1):2464. (PMID: 29410428)
N Engl J Med. 2001 Jan 25;344(4):257-63. (PMID: 11172152)
PLoS Genet. 2017 Oct 27;13(10):e1007065. (PMID: 29077712)
Am J Trop Med Hyg. 2020 Apr;102(4):811-820. (PMID: 31833469)
Ann N Y Acad Sci. 2015 Apr;1342:10-8. (PMID: 25694157)
Mol Ecol. 2021 Jan;30(1):100-113. (PMID: 33107096)
Malar J. 2020 Aug 3;19(1):276. (PMID: 32746830)
PLoS Comput Biol. 2021 Aug 19;17(8):e1009287. (PMID: 34411093)
Malar J. 2018 May 15;17(1):196. (PMID: 29764422)
Nat Rev Genet. 2021 Aug;22(8):502-517. (PMID: 33833443)
Malar J. 2016 Dec 20;15(1):597. (PMID: 27998271)
PNAS Nexus. 2022 Sep 10;1(4):pgac187. (PMID: 36246152)
Nat Microbiol. 2023 Jul;8(7):1213-1226. (PMID: 37169919)
Malar J. 2019 May 7;18(1):163. (PMID: 31064369)
Elife. 2021 Aug 10;10:. (PMID: 34372970)
Genet Res. 1995 Feb;65(1):53-61. (PMID: 7750746)
Wellcome Open Res. 2021 Feb 24;6:42. (PMID: 33824913)
Malar J. 2020 Jul 27;19(1):271. (PMID: 32718342)
PLoS Genet. 2018 May 23;14(5):e1007279. (PMID: 29791438)
Mol Biol Evol. 2021 Jan 4;38(1):274-289. (PMID: 32898225)
Travel Med Infect Dis. 2020 Nov - Dec;38:101880. (PMID: 32949701)
Sci Rep. 2018 Oct 25;8(1):15763. (PMID: 30361631)
Proc Natl Acad Sci U S A. 2015 Jun 2;112(22):7067-72. (PMID: 25941365)
Annu Rev Microbiol. 2020 Sep 8;74:761-786. (PMID: 32905749)
Malar J. 2008 Oct 29;7:223. (PMID: 18959790)
Int J Parasitol Drugs Drug Resist. 2021 Dec;17:12-22. (PMID: 34333350)
Sci Rep. 2022 Jan 18;12(1):938. (PMID: 35042879)
معلومات مُعتمدة: R21 AI141843 United States AI NIAID NIH HHS
تواريخ الأحداث: Date Created: 20231110 Date Completed: 20231113 Latest Revision: 20240210
رمز التحديث: 20240210
مُعرف محوري في PubMed: PMC10638404
DOI: 10.1038/s41467-023-43087-4
PMID: 37949851
قاعدة البيانات: MEDLINE
الوصف
تدمد:2041-1723
DOI:10.1038/s41467-023-43087-4