دورية أكاديمية
Trigeminal or peripheral nerve stimulation improves functional outcomes of nerve recovery in a rodent forelimb gap repair model.
| العنوان: | Trigeminal or peripheral nerve stimulation improves functional outcomes of nerve recovery in a rodent forelimb gap repair model. |
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| المؤلفون: | Nicksic PJ; University of Wisconsin, Division of Plastic and Reconstructive Surgery, Madison, WI, United States., Donnelly DT; University of Wisconsin, Division of Plastic and Reconstructive Surgery, Madison, WI, United States., Zeng W; University of Wisconsin, Division of Plastic and Reconstructive Surgery, Madison, WI, United States., Seitz AJ; University of Wisconsin, Division of Plastic and Reconstructive Surgery, Madison, WI, United States., Poore SO; University of Wisconsin, Division of Plastic and Reconstructive Surgery, Madison, WI, United States., Suminski AJ; University of Wisconsin, Department of Neurological Surgery, Madison, WI, United States; Wisconsin Institute for Translational Neuroengineering, Madison, WI, United States., Dingle AM; University of Wisconsin, Division of Plastic and Reconstructive Surgery, Madison, WI, United States. Electronic address: dingle@surgery.wisc.edu. |
| المصدر: | Journal of plastic, reconstructive & aesthetic surgery : JPRAS [J Plast Reconstr Aesthet Surg] 2024 Jan; Vol. 88, pp. 57-65. Date of Electronic Publication: 2023 Oct 29. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101264239 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-0539 (Electronic) Linking ISSN: 17486815 NLM ISO Abbreviation: J Plast Reconstr Aesthet Surg Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam, The Netherlands : Elsevier, c2006- |
| مواضيع طبية MeSH: | Peripheral Nerve Injuries*/surgery , Rodentia*, Animals ; Rats ; Electric Stimulation/methods ; Forelimb ; Median Nerve ; Nerve Regeneration/physiology ; Rats, Inbred Lew ; Recovery of Function/physiology ; Trigeminal Nerve |
| مستخلص: | Background: The hypothesis of this study was that trigeminal nerve stimulation (TNS) or peripheral nerve stimulation (PNS) could improve functional outcomes of peripheral nerve injury in a rat forelimb model when compared to control rats not receiving electrical stimulation (ES). While PNS is known to improve outcomes after nerve surgery, the role of TNS has not been explored. Methods: Lewis rats were trained to perform a reach and grasp task before receiving a 2 mm gap repair of the ulnar and median nerves and randomized into four treatment groups: (1) sham injury, (2) nerve injury with sham ES, (3) nerve injury with PNS, and (4) nerve injury with TNS. Functional motor (median pull force and percent success in motor task) and sensory metrics (forelimb paw withdrawal thresholds) were collected both pre-injury and throughout rehabilitation. Nerves stained using Gomori's trichrome were assessed quantitatively and qualitatively. Results: The sham ES group did not recover their pre-injury baseline functional outcomes. In contrast, the TNS and PNS groups fully recovered following injury, with no difference in functional outcomes between the pre-injury baseline and the final week of rehabilitation (P > 0.05, all). Histomorphology results demonstrated no quantitative difference, but qualitative differences in architecture were evident. Conclusions: Electrical stimulation of the trigeminal nerve or the injured nerve improved the functional outcomes of nerve regeneration in rodents. Histomorphology results of nerves from the TNS group support the proposed central mechanisms. This is an important step in translating this therapy as an adjunct, non-invasive treatment for high, mixed nerve injuries in humans. Competing Interests: Declaration of Competing Interest None declared. (Copyright © 2023 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Electrical stimulation; Nerve injury; Nerve regeneration; Trigeminal nerve |
| تواريخ الأحداث: | Date Created: 20231112 Date Completed: 20240102 Latest Revision: 20240216 |
| رمز التحديث: | 20240216 |
| DOI: | 10.1016/j.bjps.2023.10.118 |
| PMID: | 37952438 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1878-0539 |
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| DOI: | 10.1016/j.bjps.2023.10.118 |