دورية أكاديمية
Multicomponent decellularized extracellular matrix of caprine small intestine submucosa based bioactive hydrogel promoting full-thickness burn wound healing in rabbits.
| العنوان: | Multicomponent decellularized extracellular matrix of caprine small intestine submucosa based bioactive hydrogel promoting full-thickness burn wound healing in rabbits. |
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| المؤلفون: | Singh H; Department of Polymer and Process Engineering, Indian Institute of Technology Roorkee, Roorkee, Uttarakhand, India; Biological Sciences and Engineering, Indian Institute of Technology Gandhinagar, Gujarat, India; Department of Biology, Khalifa University, Main Campus, Abu Dhabi, United Arab Emirates; Advanced Materials Chemistry Center, Khalifa University, SAN Campus, Abu Dhabi, United Arab Emirates., Hassan S; Department of Biology, Khalifa University, Main Campus, Abu Dhabi, United Arab Emirates; Advanced Materials Chemistry Center, Khalifa University, SAN Campus, Abu Dhabi, United Arab Emirates. Electronic address: shabir.hassan@ku.ac.ae., Nabi SU; Department of Veterinary Clinical Medicine, Faculty of Veterinary Sciences & Animal Husbandary Shuhama, Sher-e-Kashmir University of Agricultural Sciences and Technology of Kashmir, Jammu and Kashmir, India., Mishra NC; Department of Polymer and Process Engineering, Indian Institute of Technology Roorkee, Roorkee, Uttarakhand, India. Electronic address: narayan.mishra@pe.iitr.ac.in., Dhanka M; Biological Sciences and Engineering, Indian Institute of Technology Gandhinagar, Gujarat, India., Purohit SD; School of Chemical Engineering, Yeungnam University, Gyeongsan, South Korea., Ganai NA; Molecular Genetics Laboratory, Division of Animal Genetics and Breeding, Faculty of Veterinary Sciences and Animal Husbandry Shuhama, Sher-e-Kashmir University of Agricultural Sciences and Technology of Kashmir, Jammu and Kashmir, India., Bhaskar R; School of Chemical Engineering, Yeungnam University, Gyeongsan, South Korea., Han SS; School of Chemical Engineering, Yeungnam University, Gyeongsan, South Korea., Qurashi AUH; Advanced Materials Chemistry Center, Khalifa University, SAN Campus, Abu Dhabi, United Arab Emirates; Department of Chemistry, Khalifa University, SAN Campus, Abu Dhabi, United Arab Emirates., Bashir SM; Biochemistry and Molecular Biology Lab, Division of Veterinary Biochemistry, Faculty of Veterinary Sciences and Animal Husbandry Shuhama, Sher-e-Kashmir University of Agricultural Sciences and Technology of Kashmir, Jammu and Kashmir, India. Electronic address: showkeen@skuastkashmir.ac.in. |
| المصدر: | International journal of biological macromolecules [Int J Biol Macromol] 2024 Jan; Vol. 255, pp. 127810. Date of Electronic Publication: 2023 Nov 11. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Amsterdam : Elsevier Original Publication: Guildford, Eng., IPC Science and Technology Press. |
| مواضيع طبية MeSH: | Zinc Oxide*/pharmacology , Zinc Oxide*/therapeutic use , Burns*/drug therapy , Burns*/metabolism, Rabbits ; Animals ; Hydrogels/pharmacology ; Hydrogels/therapeutic use ; Decellularized Extracellular Matrix ; Antioxidants/pharmacology ; Antioxidants/therapeutic use ; Goats ; Wound Healing ; Intestine, Small/metabolism ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use |
| مستخلص: | Effective treatment for full-thickness burn wounds has remained challenging for clinicians. Among various strategies, extracellular gel-based dressing materials have gained attention to promote effective and rapid wound healing. These gel-based materials are porous and have antioxidant, antibacterial, hydrophilic, biodegradation, and biocompatible properties and hence can be used to alleviate burn wound healing. In concurrence with these findings, the present study evaluates thermo-responsive and self-assembled decellularized extracellular matrix (ECM) of caprine small intestine submucosa (DG-SIS) gel-based dressing material for burn wound healing. To expedite healing and efficiently tackle excessive free radicals and bioburden at the burn wound site, DG-SIS gel is fortified with antibacterial components (zinc oxide nanoparticles; ZnO) and a potent antioxidant agent (Vitamin-C;Vt-C). ZnO- and Vt-C-enriched DG-SIS (DG-SIS/ZnO/Vt-C) gels significantly increased the antioxidant and antibacterial activity of the therapeutic hydrogel. Additionally, the fabricated DG-SIS/ZnO/Vt-C bioactive gel resulted in significant full-thickness burn wound contraction (97.75 % in 14 days), a lower inflammatory effect, and enhanced angiogenesis with the highest collagen synthesis (1.22 μg/mg in 14 days) at the wound site. The outcomes from this study demonstrate a synergistic effect of ZnO/Vt-C in the bioactive gel as an effective and inexpensive therapeutic approach for full-thickness burn wound treatment. Competing Interests: Declaration of competing interest The authors declare no conflict of interest. (Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Bioactive gel; Burn wound healing; Decellularized extracellular matrix; Vitamin-C; Zinc oxide nanoparticles |
| المشرفين على المادة: | 0 (Hydrogels) 0 (Decellularized Extracellular Matrix) SOI2LOH54Z (Zinc Oxide) 0 (Antioxidants) 0 (Anti-Bacterial Agents) |
| تواريخ الأحداث: | Date Created: 20231112 Date Completed: 20240110 Latest Revision: 20240110 |
| رمز التحديث: | 20240110 |
| DOI: | 10.1016/j.ijbiomac.2023.127810 |
| PMID: | 37952796 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1879-0003 |
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| DOI: | 10.1016/j.ijbiomac.2023.127810 |